Distinct Variations in Gene Expression and Cell Composition across Lichen Planus Subtypes.

Humans Lichen Planus / genetics Female Male Middle Aged Adult Gene Expression Profiling Aged Skin / pathology Transcriptome Gene Expression Regulation Macrophages / metabolism
NanoString immune cell infiltrate lichen planus lichen planus subtypes multiplex immunohistochemistry

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
08 Sep 2024
Historique:
received: 01 08 2024
revised: 30 08 2024
accepted: 04 09 2024
medline: 14 9 2024
pubmed: 14 9 2024
entrez: 14 9 2024
Statut: epublish

Résumé

Lichen planus (LP) is a highly prevalent inflammatory skin disease. While various clinical subtypes have been defined, detailed comparisons of these variants are lacking. This study aimed to elucidate differences in gene expression and cellular composition across LP subtypes. Lesional skin biopsies from 28 LP patients (classical, oral, genital, and lichen planopilaris) and seven non-diseased skin controls (NDC) were analyzed. Gene expression profiling of 730 inflammation-related genes was conducted using NanoString. Immune cell compositions were assessed by multiplex immunohistochemistry. Gene expression profiles revealed unique inflammatory signatures for each LP subtype. Lichen planopilaris exhibited the most divergence, with downregulated gene expression and upregulation of complement pathway genes (

Identifiants

DOI: 10.3390/ijms25179720 PMID: 39273670
pubmed: 39273670
pii: ijms25179720
doi: 10.3390/ijms25179720
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Swiss Life Foundation
ID : 0

Auteurs

Cadri Knoch (C)

Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.

Veronika Baghin (V)

Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.

Patrick Turko (P)

Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
ORCID: 0000-0003-3695-8264

Nicola Winkelbeiner (N)

Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.

Ramon Staeger (R)

Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
ORCID: 0000-0002-9283-9596

Kongchang Wei (K)

Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, Laboratory for Biointerfaces, 9014 St. Gallen, Switzerland.
ORCID: 0000-0002-6555-2768

Irina Banzola (I)

Department of Urology, University Hospital Zurich, 8091 Zurich, Switzerland.
ORCID: 0000-0002-5600-7688

Mark Mellett (M)

Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
ORCID: 0000-0002-6315-167X

Mitchell P Levesque (MP)

Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
ORCID: 0000-0001-5902-9420

Thomas Kuendig (T)

Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
ORCID: 0000-0003-3863-8766

Lars E French (LE)

Department of Dermatology and Allergy, University Hospital, LMU Munich, 80337 Munich, Germany.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Lucie Heinzerling (L)

Department of Dermatology and Allergy, University Hospital, LMU Munich, 80337 Munich, Germany.
Department of Dermatology and Allergy, University Hospital Erlangen, 80337 Erlangen, Germany.

Barbara Meier-Schiesser (B)

Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland.
ORCID: 0000-0003-2807-5066

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Distinct Variations in Gene Expression and...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Éruption lichénoïde › Lichen plan › Distinct Variations in Gene Expression and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Distinct Variations in Gene Expression and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Distinct Variations in Gene Expression and...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Distinct Variations in Gene Expression and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Distinct Variations in Gene Expression and...
questionsmedicales.fr › Système tégumentaire › Peau › Distinct Variations in Gene Expression and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Distinct Variations in Gene Expression and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Distinct Variations in Gene Expression and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Distinct Variations in Gene Expression and...