Family History in Parkinson's Disease: A National Cross-Sectional Study.

bipolar disorder cognitive impairment depression familial and sporadic Parkinson's disease family history hyposmia

Journal

Movement disorders clinical practice

ISSN: 2330-1619

Titre abrégé: Mov Disord Clin Pract

Pays: United States

ID NLM: 101630279

Informations de publication

Date de publication:
13 Sep 2024

Historique:

revised: 24 07 2024

received: 12 04 2024

accepted: 17 08 2024

medline: 13 9 2024

pubmed: 13 9 2024

entrez: 13 9 2024

Statut: aheadofprint

Résumé

Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect. We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD). A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected. Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group. fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.

Sections du résumé

BACKGROUND BACKGROUND

Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect.

OBJECTIVES OBJECTIVE

We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD).

METHODS METHODS

A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected.

RESULTS RESULTS

Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group.

CONCLUSIONS CONCLUSIONS

fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.

Identifiants

DOI: 10.1002/mdc3.14206 PMID: 39269187

pubmed: 39269187

doi: 10.1002/mdc3.14206

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Informations de copyright

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