Modeling Lewy body disease with

Humans alpha-Synuclein / metabolism Organoids / metabolism Induced Pluripotent Stem Cells / metabolism Lewy Body Disease / pathology Mitochondria / metabolism Neurons / metabolism Cerebral Cortex / metabolism Drug Evaluation, Preclinical

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
13 Sep 2024
Historique:
medline: 11 9 2024
pubmed: 11 9 2024
entrez: 11 9 2024
Statut: ppublish

Résumé

Aggregated α-synuclein (α-SYN) proteins, encoded by the

Identifiants

DOI: 10.1126/sciadv.adk3700 PMID: 39259788
pubmed: 39259788
doi: 10.1126/sciadv.adk3700
doi:

Substances chimiques

alpha-Synuclein 0
SNCA protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadk3700

Auteurs

Yunjung Jin (Y)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-7701-2371

Fuyao Li (F)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-3986-2412

Zonghua Li (Z)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0001-5242-9608

Tadafumi C Ikezu (TC)

Department of Clinical Trials and Biostatistics, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-3511-6009

Justin O'Leary (J)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-7538-8455

Manikandan Selvaraj (M)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

Yiyang Zhu (Y)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-0272-1915

Yuka A Martens (YA)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-5194-4269

Shunsuke Koga (S)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0001-8868-9700

Hannah Santhakumar (H)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0009-0008-4851-4437

Yonghe Li (Y)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0003-3489-6362

Wenyan Lu (W)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

Yang You (Y)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0003-0574-7827

Kiara Lolo (K)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0009-0008-7939-8977

Michael DeTure (M)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-4363-1262

Alexandra I Beasley (AI)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-0153-1917

Mary D Davis (MD)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-2123-4688

Pamela J McLean (PJ)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0003-4870-5715

Owen A Ross (OA)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0003-4813-756X

Takahisa Kanekiyo (T)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0001-6751-9374

Tsuneya Ikezu (T)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-3979-8596

Thomas Caulfield (T)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-1055-3069

Jonathan Carr (J)

Tygerberg Hospital and University of Stellenbosch, Tygerberg 7505, South Africa.
ORCID: 0000-0002-7677-426X

Zbigniew K Wszolek (ZK)

Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0001-5487-1053

Guojun Bu (G)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0003-3491-1016

Dennis W Dickson (DW)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0001-7189-7917

Na Zhao (N)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
ORCID: 0000-0001-8648-9422

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Modeling Lewy body disease with
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Modeling Lewy body disease with
questionsmedicales.fr › Tissus › Organoïdes › Modeling Lewy body disease with
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Modeling Lewy body disease with
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie à corps de Lewy › Modeling Lewy body disease with
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Modeling Lewy body disease with
questionsmedicales.fr › Cellules › Neurones › Modeling Lewy body disease with
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Modeling Lewy body disease with
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Modeling Lewy body disease with