Dissecting the metabolic signaling pathways by which microbial molecules drive the differentiation of regulatory B cells.
NF-kB
Regulatory B cells
colitis
microbial metabolites
microbiota
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
10 Sep 2024
10 Sep 2024
Historique:
received:
05
03
2024
revised:
06
09
2024
accepted:
09
09
2024
medline:
13
9
2024
pubmed:
13
9
2024
entrez:
12
9
2024
Statut:
aheadofprint
Résumé
The host-microbiome axis has been implicated in promoting anti-inflammatory immune responses. Yet, the underlying molecular mechanisms of commensal-mediated IL-10 production by regulatory B cells (Bregs) are not fully elucidated. Here, we demonstrate that bacterial CpG motifs trigger the signaling downstream of TLR9 promoting IκB
Identifiants
pubmed: 39265892
pii: S1933-0219(24)00096-5
doi: 10.1016/j.mucimm.2024.09.003
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.