Dye-Based Fluorescent Organic Nanoparticles, New Promising Tools for Optogenetics.
closed‐loop
fluorescence
neurostimulation
optogenetic
organic nanoparticles
two‐photon absorption
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
12 Sep 2024
12 Sep 2024
Historique:
revised:
02
08
2024
received:
10
06
2024
medline:
12
9
2024
pubmed:
12
9
2024
entrez:
12
9
2024
Statut:
aheadofprint
Résumé
Dye-based fluorescent organic nanoparticles are a specific class of nanoparticles obtained by nanoprecipitation in water of pure dyes only. While the photophysical and colloidal properties of the nanoparticles strongly depend on the nature of the aggregated dyes, their excellent brightness in the visible and in the near infrared make these nanoparticles a unique and versatile platform for in vivo application. This article examines the promising utilization of these nanoparticles for in vivo optogenetics applications. Their photophysical properties as well as their biocompatibility and their capacity to activate Chrimson opsin in vivo through the fluorescence reabsorption process are demonstrated. Additionally, an illustrative example of employing these nanoparticles in fear reduction in mice through closed-loop stimulation is presented. Through an optogenetic methodology, the nanoparticles demonstrate an ability to selectively manipulate neurons implicated in the fear response and diminish the latter. Dye-based fluorescent organic nanoparticles represent a promising and innovative strategy for optogenetic applications, holding substantial potential in the domain of translational neuroscience. This work paves the way for novel therapeutic modalities for neurological and neuropsychiatric disorders.
Identifiants
pubmed: 39263839
doi: 10.1002/adhm.202402132
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2402132Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-22-CE18-0035-02
Organisme : Université de Bordeaux
Informations de copyright
© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.
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