Association between the lipid accumulation product and chronic kidney disease among adults in the United States.
Albuminuria
Chronic kidney disease
Estimated glomerular filtration rate
Lipid accumulation product
National Health and Nutrition Examination Survey
Obesity
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
13 Sep 2024
13 Sep 2024
Historique:
received:
12
06
2024
accepted:
02
09
2024
medline:
14
9
2024
pubmed:
14
9
2024
entrez:
13
9
2024
Statut:
epublish
Résumé
The objective of this research was to explore the potential association between lipid accumulation product (LAP) and chronic kidney disease (CKD) among adult population of United States (US). Using cross-sectional data from the 2013 to 2018 National Health and Nutrition Examination Survey (NHANES), we explored the association of LAP with CKD, low estimated glomerular filtration rate (eGFR), and albuminuria. This analysis encompassed multivariate logistic regression analyses, smoothed curve fitting, subgroup analyses, and interaction tests. We found a significant positive association between higher ln-transformed LAP (LAP was transformed using a natural logarithm) and the prevalence of CKD, low-eGFR and albuminuria. Notably, this association of ln-transformed LAP with CKD and albuminuria was significantly influenced by diabetes status and sex (P for interaction < 0.05), while no significant interaction was observed regarding the association with low-eGFR (P for interaction > 0.05). Additionally, in model 3 (adjusted for all included covariates except eGFR and urinary albumin-creatinine ratio (UACR)), a nonlinear relationship was identified between ln-transformed LAP and the presence of both CKD and albuminuria, with inflection points of 4.57 and 4.49, respectively. This indicates that this correlation is more pronounced on the right of the inflection point. In conclusion, the findings indicate a significant association between LAP and the prevalence of CKD in US adults.
Identifiants
pubmed: 39271739
doi: 10.1038/s41598-024-71894-2
pii: 10.1038/s41598-024-71894-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21423Subventions
Organisme : Huai'an City Science and Technology Program Project
ID : HAB202211
Organisme : Scientific Research Project from Jiangsu Commission of Health of China
ID : H2019062
Organisme : Project of Science and Technology Development of Affiliated Hospital of Xuzhou Medical University
ID : XYFM202248
Organisme : National Natural Science Foundation of China
ID : 82170757
Informations de copyright
© 2024. The Author(s).
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