Rare Clinical Symptoms in Hairy Cell Leukemia: An Overview.

bone lesions cardiac manifestation hairy cell leukemia leukemia cutis neurological manifestations ocular manifestations pulmonary involvement pulmonary symptoms rare symptoms

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
01 Sep 2024
Historique:
received: 08 08 2024
revised: 29 08 2024
accepted: 30 08 2024
medline: 14 9 2024
pubmed: 14 9 2024
entrez: 14 9 2024
Statut: epublish

Résumé

Hairy cell leukemia (HCL) is a rare indolent B-cell lymphoid malignancy. The majority of patients are asymptomatic and HCL is usually diagnosed incidentally during a routine blood cell count. In symptomatic patients, typical symptoms are related to pancytopenia and splenomegaly. In this review, we present rare clinical symptoms in patients with HCL. A literature search was conducted of PubMed, Web of Science and Google Scholar for articles concerning hairy cell leukemia, leukemia cutis, bone lesions, neurological manifestations, pulmonary symptoms, ocular manifestations, cardiac manifestation and rare symptoms. Publications from January 1980 to August 2024 were scrutinized. Additional relevant publications were obtained by reviewing the references from the chosen articles. Extramedullary and extranodal manifestations of classic HCL are rare. However, leukemic involvement in the skin, bone, central nervous system, gastrointestinal tract, heart, kidney, liver, lung, ocular system and other organs have been reported.

Sections du résumé

BACKGROUND BACKGROUND
Hairy cell leukemia (HCL) is a rare indolent B-cell lymphoid malignancy. The majority of patients are asymptomatic and HCL is usually diagnosed incidentally during a routine blood cell count. In symptomatic patients, typical symptoms are related to pancytopenia and splenomegaly. In this review, we present rare clinical symptoms in patients with HCL.
METHODS METHODS
A literature search was conducted of PubMed, Web of Science and Google Scholar for articles concerning hairy cell leukemia, leukemia cutis, bone lesions, neurological manifestations, pulmonary symptoms, ocular manifestations, cardiac manifestation and rare symptoms. Publications from January 1980 to August 2024 were scrutinized. Additional relevant publications were obtained by reviewing the references from the chosen articles.
RESULTS RESULTS
Extramedullary and extranodal manifestations of classic HCL are rare. However, leukemic involvement in the skin, bone, central nervous system, gastrointestinal tract, heart, kidney, liver, lung, ocular system and other organs have been reported.

Identifiants

pubmed: 39272912
pii: cancers16173054
doi: 10.3390/cancers16173054
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Subventions

Organisme : Medical University of Lodz
ID : 503/1-093-01/503-11-004 and 503/1093-1/503-11-003

Auteurs

Tadeusz Robak (T)

Department of Hematology, Medical University of Lodz, 91-738 Lodz, Poland.
Department of General Hematology, Copernicus Memorial Hospital, 93-510 Lodz, Poland.

Marcin Braun (M)

Department of Pathology, Medical University of Lodz, 92-213 Lodz, Poland.

Agnieszka Janus (A)

Department of General Hematology, Copernicus Memorial Hospital, 93-510 Lodz, Poland.

Anna Guminska (A)

Department of Nuclear Medicine, Copernicus Memorial Hospital, 93-513 Lodz, Poland.

Ewa Robak (E)

Department of Dermatology, Medical University of Lodz, 90-647 Lodz, Poland.

Classifications MeSH