Cryotherapy versus radical prostatectomy as a salvage treatment for radio-recurrent prostate cancer.
Cryoablation
Prostate cancer
Radiation therapy
Radical prostatectomy
Salvage surgery
Journal
World journal of urology
ISSN: 1433-8726
Titre abrégé: World J Urol
Pays: Germany
ID NLM: 8307716
Informations de publication
Date de publication:
11 Sep 2024
11 Sep 2024
Historique:
received:
08
05
2024
accepted:
30
07
2024
medline:
11
9
2024
pubmed:
11
9
2024
entrez:
11
9
2024
Statut:
epublish
Résumé
The aim of this study is to compare outcomes of SRP (salvage radical prostatectomy) with SCAP (salvage cryoablation of the prostate) in local radio-recurrent PCa (prostate cancer) patients. A retrospective analysis of a multicentric European Society of Uro-technology (ESUT) database was performed. Data on patients with local recurrent PCa after radiotherapy who underwent salvage treatment were collected. Patients and their respective disease characteristics, perioperative complications as well as oncological outcomes were then described. The treatment success rate was defined as PSA nadir < 0,4 ng/ml. Any complications were graded according to the modified Clavien system. A descriptive and comparative analysis was performed using SPSS software. 25 patients underwent SRP and 71 patients received SCAP. The mean follow-up was 24 months. The median PSA level before initial treatment was 8.3 (range 7-127) ng/ml. The success rates of SRP and SCAP were largely comparable (88% (22 patients) vs. 67.7% (48 patients), respectively, p = 0.216). The mean serum PSA levels at 12 months after salvage treatment were 1.2 ± 0.2 ng/mL vs. 0.25 ± 0.5 ng/mL, p > 0.05). During the follow-up period, only 3 (12%) patients in the SRP group had PSA recurrence compared with 21 patients (29.6%) in the SCAP group. The 5-year BRFS was similar (51,6% and 48,2%, p = 0,08) for SRP and SCAP respectively. The 5-year overall survival rate was 91.7%, and 89,7% (p = 0.669) and the 5-year cancer-specific survival was 91.7%, and 97,1% (p = 0.077), after SRP and SCAP respectively. No difference was found regarding the complications. Both SRP and SCAP should be considered as valid treatment options for patients with local recurrence of PCa after radiotherapy. SCAP has a potentially lower risk of morbidity and acceptable intermediate-term oncological efficacy, but a longer follow up and a higher number of patients is ideally needed to draw any long-term conclusions regarding the oncological data.
Identifiants
pubmed: 39259304
doi: 10.1007/s00345-024-05199-4
pii: 10.1007/s00345-024-05199-4
doi:
Substances chimiques
Prostate-Specific Antigen
EC 3.4.21.77
Types de publication
Journal Article
Comparative Study
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
515Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M et al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:E359–E386. https://doi.org/10.1002/ijc.29210
doi: 10.1002/ijc.29210
pubmed: 25220842
Valle LF, Lehrer EJ, Markovic D, Elashoff D, Levin-Epstein R, Karnes RJ et al (2021) A systematic review and Meta-analysis of local salvage therapies after radiotherapy for prostate Cancer (MASTER)[Formula presented]. Eur Urol 80:280–292. https://doi.org/10.1016/j.eururo.2020.11.010
doi: 10.1016/j.eururo.2020.11.010
pubmed: 33309278
Scherzer ND, DiBiase ZS, Srivastav SK, Thomas R, DiBiase SJ (2019) Regional differences in the treatment of localized prostate Cancer: an analysis of surgery and Radiation utilization in the United States. Adv Radiat Oncol 4:331–336. https://doi.org/10.1016/j.adro.2019.01.004
doi: 10.1016/j.adro.2019.01.004
pubmed: 31011678
pmcid: 6460229
Chen BT, Wood DP (2003) Salvage prostatectomy in patients who have failed radiation therapy or cryotherapy as primary treatment for prostate cancer. Urology 62:69–78. https://doi.org/10.1016/j.urology.2003.09.001
doi: 10.1016/j.urology.2003.09.001
pubmed: 14747044
van den Cornford P, Van den Briers E, Cumberbatch MG, De Santis M et al EAU-EANM-ESTRO-ESUR-SIOG guidelines on prostate Cancer. Part II—2020 update: treatment of relapsing and metastatic prostate Cancer[Formula presented]. Eur Urol 2021;79. https://doi.org/10.1016/j.eururo.2020.09.046
Calleris G, Marra G, Dalmasso E, Falcone M, Karnes RJ, Morlacco A et al (2019) Is it worth to perform salvage radical prostatectomy for radio-recurrent prostate cancer? A literature review. World J Urol 37:1469–1483. https://doi.org/10.1007/s00345-019-02749-z
doi: 10.1007/s00345-019-02749-z
pubmed: 30955047
Golbari NM, Katz AE (2017) Salvage Therapy options for local prostate Cancer recurrence after primary Radiotherapy: a literature review. Curr Urol Rep 18. https://doi.org/10.1007/s11934-017-0709-4
Zdrojowy R, Dembowski J, Małkiewicz B, Tupikowski K, Krajewski W (2016) Salvage local therapy for radiation-recurrent prostate cancer-where are we? Cent Eur J Urol 69:264–270. https://doi.org/10.5173/ceju.2016.832
doi: 10.5173/ceju.2016.832
Mantica G, Chierigo F, Suardi N, Gomez Rivas J, Kasivisvanathan V, Papalia R et al (2020) Minimally invasive strategies for the treatment of prostate cancer recurrence after radiation therapy: a systematic review. Minerva Urol Nefrol 72:563–578. https://doi.org/10.23736/S0393-2249.20.03783-2
doi: 10.23736/S0393-2249.20.03783-2
pubmed: 32748617
Polanco L, Lledó E, Caño J, Gonzalez FJ, Jara J, Hernandez C (2021) accessed January 17,. Crioterapia prostática: fundamentos y principios generales - Dialnet. Arch Esp Urol 2019:72(8):816–824. https://dialnet.unirioja.es/servlet/articulo?codigo=7083515
Levy DA, Ross AE, Elshafei A, Krishnan N, Hatem A, Jones JS (2014) Definition of biochemical success following primary whole gland prostate cryoablation. J Urol 192:1380–1384. https://doi.org/10.1016/j.juro.2014.05.003
doi: 10.1016/j.juro.2014.05.003
pubmed: 24813344
Nair SM, Warner A, Lavi A, Rodrigues G, Chin J (2020) Does adding local salvage ablation therapy provide survival advantage for patients with locally recurrent prostate cancer following radiotherapy? Whole gland salvage ablation post-radiation failure in prostate cancer. Can Urol Association J 15. https://doi.org/10.5489/CUAJ.6676
Pisters LL, Rewcastle JC, Donnelly BJ, Lugnani FM, Katz AE, Jones JS (2008) Salvage prostate cryoablation: initial results from the Cryo On-Line Data Registry. J Urol 180:559–564. https://doi.org/10.1016/j.juro.2008.04.005
doi: 10.1016/j.juro.2008.04.005
pubmed: 18554664
Bomers JGR, Overduin CG, Jenniskens SFM, Cornel EB, van Lin ENJT, Sedelaar JPM et al (2020) Focal salvage MR imaging–guided cryoablation for localized prostate Cancer recurrence after Radiotherapy: 12-Month follow-up. J Vasc Interv Radiol 31:35–41. https://doi.org/10.1016/j.jvir.2019.07.001
doi: 10.1016/j.jvir.2019.07.001
pubmed: 31735483
Sanderson KM, Penson DF, Cai J, Groshen S, Stein JP, Lieskovsky G et al (2006) Salvage Radical Prostatectomy: quality of life outcomes and long-term Oncological Control of Radiorecurrent prostate Cancer. J Urol 176:2025–2032. https://doi.org/10.1016/j.juro.2006.07.075
doi: 10.1016/j.juro.2006.07.075
pubmed: 17070244
Gotto GT, Yunis LH, Vora K, Eastham JA, Scardino PT, Rabbani F (2010) Impact of prior prostate Radiation on complications after Radical Prostatectomy. J Urol 184:136–142. https://doi.org/10.1016/j.juro.2010.03.031
doi: 10.1016/j.juro.2010.03.031
pubmed: 20478594
Zargar H, Lamb AD, Rocco B, Porpiglia F, Liatsikos E, Davis J et al (2017) Salvage robotic prostatectomy for radio recurrent prostate cancer: technical challenges and outcome analysis. Minerva Urol Nefrol 69:26–37. https://doi.org/10.23736/S0393-2249.16.02797-1
doi: 10.23736/S0393-2249.16.02797-1
pubmed: 27579821
Pisters LL, Leibovici D, Blute M, Zincke H, Sebo TJ, Slezak JM et al (2009) Locally recurrent prostate Cancer after initial Radiation Therapy: a comparison of Salvage Radical Prostatectomy Versus Cryotherapy. J Urol 182:517–527. https://doi.org/10.1016/j.juro.2009.04.006
doi: 10.1016/j.juro.2009.04.006
pubmed: 19524984