Synthesis and screening of a library of Lewis
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 Sep 2024
13 Sep 2024
Historique:
received:
22
05
2024
accepted:
30
07
2024
medline:
14
9
2024
pubmed:
14
9
2024
entrez:
13
9
2024
Statut:
epublish
Résumé
Glycan-mediated interactions play a crucial role in biology and medicine, influencing signalling, immune responses, and disease pathogenesis. However, the use of glycans in biosensing and diagnostics is limited by cross-reactivity, as certain glycan motifs can be recognised by multiple biologically distinct protein receptors. To address this specificity challenge, we report the enzymatic synthesis of a 150-member library of site-specifically fluorinated Lewis
Identifiants
pubmed: 39271664
doi: 10.1038/s41467-024-51081-7
pii: 10.1038/s41467-024-51081-7
doi:
Substances chimiques
Polysaccharides
0
Lewis X Antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7925Subventions
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/M02878X/1
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/M028852/1
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/M028941/1
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/M02847X/1
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/M028976/1
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/M028747/1
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/M028836
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/M011151/1
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/V50953X/1
Organisme : Wellcome Trust (Wellcome)
ID : WT099197/Z/12/Z
Organisme : Wellcome Trust (Wellcome)
ID : 108430/Z/15/Z
Organisme : Wellcome Trust (Wellcome)
ID : 218304/Z/19/Z
Organisme : Wellcome Trust (Wellcome)
ID : 102576/Z/13/Z
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : ERC-COG: 648239
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : ProgrES-ERC-2017-ADG
Organisme : RCUK | Engineering and Physical Sciences Research Council (EPSRC)
ID : DTA1799721
Informations de copyright
© 2024. The Author(s).
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