Lipid Peroxidation Regulators GPX4 and FSP1 as Prognostic Markers and Therapeutic Targets in Advanced Gastric Cancer.

Stomach Neoplasms / metabolism Humans Phospholipid Hydroperoxide Glutathione Peroxidase / metabolism Lipid Peroxidation Prognosis Female Male Biomarkers, Tumor / metabolism Aged Middle Aged Ferroptosis / drug effects Cell Line, Tumor Aldehydes / metabolism Calcium-Binding Proteins / metabolism
chemotherapy ferroptosis gastric cancer lipid peroxidation

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
24 Aug 2024
Historique:
received: 31 07 2024
revised: 20 08 2024
accepted: 22 08 2024
medline: 14 9 2024
pubmed: 14 9 2024
entrez: 14 9 2024
Statut: epublish

Résumé

Gastric cancer is one of the most common cancers worldwide, and new therapeutic strategies are urgently needed. Ferroptosis is an intracellular iron-dependent cell death induced by the accumulation of lipid peroxidation, a mechanism different from conventional apoptosis and necrosis. Therefore, induction of ferroptosis is expected to be a new therapeutic strategy. Glutathione peroxidase 4 (GPX4) and ferroptosis suppressor protein 1 (FSP1) have been identified as the major inhibitors of ferroptosis. Herein, we performed immunohistochemistry for GPX4, FSP1, and 4-HNE using tissues from patients with gastric cancer and investigated the relationship between these factors and prognosis. Patients with high GPX4 expression or high GPX4 expression and low 4-HNE accumulation tended to have a poor prognosis (

Identifiants

DOI: 10.3390/ijms25179203 PMID: 39273151
pubmed: 39273151
pii: ijms25179203
doi: 10.3390/ijms25179203
pii:
doi:

Substances chimiques

Phospholipid Hydroperoxide Glutathione Peroxidase EC 1.11.1.12
Biomarkers, Tumor 0
4-hydroxy-2-nonenal K1CVM13F96
Aldehydes 0
Calcium-Binding Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Kazuhiro Tamura (K)

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Yoshinobu Tomita (Y)

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Takumi Kanazawa (T)

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Department of Clinical Laboratory Medicine, Faculty of Health Science Technology, Bunkyo Gakuin University, Tokyo 113-8668, Japan.

Hajime Shinohara (H)

Department of Gastrointestinal Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Masayoshi Sakano (M)

Department of Gastrointestinal Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Sachiko Ishibashi (S)

Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
ORCID: 0000-0002-6211-0024

Masumi Ikeda (M)

Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
ORCID: 0000-0002-9296-8187

Mayumi Kinoshita (M)

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Department of Clinical Laboratory Medicine, Faculty of Health Science Technology, Bunkyo Gakuin University, Tokyo 113-8668, Japan.
ORCID: 0000-0001-8900-7951

Junko Minami (J)

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Kurara Yamamoto (K)

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
ORCID: 0000-0002-5272-6458

Yuki Kato (Y)

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
ORCID: 0009-0002-4014-2188

Asuka Furukawa (A)

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Shigeo Haruki (S)

Department of Gastrointestinal Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Masanori Tokunaga (M)

Department of Gastrointestinal Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Yusuke Kinugasa (Y)

Department of Gastrointestinal Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
ORCID: 0000-0002-7885-2276

Morito Kurata (M)

Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
ORCID: 0000-0002-1242-6709

Masanobu Kitagawa (M)

Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Kenichi Ohashi (K)

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.

Kouhei Yamamoto (K)

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
ORCID: 0000-0003-3883-4353

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Tumeurs de l'estomac › Lipid Peroxidation Regulators GPX4 and FSP1 as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lipid Peroxidation Regulators GPX4 and FSP1 as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Sélénoprotéines › Glutathione peroxidase › Phospholipid hydroperoxide glutathione peroxidase › Lipid Peroxidation Regulators GPX4 and FSP1 as...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Peroxydation lipidique › Lipid Peroxidation Regulators GPX4 and FSP1 as...
questionsmedicales.fr › Diagnostic › Pronostic › Lipid Peroxidation Regulators GPX4 and FSP1 as...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Lipid Peroxidation Regulators GPX4 and FSP1 as...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Lipid Peroxidation Regulators GPX4 and FSP1 as...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Lipid Peroxidation Regulators GPX4 and FSP1 as...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Ferroptose › Lipid Peroxidation Regulators GPX4 and FSP1 as...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Lipid Peroxidation Regulators GPX4 and FSP1 as...
questionsmedicales.fr › Composés chimiques organiques › Aldéhydes › Lipid Peroxidation Regulators GPX4 and FSP1 as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Lipid Peroxidation Regulators GPX4 and FSP1 as...