Enlightening the toxinological dark matter of spider venom enzymes.
Journal
npj biodiversity
ISSN: 2731-4243
Titre abrégé: NPJ Biodivers
Pays: England
ID NLM: 9918804277406676
Informations de publication
Date de publication:
13 Sep 2024
13 Sep 2024
Historique:
received:
19
04
2024
accepted:
15
08
2024
medline:
14
9
2024
pubmed:
14
9
2024
entrez:
13
9
2024
Statut:
epublish
Résumé
Spiders produce highly adapted venoms featuring a complex mixture of biomolecules used mainly for hunting and defense. The most prominent components are peptidic neurotoxins, a major focus of research and drug development, whereas venom enzymes have been largely neglected. Nevertheless, investigation of venom enzymes not only reveals insights into their biological functions, but also provides templates for future industrial applications. Here we compared spider venom enzymes validated at protein level contained in the VenomZone database and from all publicly available proteo-transcriptomic spider venom datasets. We assigned reported enzymes to cellular processes and known venom functions, including toxicity, prey pre-digestion, venom preservation, venom component activation, and spreading factors. Our study unveiled extensive discrepancy between public databases and publications with regard to enzyme coverage, which impedes the development of novel spider venom enzyme-based applications. Uncovering the previously unrecognized abundance and diversity of venom enzymes will open new avenues for spider venom biodiscovery.
Identifiants
pubmed: 39271930
doi: 10.1038/s44185-024-00058-2
pii: 10.1038/s44185-024-00058-2
doi:
Types de publication
Journal Article
Langues
eng
Pagination
25Subventions
Organisme : Hessisches Ministerium für Wissenschaft und Kunst
ID : LOEWE-TBG
Organisme : Hessisches Ministerium für Wissenschaft und Kunst
ID : LOEWE-TBG
Organisme : Hessisches Ministerium für Wissenschaft und Kunst
ID : LOEWE-TBG
Informations de copyright
© 2024. The Author(s).
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