ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells.


Journal

Nature cancer
ISSN: 2662-1347
Titre abrégé: Nat Cancer
Pays: England
ID NLM: 101761119

Informations de publication

Date de publication:
11 Sep 2024
Historique:
received: 09 10 2023
accepted: 07 08 2024
medline: 12 9 2024
pubmed: 12 9 2024
entrez: 11 9 2024
Statut: aheadofprint

Résumé

Despite recent advances in immunotherapies targeting single tumor-associated antigens, patients with multiple myeloma eventually relapse. ISB 2001 is a CD3

Identifiants

pubmed: 39261676
doi: 10.1038/s43018-024-00821-1
pii: 10.1038/s43018-024-00821-1
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Laura Carretero-Iglesia (L)

Ichnos Glenmark Innovation, New York, NY, USA.

Olivia J Hall (OJ)

Ichnos Glenmark Innovation, New York, NY, USA.

Jérémy Berret (J)

Ichnos Glenmark Innovation, New York, NY, USA.

Daniela Pais (D)

Ichnos Glenmark Innovation, New York, NY, USA.

Carole Estoppey (C)

Ichnos Glenmark Innovation, New York, NY, USA.

Myriam Chimen (M)

Ichnos Glenmark Innovation, New York, NY, USA.

Thierry Monney (T)

Ichnos Glenmark Innovation, New York, NY, USA.

Jeremy Loyau (J)

Ichnos Glenmark Innovation, New York, NY, USA.

Cyrille Dreyfus (C)

Ichnos Glenmark Innovation, New York, NY, USA.

Julie Macoin (J)

Ichnos Glenmark Innovation, New York, NY, USA.

Cynthia Perez (C)

Ichnos Glenmark Innovation, New York, NY, USA.

Vinu Menon (V)

Ichnos Glenmark Innovation, New York, NY, USA.

Isabelle Gruber (I)

Ichnos Glenmark Innovation, New York, NY, USA.

Amélie Laurendon (A)

Ichnos Glenmark Innovation, New York, NY, USA.

Lydia N Caro (LN)

Ichnos Glenmark Innovation, New York, NY, USA.

Girish S Gudi (GS)

Ichnos Glenmark Innovation, New York, NY, USA.

Tomomi Matsuura (T)

Certara UK Limited, Canterbury Innovation Centre, University Road, Canterbury, United Kingdom.

Piet H van der Graaf (PH)

Certara UK Limited, Canterbury Innovation Centre, University Road, Canterbury, United Kingdom.

Stanislas Blein (S)

Ichnos Glenmark Innovation, New York, NY, USA.

M Lamine Mbow (ML)

Ichnos Glenmark Innovation, New York, NY, USA.

Rebecca Croasdale-Wood (R)

Ichnos Glenmark Innovation, New York, NY, USA.

Ankita Srivastava (A)

Ichnos Glenmark Innovation, New York, NY, USA.

Michael R Dyson (MR)

Ichnos Glenmark Innovation, New York, NY, USA.

Thomas Matthes (T)

Hematology Service, Department of Oncology and Clinical Pathology Service, Department of Diagnostics, University Hospital Geneva, Geneva, Switzerland.

Zeynep Kaya (Z)

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Institute, University of Oxford, Oxford, United Kingdom.

Claire M Edwards (CM)

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Institute, University of Oxford, Oxford, United Kingdom.

James R Edwards (JR)

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Institute, University of Oxford, Oxford, United Kingdom.

Sophie Maiga (S)

Nantes Université, Inserm, CNRS, Université d'Angers, Nantes, France.
SIRIC ILIAD, Angers, Nantes, France.

Catherine Pellat-Deceunynck (C)

Nantes Université, Inserm, CNRS, Université d'Angers, Nantes, France.
SIRIC ILIAD, Angers, Nantes, France.

Cyrille Touzeau (C)

Nantes Université, Inserm, CNRS, Université d'Angers, Nantes, France.
SIRIC ILIAD, Angers, Nantes, France.
Service d'Hématologie Clinique, Unité d'Investigation Clinique, CHU, Nantes, France.

Philippe Moreau (P)

Nantes Université, Inserm, CNRS, Université d'Angers, Nantes, France.
SIRIC ILIAD, Angers, Nantes, France.
Service d'Hématologie Clinique, Unité d'Investigation Clinique, CHU, Nantes, France.

Cyril Konto (C)

Ichnos Glenmark Innovation, New York, NY, USA.

Adam Drake (A)

Ichnos Glenmark Innovation, New York, NY, USA.

Eugene A Zhukovsky (EA)

Ichnos Glenmark Innovation, New York, NY, USA.

Mario Perro (M)

Ichnos Glenmark Innovation, New York, NY, USA. mario.perro@iginnovate.com.

Maria Pihlgren (M)

Ichnos Glenmark Innovation, New York, NY, USA.

Classifications MeSH