In Enzymatic Reactions, the Reverse Reaction Reduces Product Noise.

Enzymatic reactions are essential for most cellular reactions and ubiquitous in living organisms. In the present study, we explore the pivotal role of the reverse reaction in enzymatic reactions. It is a powerful noise-buffering motif. By SSA (stochastic simulation algorithm), a remarkable 32% reduction of product CV (coefficient of variation) was observed. To better understand the causes, we split the upstream noise. The product CV reduction is more than 35% for the noise inherited from the enzyme but merely 6% to 21% for that from the substrate. It implies that the system applies different strategies to different upstream noises. We identified two leading causes responsible for noise attenuation. A cell is well designed to control its intracellular noise, and to acquire wisdom from nature is always enjoyable.

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Declaration of Competing Interest ☐ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☒ The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Che-Chi Shu reports financial support was provided by National Science and Technology Council. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.