Discovery of Aloperine as a Potential Antineoplastic Agent for Cholangiocarcinoma Harboring Mutant IDH1.

Cholangiocarcinoma / drug therapy Humans Isocitrate Dehydrogenase / genetics Bile Duct Neoplasms / drug therapy Cell Line, Tumor Piperidines / pharmacology Antineoplastic Agents / pharmacology Mutation Quinolizidines / pharmacology Cell Proliferation / drug effects
D-2-hydroxyglutarate IDH mutation aloperine intrahepatic cholangiocarcinoma quinolizidine alkaloids

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
25 Aug 2024
Historique:
received: 09 07 2024
revised: 18 08 2024
accepted: 19 08 2024
medline: 14 9 2024
pubmed: 14 9 2024
entrez: 14 9 2024
Statut: epublish

Résumé

Intrahepatic cholangiocarcinoma (ICC) is a universally lethal malignancy with increasing incidence. However, ICC patients receive limited benefits from current drugs; therefore, we must urgently explore new drugs for treating ICC. Quinolizidine alkaloids, as essential active ingredients extracted from

Identifiants

DOI: 10.3390/ijms25179226 PMID: 39273177
pubmed: 39273177
pii: ijms25179226
doi: 10.3390/ijms25179226
pii:
doi:

Substances chimiques

Isocitrate Dehydrogenase EC 1.1.1.41
Piperidines 0
Antineoplastic Agents 0
aloperine 56293-29-9
Quinolizidines 0
IDH1 protein, human EC 1.1.1.42.

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Shanxi Key Laboratory of Redevelopment of Famous Local Traditional Chinese Medicines
ID : 202104010910001
Organisme : Natural Science Funding of Shanxi Province
ID : 202203021221010
Organisme : National Natural Science Foundation of China
ID : 82304319
Organisme : the Program of State Key Laboratory of Quantum Optics and Quantum Optics Devices
ID : KF202106
Organisme : the Traditional Chinese Medicine Innovation Team of Shanxi Province
ID : zyytd2024020
Organisme : the Innovation Team of Shandong Higher School Youth Innovation Technology Program
ID : 2022KJ197

Auteurs

Xingkang Wu (X)

Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.
ORCID: 0000-0001-6480-7952

Yang Li (Y)

Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.

Chenchen Han (C)

Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.

Shifei Li (S)

Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry, Institute of Molecular Science, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.
ORCID: 0000-0003-2112-585X

Xuemei Qin (X)

Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Cholangiocarcinome › Discovery of Aloperine as a Potential...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery of Aloperine as a Potential...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Isocitrate dehydrogenases › Discovery of Aloperine as a Potential...
questionsmedicales.fr › Maladies de l'appareil digestif › Tumeurs de l'appareil digestif › Tumeurs des voies biliaires › Tumeurs des canaux biliaires › Discovery of Aloperine as a Potential...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Discovery of Aloperine as a Potential...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Discovery of Aloperine as a Potential...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Discovery of Aloperine as a Potential...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Discovery of Aloperine as a Potential...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinolizines › Quinolizidines › Discovery of Aloperine as a Potential...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Discovery of Aloperine as a Potential...