Impaired fibrinolysis in JAK2V617F-related myeloproliferative neoplasms.
JAK2V617F mutation
fibrin clot
fibrinolysis
myeloproliferative neoplasms
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
09 Sep 2024
09 Sep 2024
Historique:
received:
06
03
2024
revised:
30
07
2024
accepted:
30
07
2024
medline:
12
9
2024
pubmed:
12
9
2024
entrez:
11
9
2024
Statut:
aheadofprint
Résumé
Myeloproliferative neoplasms (MPN) are characterized by a high rate of thrombotic complications that contribute to morbi-mortality. MPN-related thrombogenesis is assumed to be multifactorial involving both pro-coagulant and pro-inflammatory processes. Whether impaired fibrinolysis also participates in the pro-thrombotic phenotype of MPN has been poorly investigated. We determined whether MPN, particularly JAK2V617F-positive MPN, are associated with fibrinolytic changes. Tissue plasminogen activator (tPA)-mediated fibrinolysis was evaluated both in whole blood (WB) and plasma from mice with a hematopoietic-restricted Jak2 In WB from Jak2 Our results suggest that impaired tPA-mediated fibrinolysis represents an important pro-thrombotic mechanism in MPN patients that requires confirmation on larger studies.
Sections du résumé
BACKGROUND
BACKGROUND
Myeloproliferative neoplasms (MPN) are characterized by a high rate of thrombotic complications that contribute to morbi-mortality. MPN-related thrombogenesis is assumed to be multifactorial involving both pro-coagulant and pro-inflammatory processes. Whether impaired fibrinolysis also participates in the pro-thrombotic phenotype of MPN has been poorly investigated.
OBJECTIVES
OBJECTIVE
We determined whether MPN, particularly JAK2V617F-positive MPN, are associated with fibrinolytic changes.
PATIENTS
METHODS
Tissue plasminogen activator (tPA)-mediated fibrinolysis was evaluated both in whole blood (WB) and plasma from mice with a hematopoietic-restricted Jak2
RESULTS
RESULTS
In WB from Jak2
CONCLUSIONS
CONCLUSIONS
Our results suggest that impaired tPA-mediated fibrinolysis represents an important pro-thrombotic mechanism in MPN patients that requires confirmation on larger studies.
Identifiants
pubmed: 39260744
pii: S1538-7836(24)00487-2
doi: 10.1016/j.jtha.2024.07.031
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024. Published by Elsevier Inc.