Evaluation of silent brain injury in patients undergoing aorto-ostial coronary stent implantation.
Aorto-ostial stenting
neuron-specific enolase
silent brain injury
Journal
Annals of medicine
ISSN: 1365-2060
Titre abrégé: Ann Med
Pays: England
ID NLM: 8906388
Informations de publication
Date de publication:
Dec 2024
Dec 2024
Historique:
medline:
15
9
2024
pubmed:
15
9
2024
entrez:
13
9
2024
Statut:
ppublish
Résumé
Aorto-ostial (AO) coronary interventions may be associated with multiple problems, including the potential embolization of atherothrombotic debris into the aorta and systemic circulation. Such embolization could theoretically lead to stroke or silent brain injury (SBI). In this study, we aimed to investigate whether there is an increased risk of SBI in patients undergoing AO stent implantation. Fifty-five consecutive patients undergoing AO stenting and 55 consecutive patients undergoing non-AO stenting were included. Venous blood samples were obtained before and 12 h after the procedure to measure neuron-specific enolase (NSE), which is a sensitive marker of brain injury. Newly developed NSE elevation after the procedure in an asymptomatic patient was defined as SBI. SBI was detected in 24 (43.6%) patients in the AO stenting group and 17 (30.9%) patients in the non-AO stenting group ( This study suggests that AO stenting may be associated with an increased risk of SBI if the lesion in the ostium is significant.
Sections du résumé
BACKGROUND
UNASSIGNED
Aorto-ostial (AO) coronary interventions may be associated with multiple problems, including the potential embolization of atherothrombotic debris into the aorta and systemic circulation. Such embolization could theoretically lead to stroke or silent brain injury (SBI). In this study, we aimed to investigate whether there is an increased risk of SBI in patients undergoing AO stent implantation.
METHODS
UNASSIGNED
Fifty-five consecutive patients undergoing AO stenting and 55 consecutive patients undergoing non-AO stenting were included. Venous blood samples were obtained before and 12 h after the procedure to measure neuron-specific enolase (NSE), which is a sensitive marker of brain injury. Newly developed NSE elevation after the procedure in an asymptomatic patient was defined as SBI.
RESULTS
UNASSIGNED
SBI was detected in 24 (43.6%) patients in the AO stenting group and 17 (30.9%) patients in the non-AO stenting group (
CONCLUSION
UNASSIGNED
This study suggests that AO stenting may be associated with an increased risk of SBI if the lesion in the ostium is significant.
Identifiants
pubmed: 39268588
doi: 10.1080/07853890.2024.2402950
doi:
Substances chimiques
Phosphopyruvate Hydratase
EC 4.2.1.11
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM