Neural basis of false recognition in Alzheimer's disease and dementia with lewy bodies.
Humans
Alzheimer Disease
/ diagnostic imaging
Lewy Body Disease
/ diagnostic imaging
Male
Female
Aged
Magnetic Resonance Imaging
/ methods
Aged, 80 and over
Brain
/ diagnostic imaging
Gray Matter
/ diagnostic imaging
Recognition, Psychology
/ physiology
Hippocampus
/ diagnostic imaging
Parahippocampal Gyrus
/ diagnostic imaging
Alzheimer’s Disease Assessment Scale
Alzheimer’s dementia
Dementia with Lewy bodies
False recognition
Statistical parametric mapping
Voxel-based morphometry
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 Sep 2024
12 Sep 2024
Historique:
received:
16
04
2024
accepted:
28
08
2024
medline:
13
9
2024
pubmed:
13
9
2024
entrez:
12
9
2024
Statut:
epublish
Résumé
In Alzheimer's disease (AD), reports on the association between false recognition and brain structure have been inconsistent. In dementia with Lewy bodies (DLB), no such association has been reported. This study aimed to identify brain regions associated with false recognition in AD and DLB by analyzing regional gray matter volume (rGMV). We included 184 patients with AD and 60 patients with DLB. The number of false recognitions was assessed using the Alzheimer's Disease Assessment Scale' word recognition task. Brain regions associated with the number of false recognitions were examined by voxel-based morphometry analysis. The number of false recognitions significantly negatively correlated with rGMV in the bilateral hippocampus, left parahippocampal gyrus, bilateral amygdala, and bilateral entorhinal cortex in patients with AD (p < 0.05, family-wise error [FEW] corrected) and in the bilateral hippocampus, left parahippocampal gyrus, right inferior frontal gyrus, right middle frontal gyrus, right basal forebrain, right insula, left medial and lateral orbital gyri, and left fusiform in those with DLB (p < 0.05, FWE corrected). Bilateral hippocampus and left parahippocampal gyrus were associated with false recognition in both diseases. However, we found there were regions where the association between false recognition and rGMV differed from disease to disease.
Identifiants
pubmed: 39266605
doi: 10.1038/s41598-024-71440-0
pii: 10.1038/s41598-024-71440-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21290Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP21dk0207056
Informations de copyright
© 2024. The Author(s).
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