Long-term zinc treatment alters the mechanical properties and metabolism of prostate cancer cells.
Actin
Cancer
Cytoskeleton
Mechanobiology
Metabolism
Mitochondria
Vimentin
Zinc
Journal
Cancer cell international
ISSN: 1475-2867
Titre abrégé: Cancer Cell Int
Pays: England
ID NLM: 101139795
Informations de publication
Date de publication:
11 Sep 2024
11 Sep 2024
Historique:
received:
23
04
2024
accepted:
30
08
2024
medline:
12
9
2024
pubmed:
12
9
2024
entrez:
11
9
2024
Statut:
epublish
Résumé
The failure of intracellular zinc accumulation is a key process in prostate carcinogenesis. Although prostate cancer cells can accumulate zinc after long-term exposure, chronic zinc oversupply may accelerate prostate carcinogenesis or chemoresistance. Because cancer progression is associated with energetically demanding cytoskeletal rearrangements, we investigated the effect of long-term zinc presence on biophysical parameters, ATP production, and EMT characteristics of two prostate cancer cell lines (PC-3, 22Rv1). Prolonged exposure to zinc increased ATP production, spare respiratory capacity, and induced a response in PC-3 cells, characterized by remodeling of vimentin and a shift of cell dry mass density and caveolin-1 to the perinuclear region. This zinc-induced remodeling correlated with a greater tendency to maintain actin architecture despite inhibition of actin polymerization by cytochalasin. Zinc partially restored epithelial characteristics in PC-3 cells by decreasing vimentin expression and increasing E-cadherin. Nevertheless, the expression of E-cadherin remained lower than that observed in predominantly oxidative, low-invasive 22Rv1 cells. Following long-term zinc exposure, we observed an increase in cell stiffness associated with an increased refractive index in the perinuclear region and an increased mitochondrial content. The findings of the computational simulations indicate that the mechanical response cannot be attributed exclusively to alterations in cytoskeletal composition. This observation suggests the potential involvement of an additional, as yet unidentified, mechanical contributor. These findings indicate that long-term zinc exposure alters a group of cellular parameters towards an invasive phenotype, including an increase in mitochondrial number, ATP production, and cytochalasin resistance. Ultimately, these alterations are manifested in the biomechanical properties of the cells.
Identifiants
pubmed: 39261823
doi: 10.1186/s12935-024-03495-y
pii: 10.1186/s12935-024-03495-y
doi:
Types de publication
Journal Article
Langues
eng
Pagination
313Subventions
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : NU22J-08-00062
Informations de copyright
© 2024. The Author(s).
Références
Costello LC, Franklin RB. A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer. Arch Biochem Biophys. 2016;611:100–12.
pubmed: 27132038
pmcid: 5083243
doi: 10.1016/j.abb.2016.04.014
Costello LC, Liu YY, Franklin RB, Kennedy MC. Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells. J Biol Chem. 1997;272:28875–81.
pubmed: 9360955
doi: 10.1074/jbc.272.46.28875
Ahmad F, Cherukuri MK, Choyke PL. Metabolic reprogramming in prostate cancer. Br J Cancer. 2021;125:1185–96.
pubmed: 34262149
pmcid: 8548338
doi: 10.1038/s41416-021-01435-5
Youssef KK, Nieto MA. Glucose metabolism takes center stage in epithelial-mesenchymal plasticity. Dev Cell. 2020;53:133–5.
pubmed: 32315608
doi: 10.1016/j.devcel.2020.03.021
Massey A, Stewart J, Smith C, Parvini C, McCormick M, Do K, et al. Mechanical properties of human tumour tissues and their implications for cancer development. Nat Rev Phys. 2024;6:1–14.
doi: 10.1038/s42254-024-00707-2
Montanari M, Rossetti S, Cavaliere C, D’Aniello C, Malzone MG, Vanacore D, et al. Epithelial-mesenchymal transition in prostate cancer: an overview. Oncotarget. 2017;8:35376–89.
pubmed: 28430640
pmcid: 5471062
doi: 10.18632/oncotarget.15686
Terry S, El-Sayed YI, Destouches D, Maillé P, Nicolaiew N, Ploussard G, et al. CRIPTO overexpression promotes mesenchymal differentiation in prostate carcinoma cells through parallel regulation of AKT and FGFR activities. Oncotarget. 2015. https://doi.org/10.18632/oncotarget.2740 .
doi: 10.18632/oncotarget.2740
pubmed: 25596738
pmcid: 4494918
Bailey KM, Liu J. Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase. J Biol Chem. 2008;283:13714–24.
pubmed: 18332144
pmcid: 2376249
doi: 10.1074/jbc.M709329200
Kamibeppu T, Yamasaki K, Nakahara K, Nagai T, Terada N, Tsukino H, et al. Caveolin-1 and -2 regulate cell motility in castration-resistant prostate cancer. Res Rep Urol. 2018;10:135–44.
pubmed: 30324095
pmcid: 6174915
Holubova M, Axmanova M, Gumulec J, Raudenska M, Sztalmachova M, Babula P, et al. KRAS NF-kappa B is involved in the development of zinc resistance and reduced curability in prostate cancer. Metallomics. 2014;6:1240–53.
pubmed: 24927480
doi: 10.1039/c4mt00065j
Kratochvilova M, Raudenska M, Heger Z, Richtera L, Cernei N, Adam V, et al. Amino acid profiling of zinc resistant prostate cancer cell lines: associations with cancer progression. Prostate. 2017;77:604–16.
pubmed: 28101932
doi: 10.1002/pros.23304
Ninsontia C, Phiboonchaiyanan PP, Chanvorachote P. Zinc induces epithelial to mesenchymal transition in human lung cancer H460 cells via superoxide anion-dependent mechanism. Cancer Cell Int. 2016;16:48.
pubmed: 27330411
pmcid: 4912812
doi: 10.1186/s12935-016-0323-4
Xue YN, Yu BB, Liu YN, Guo R, Li JL, Zhang LC, et al. Zinc promotes prostate cancer cell chemosensitivity to paclitaxel by inhibiting epithelial-mesenchymal transition and inducing apoptosis. Prostate. 2019;79:647–56.
pubmed: 30714183
doi: 10.1002/pros.23772
Fraser M, Zhao H, Luoto KR, Lundin C, Coackley C, Chan N, et al. PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: implications for radiotherapy and chemotherapy. Clin Cancer Res. 2012;18:1015–27.
pubmed: 22114138
doi: 10.1158/1078-0432.CCR-11-2189
Gumulec J, Balvan J, Sztalmachova M, Raudenska M, Dvorakova V, Knopfova L, et al. Cisplatin-resistant prostate cancer model: differences in antioxidant system, apoptosis and cell cycle. Int J Oncol. 2014;44:923–33.
pubmed: 24366574
doi: 10.3892/ijo.2013.2223
Ni Shúilleabháin S, Mothersill C, Sheehan D, O’Brien NM, O’ Halloran J, Van Pelt FNAM, et al. In vitro cytotoxicity testing of three zinc metal salts using established fish cell lines. Toxicol In Vitro. 2004;18:365–76.
pubmed: 15046785
doi: 10.1016/j.tiv.2003.10.006
Bansod YD, Matsumoto T, Nagayama K, Bursa J. A finite element bendo-tensegrity model of eukaryotic cell. J Biomech Eng. 2018. https://doi.org/10.1115/1.4040246 .
doi: 10.1115/1.4040246
pubmed: 30029237
Jakka VVSV, Bursa J. Finite element simulations of mechanical behaviour of endothelial cells. BioMed Res Int. 2021;2021: e8847372.
doi: 10.1155/2021/8847372
Rosendahl P, Plak K, Jacobi A, Kraeter M, Toepfner N, Otto O, et al. Real-time fluorescence and deformability cytometry. Nat Methods. 2018;15:355–8.
pubmed: 29608556
doi: 10.1038/nmeth.4639
Peltanova B, Polanska HH, Raudenska M, Balvan J, Navratil J, Vicar T, et al. mRNA subtype of cancer-associated fibroblasts significantly affects key characteristics of head and neck cancer cells. Cancers. 2022;14:2286.
pubmed: 35565415
pmcid: 9102192
doi: 10.3390/cancers14092286
Vicar T, Chmelik J, Navratil J, Kolar R, Chmelikova L, Cmiel V, et al. Cancer cell viscoelasticity measurement by quantitative phase and flow stress induction. Biophys J. 2022;121:1632–42.
pubmed: 35390297
pmcid: 9117928
doi: 10.1016/j.bpj.2022.04.002
Wiśniewski JR, Ostasiewicz P, Mann M. High recovery FASP applied to the proteomic analysis of microdissected formalin fixed paraffin embedded cancer tissues retrieves known colon cancer markers. J Proteome Res. 2011;10:3040–9.
pubmed: 21526778
doi: 10.1021/pr200019m
Kim K, Guck J. The relative densities of cytoplasm and nuclear compartments are robust against strong perturbation. Biophys J. 2020;119:1946–57.
pubmed: 33091376
pmcid: 7732746
doi: 10.1016/j.bpj.2020.08.044
Hanelova K, Raudenska M, Kratochvilova M, Navratil J, Vicar T, Bugajova M, et al. Autophagy modulators influence the content of important signalling molecules in PS-positive extracellular vesicles. Cell Commun Signal. 2023;21:120.
pubmed: 37226246
pmcid: 10210466
doi: 10.1186/s12964-023-01126-z
Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation. 2021;2: 100141.
pubmed: 34557778
pmcid: 8454663
Blighe K, Rana S, Lewis M. EnhancedVolcano: publication-ready volcano plots with enhanced colouring and labeling. 2022.
Kolde R. pheatmap: Pretty Heatmaps. 2019.
Wickham H. ggplot2: elegant graphics for data analysis. New York: Springer-Verlag; 2016.
doi: 10.1007/978-3-319-24277-4
Dowle M, Srinivasan A. data.table: Extension of `data.frame`. 2023.
Wang Q, Shi L, Shi K, Yuan B, Cao G, Kong C, et al. CircCSPP1 functions as a ceRNA to promote colorectal carcinoma cell EMT and liver metastasis by upregulating COL1A1. Front Oncol. 2020;10:850.
pubmed: 32612946
pmcid: 7308451
doi: 10.3389/fonc.2020.00850
Hu J, Guan W, Yan L, Ye Z, Wu L, Xu H. Cancer stem cell marker endoglin (CD105) induces epithelial mesenchymal transition (EMT) but not metastasis in clear cell renal cell carcinoma. Stem Cells Int. 2019;2019:9060152.
pubmed: 31015843
pmcid: 6444238
doi: 10.1155/2019/9060152
Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119:1420–8.
pubmed: 19487818
pmcid: 2689101
doi: 10.1172/JCI39104
Liu M, Qi Y, Zhao L, Chen D, Zhou Y, Zhou H, et al. Matrix metalloproteinase-14 induces epithelial-to-mesenchymal transition in synovial sarcoma. Hum Pathol. 2018;80:201–9.
pubmed: 29935194
doi: 10.1016/j.humpath.2017.12.031
Chi Q, Xu H, Song D, Wang Z, Ma G. α-E-Catenin (CTNNA1) inhibits cell proliferation, invasion and EMT of bladder cancer. Cancer Manag Res. 2020;12:12747–58.
pubmed: 33364826
pmcid: 7751797
doi: 10.2147/CMAR.S259269
Slabý T, Křížová A, Lošt’ák M, Čolláková J, Jůzová V, Veselý P, et al. Coherence-controlled holographic microscopy for live-cell quantitative phase imaging. In: Quantitative Phase Imaging. SPIE; 2015. p. 45–8.
Bon P, Lécart S, Fort E, Lévêque-Fort S. Fast label-free cytoskeletal network imaging in living mammalian cells. Biophys J. 2014;106:1588–95.
pubmed: 24739158
pmcid: 4008798
doi: 10.1016/j.bpj.2014.02.023
Eriksson JE, He T, Trejo-Skalli AV, Härmälä-Braskén AS, Hellman J, Chou YH, et al. Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments. J Cell Sci. 2004;117(Pt 6):919–32.
pubmed: 14762106
doi: 10.1242/jcs.00906
Leitzmann MF, Stampfer MJ, Wu K, Colditz GA, Willett WC, Giovannucci EL. Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst. 2003;95:1004–7.
pubmed: 12837837
doi: 10.1093/jnci/95.13.1004
Moreno-Vicente R, Pavón DM, Martín-Padura I, Català-Montoro M, Díez-Sánchez A, Quílez-Álvarez A, et al. Caveolin-1 modulates mechanotransduction responses to substrate stiffness through actin-dependent control of YAP. Cell Rep. 2018;25:1622-1635.e6.
pubmed: 30404014
pmcid: 6231326
doi: 10.1016/j.celrep.2018.10.024
Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009;139:891–906.
pubmed: 19931152
pmcid: 2788004
doi: 10.1016/j.cell.2009.10.027
Zanotelli MR, Goldblatt ZE, Miller JP, Bordeleau F, Li J, VanderBurgh JA, et al. Regulation of ATP utilization during metastatic cell migration by collagen architecture. Mol Biol Cell. 2018;29:1–9.
pubmed: 29118073
pmcid: 5746062
doi: 10.1091/mbc.E17-01-0041
Lin C, Salzillo TC, Bader DA, Wilkenfeld SR, Awad D, Pulliam TL, et al. Prostate cancer energetics and biosynthesis. Adv Exp Med Biol. 2019;1210:185–237.
pubmed: 31900911
pmcid: 8096614
doi: 10.1007/978-3-030-32656-2_10
Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M. Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther. 2019;18:693–705.
pubmed: 30824582
doi: 10.1158/1535-7163.MCT-18-0766
Nickens KP, Wikstrom JD, Shirihai OS, Patierno SR, Ceryak S. A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity. Mitochondrion. 2013;13:662–7.
pubmed: 24075934
doi: 10.1016/j.mito.2013.09.005
Vayalil PK. Mitochondrial oncobioenergetics of prostate tumorigenesis. Oncol Lett. 2019;18:4367–76.
pubmed: 31611945
pmcid: 6781517
Sriskanthadevan S, Jeyaraju DV, Chung TE, Prabha S, Xu W, Skrtic M, et al. AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress. Blood. 2015;125:2120–30.
pubmed: 25631767
pmcid: 4375109
doi: 10.1182/blood-2014-08-594408
Sasagawa S, Nishimura Y, Okabe S, Murakami S, Ashikawa Y, Yuge M, et al. Downregulation of GSTK1 is a common mechanism underlying hypertrophic cardiomyopathy. Front Pharmacol. 2016;7:162.
pubmed: 27378925
pmcid: 4905960
doi: 10.3389/fphar.2016.00162
Malvi P, Janostiak R, Nagarajan A, Zhang X, Wajapeyee N. N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production. Mol Metab. 2021;48: 101217.
pubmed: 33766731
pmcid: 8081993
doi: 10.1016/j.molmet.2021.101217
Zaidi SK, Shen W-J, Cortez Y, Bittner S, Bittner A, Arshad S, et al. SOD2 deficiency-induced oxidative stress attenuates steroidogenesis in mouse ovarian granulosa cells. Mol Cell Endocrinol. 2021;519: 110888.
pubmed: 32717420
doi: 10.1016/j.mce.2020.110888
Chen C-L, Hsu S-C, Chung T-Y, Chu C-Y, Wang H-J, Hsiao P-W, et al. Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells. Nat Commun. 2021;12:2398.
pubmed: 33893278
pmcid: 8065123
doi: 10.1038/s41467-021-22652-9
Long Y, Tsai WB, Wang D, Hawke DH, Savaraj N, Feun LG, et al. Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy. Cancer Lett. 2017;388:54–63.
pubmed: 27913198
doi: 10.1016/j.canlet.2016.11.028
Keshet R, Lee JS, Adler L, Iraqi M, Ariav Y, Lim LQJ, et al. Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors. Nat Cancer. 2020;1:894–908.
pubmed: 35121952
doi: 10.1038/s43018-020-0106-7
Stock C, Pedersen SF. Roles of pH and the Na(+)/H(+) exchanger NHE1 in cancer: from cell biology and animal models to an emerging translational perspective? Semin Cancer Biol. 2017;43:5–16.
pubmed: 28007556
doi: 10.1016/j.semcancer.2016.12.001
Keurhorst D, Liashkovich I, Frontzek F, Nitzlaff S, Hofschröer V, Dreier R, et al. MMP3 activity rather than cortical stiffness determines NHE1-dependent invasiveness of melanoma cells. Cancer Cell Int. 2019;19:285.
pubmed: 31728131
pmcid: 6842528
doi: 10.1186/s12935-019-1015-7
Affronti HC, Rowsam AM, Pellerite AJ, Rosario SR, Long MD, Jacobi JJ, et al. Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy. Nat Commun. 2020;11:52.
pubmed: 31911608
pmcid: 6946658
doi: 10.1038/s41467-019-13950-4
Hua W, ten Dijke P, Kostidis S, Giera M, Hornsveld M. TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer. Cell Mol Life Sci. 2020;77:2103–23.
pubmed: 31822964
doi: 10.1007/s00018-019-03398-6
Durante W, Liao L, Reyna SV, Peyton KJ, Schafer AI. Transforming growth factor-β1 stimulates l-arginine transport and metabolism in vascular smooth muscle cells. Circulation. 2001;103:1121–7.
pubmed: 11222476
doi: 10.1161/01.CIR.103.8.1121
Bian T, Zheng L, Jiang D, Liu J, Zhang J, Feng J, et al. Overexpression of fibronectin type III domain containing 3B is correlated with epithelial-mesenchymal transition and predicts poor prognosis in lung adenocarcinoma. Exp Ther Med. 2019;17:3317–26.
pubmed: 30988707
pmcid: 6447801
Li B, Shen W, Peng H, Li Y, Chen F, Zheng L, et al. Fibronectin 1 promotes melanoma proliferation and metastasis by inhibiting apoptosis and regulating EMT. Onco Targets Ther. 2019;12:3207–21.
pubmed: 31118673
pmcid: 6503329
doi: 10.2147/OTT.S195703
Fontana F, Raimondi M, Marzagalli M, Sommariva M, Limonta P, Gagliano N. Epithelial-to-mesenchymal transition markers and CD44 isoforms are differently expressed in 2D and 3D cell cultures of prostate cancer cells. Cells. 2019;8:143.
pubmed: 30754655
pmcid: 6406374
doi: 10.3390/cells8020143
Zhang R, Zhao G, Shi H, Zhao X, Wang B, Dong P, et al. Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition. Free Radic Biol Med. 2020;160:775–83.
pubmed: 32927017
pmcid: 7704937
doi: 10.1016/j.freeradbiomed.2020.09.010
Sun L, Wang Y, Zhang H, Min C, Zhang Y, Zhang C, et al. Graphene-based confocal refractive index microscopy for label-free differentiation of living epithelial and mesenchymal cells. ACS Sens. 2020;5:510–8.
pubmed: 31927913
doi: 10.1021/acssensors.9b02340
Grupp K, Jedrzejewska K, Tsourlakis MC, Koop C, Wilczak W, Adam M, et al. High mitochondria content is associated with prostate cancer disease progression. Mol Cancer. 2013;12:145.
pubmed: 24261794
pmcid: 3842770
doi: 10.1186/1476-4598-12-145
Jansen KA, Donato DM, Balcioglu HE, Schmidt T, Danen EH, Koenderink GH. A guide to mechanobiology: where biology and physics meet. Biochim Biophys Acta BBA-Mol Cell Res. 2015;1853:3043–52.
doi: 10.1016/j.bbamcr.2015.05.007
Mendez M, Restle D, Janmey P. Vimentin enhances cell elastic behavior and protects against compressive stress. Biophys J. 2014;107:314–23.
pubmed: 25028873
pmcid: 4104054
doi: 10.1016/j.bpj.2014.04.050
Janmey PA, Euteneuer U, Traub P, Schliwa M. Viscoelastic properties of vimentin compared with other filamentous biopolymer networks. J Cell Biol. 1991;113:155–60.
pubmed: 2007620
doi: 10.1083/jcb.113.1.155
Wang N, Stamenović D. Contribution of intermediate filaments to cell stiffness, stiffening, and growth. Am J Physiol Cell Physiol. 2000;279:C188-194.
pubmed: 10898730
doi: 10.1152/ajpcell.2000.279.1.C188
Trendowski M. Exploiting the cytoskeletal filaments of neoplastic cells to potentiate a novel therapeutic approach. Biochim Biophys Acta BBA - Rev Cancer. 2014;1846:599–616.
doi: 10.1016/j.bbcan.2014.09.007
Angrisani A, Di Fiore A, De Smaele E, Moretti M. The emerging role of the KCTD proteins in cancer. Cell Commun Signal. 2021;19:56.
pubmed: 34001146
pmcid: 8127222
doi: 10.1186/s12964-021-00737-8
Freire-Benéitez V, Pomella N, Millner TO, Dumas AA, Niklison-Chirou MV, Maniati E, et al. Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma. NAR Cancer. 2021;3: zcab009.
pubmed: 34316702
pmcid: 8210184
doi: 10.1093/narcan/zcab009
Yang Z, Liao J, Cullen KJ, Dan H. Inhibition of IKKβ/NF-κB signaling pathway to improve Dasatinib efficacy in suppression of cisplatin-resistant head and neck squamous cell carcinoma. Cell Death Discov. 2020;6:36.
pubmed: 32435511
pmcid: 7229171
doi: 10.1038/s41420-020-0270-7
Zhu Z, Mu Y, Qi C, Wang J, Xi G, Guo J, et al. CYP1B1 enhances the resistance of epithelial ovarian cancer cells to paclitaxel in vivo and in vitro. Int J Mol Med. 2015;35:340–8.
pubmed: 25516145
doi: 10.3892/ijmm.2014.2041
Zhang Y, Jiang C, Li H, Lv F, Li X, Qian X, et al. Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer. Int J Clin Exp Pathol. 2015;8:751–7.
pubmed: 25755770
pmcid: 4348845
Xiu MX, Liu YM. The role of oncogenic Notch2 signaling in cancer: a novel therapeutic target. Am J Cancer Res. 2019;9:837–54.
pubmed: 31218097
pmcid: 6556604
Pan LN, Zhang Y, Zhu CJ, Dong ZX. Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein. J Zhejiang Univ Sci B. 2017;18:1046–54.
pubmed: 29204984
pmcid: 5742287
doi: 10.1631/jzus.B1700129
Chien C-H, Chuang J-Y, Yang S-T, Yang W-B, Chen P-Y, Hsu T-I, et al. Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets. J Biomed Sci. 2019;26:77.
pubmed: 31629402
pmcid: 6800988
doi: 10.1186/s12929-019-0565-2
Chakraborty AR, Vassilev A, Jaiswal SK, O’Connell CE, Ahrens JF, Mallon BS, et al. Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors. Stem Cell Rep. 2022;17:397–412.
doi: 10.1016/j.stemcr.2021.12.013
Carlier MF, Criquet P, Pantaloni D, Korn ED. Interaction of cytochalasin D with actin filaments in the presence of ADP and ATP. J Biol Chem. 1986;261:2041–50.
pubmed: 3944126
doi: 10.1016/S0021-9258(17)35894-5
Shi X, Fan C, Jiu Y. Unidirectional regulation of vimentin intermediate filaments to caveolin-1. Int J Mol Sci. 2020;21:7436.
pubmed: 33050149
pmcid: 7650580
doi: 10.3390/ijms21207436
Jiu Y. Vimentin intermediate filaments function as a physical barrier during intracellular trafficking of caveolin-1. Biochem Biophys Res Commun. 2018;507:161–7.
pubmed: 30415776
doi: 10.1016/j.bbrc.2018.10.199
Wang X, Lu B, Dai C, Fu Y, Hao K, Zhao B, et al. Caveolin-1 promotes chemoresistance of gastric cancer cells to cisplatin by activating WNT/β-Catenin pathway. Front Oncol. 2020. https://doi.org/10.3389/fonc.2020.00046 .
doi: 10.3389/fonc.2020.00046
pubmed: 34079750
pmcid: 7787074
Wang Z, Yu Z, Wang GH, Zhou YM, Deng JP, Feng Y, et al. AURKB promotes the metastasis of gastric cancer, possibly by inducing EMT. Cancer Manag Res. 2020;12:6947–58.
pubmed: 32801915
pmcid: 7415439
doi: 10.2147/CMAR.S254250
Mangolini M, Götte F, Moore A, Ammon T, Oelsner M, Lutzny-Geier G, et al. Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018;9:3839.
pubmed: 30242258
pmcid: 6155045
doi: 10.1038/s41467-018-06069-5