Identification of Novel Independent Correlations between Cellular Components of the Immune System and Strain-Related Indices of Myocardial Dysfunction in CKD Patients and Kidney Transplant Recipients without Established Cardiovascular Disease.

Humans Kidney Transplantation / adverse effects Male Female Renal Insufficiency, Chronic / immunology Middle Aged Monocytes / metabolism Echocardiography Adult Lipopolysaccharide Receptors / metabolism Cardiovascular Diseases / etiology Aged Transplant Recipients Immune System Receptors, IgG / metabolism
CD4+ T-cells CD8+ T-cells CKD cardiac remodeling classical CD14++CD16− monocytes intermediate CD14++CD16+ monocytes kidney transplantation left ventricular strain natural killer cells subclinical myocardial dysfunction

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
23 Aug 2024
Historique:
received: 25 06 2024
revised: 15 08 2024
accepted: 21 08 2024
medline: 14 9 2024
pubmed: 14 9 2024
entrez: 14 9 2024
Statut: epublish

Résumé

The role of immune system components in the development of myocardial remodeling in chronic kidney disease (CKD) and kidney transplantation remains an open question. Our aim was to investigate the associations between immune cell subpopulations in the circulation of CKD patients and kidney transplant recipients (KTRs) with subclinical indices of myocardial performance. We enrolled 44 CKD patients and 38 KTRs without established cardiovascular disease. A selected panel of immune cells was measured by flow cytometry. Classical and novel strain-related indices of ventricular function were measured by speckle-tracking echocardiography at baseline and following dipyridamole infusion. In CKD patients, the left ventricular (LV) relative wall thickness correlated with the CD14++CD16- monocytes (β = 0.447,

Identifiants

DOI: 10.3390/ijms25179162 PMID: 39273110
pubmed: 39273110
pii: ijms25179162
doi: 10.3390/ijms25179162
pii:
doi:

Substances chimiques

Lipopolysaccharide Receptors 0
Receptors, IgG 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Anila Duni (A)

Department of Nephrology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.
Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.

Athanasios Kitsos (A)

Department of Nephrology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.
Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.

Aris Bechlioulis (A)

Second Department of Cardiology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.
ORCID: 0000-0003-1721-2539

Lampros Lakkas (L)

Second Department of Cardiology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.
ORCID: 0000-0001-9401-3125

Georgios Markopoulos (G)

Laboratory of Haematology-Unit of Molecular Biology and Translational Flow Cytometry, University Hospital of Ioannina, 455 00 Ioannina, Greece.
ORCID: 0000-0002-7700-7003

Vasileios Tatsis (V)

Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.

Vasileios Koutlas (V)

Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.
ORCID: 0009-0008-4862-8661

Eirini Tzalavra (E)

Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.

Gerasimos Baxevanos (G)

Laboratory of Haematology-Unit of Molecular Biology and Translational Flow Cytometry, University Hospital of Ioannina, 455 00 Ioannina, Greece.
Department of Internal Medicine, General Hospital of Ioannina, G. Chatzikosta, 454 45 Ioannina, Greece.

Georgios Vartholomatos (G)

Laboratory of Haematology-Unit of Molecular Biology and Translational Flow Cytometry, University Hospital of Ioannina, 455 00 Ioannina, Greece.
ORCID: 0000-0003-3884-4965

Michail Mitsis (M)

Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.

Katerina K Naka (KK)

Second Department of Cardiology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.
ORCID: 0000-0002-9900-9659

Evangelia Dounousi (E)

Department of Nephrology, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.
Kidney Transplant Unit, Department of Surgery, Faculty of Medicine, School of Health Sciences, University Hospital of Ioannina, University of Ioannina, 455 00 Ioannina, Greece.
ORCID: 0000-0002-1172-1829

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of Novel Independent...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie urologique › Transplantation rénale › Identification of Novel Independent...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Identification of Novel Independent...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Identification of Novel Independent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Identification of Novel Independent...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic cardiovasculaire › Tests de la fonction cardiaque › Échocardiographie › Identification of Novel Independent...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Identification of Novel Independent...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des myélomonocytes › Antigènes CD14 › Identification of Novel Independent...
questionsmedicales.fr › Maladies cardiovasculaires › Identification of Novel Independent...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Identification of Novel Independent...
questionsmedicales.fr › Personnes › Receveurs de transplantation › Identification of Novel Independent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Identification of Novel Independent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteur Fc › Récepteurs du fragment Fc des IgG › Identification of Novel Independent...