Context-Dependent Distinct Roles of SOX9 in Combined Hepatocellular Carcinoma-Cholangiocarcinoma.

SOX9 Transcription Factor / metabolism Carcinoma, Hepatocellular / pathology Liver Neoplasms / pathology Cholangiocarcinoma / pathology Animals Humans Mice Cell Proliferation / genetics
NRAS YAP1 bile duct liver cancer mixed hepatocellular carcinoma–cholangiocarcinoma plasticity trans-differentiation

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
29 Aug 2024
Historique:
received: 21 06 2024
revised: 23 08 2024
accepted: 27 08 2024
medline: 14 9 2024
pubmed: 14 9 2024
entrez: 14 9 2024
Statut: epublish

Résumé

Combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA) is a challenging primary liver cancer subtype with limited treatment options and a devastating prognosis. Recent studies have underscored the context-dependent roles of SOX9 in liver cancer formation in a preventive manner. Here, we revealed that liver-specific developmental

Identifiants

DOI: 10.3390/cells13171451 PMID: 39273023
pubmed: 39273023
pii: cells13171451
doi: 10.3390/cells13171451
pii:
doi:

Substances chimiques

SOX9 Transcription Factor 0
SOX9 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH NCI
ID : R01CA258449

Auteurs

Yoojeong Park (Y)

Division of Experimental Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
ORCID: 0009-0005-1828-7147

Shikai Hu (S)

Division of Experimental Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
School of Medicine, Tsinghua University, Beijing 100084, China.
ORCID: 0000-0002-0817-991X

Minwook Kim (M)

Division of Experimental Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
ORCID: 0000-0002-0093-4562

Michael Oertel (M)

Division of Experimental Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Aatur Singhi (A)

Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Division of Anatomic Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Satdarshan P Monga (SP)

Division of Experimental Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Division of Gastroenterology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
ORCID: 0000-0002-8437-3378

Silvia Liu (S)

Division of Experimental Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
ORCID: 0000-0002-1840-9520

Sungjin Ko (S)

Division of Experimental Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
ORCID: 0000-0002-6079-5939

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription SOX › Facteurs de transcription SOX-E › Facteur de transcription SOX-9 › Context-Dependent Distinct Roles of SOX9 in...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › Context-Dependent Distinct Roles of SOX9 in...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Context-Dependent Distinct Roles of SOX9 in...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Cholangiocarcinome › Context-Dependent Distinct Roles of SOX9 in...
questionsmedicales.fr › Eucaryotes › Animaux › Context-Dependent Distinct Roles of SOX9 in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Context-Dependent Distinct Roles of SOX9 in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Context-Dependent Distinct Roles of SOX9 in...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Context-Dependent Distinct Roles of SOX9 in...