TSPO Radioligands for Neuroinflammation: An Overview.

Receptors, GABA / metabolism Humans Neuroinflammatory Diseases / metabolism Radiopharmaceuticals / chemistry Animals Ligands Positron-Emission Tomography / methods Brain / metabolism Isoquinolines / chemistry
diagnostic marker neuroinflammation radioligand translocator protein

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
05 Sep 2024
Historique:
received: 29 07 2024
revised: 30 08 2024
accepted: 03 09 2024
medline: 14 9 2024
pubmed: 14 9 2024
entrez: 14 9 2024
Statut: epublish

Résumé

The translocator protein (TSPO) is predominately localized on the outer mitochondrial membrane in steroidogenic cells. In the brain, TSPO expression, low under normal conditions, results upregulated in response to glial cell activation, that occurs in neuroinflammation. As a consequence, TSPO has been extensively studied as a biomarker of such conditions by means of TSPO-targeted radiotracers. Although [

Identifiants

DOI: 10.3390/molecules29174212 PMID: 39275061
pubmed: 39275061
pii: molecules29174212
doi: 10.3390/molecules29174212
pii:
doi:

Substances chimiques

Receptors, GABA 0
TSPO protein, human 0
Radiopharmaceuticals 0
Ligands 0
Isoquinolines 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Italian Ministry of Education, Universities and Research (MIUR) by the funding of "projects of national interest
ID : 2022CF5T454

Auteurs

Silvia Salerno (S)

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
ORCID: 0000-0002-6072-4698

Monica Viviano (M)

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
ORCID: 0000-0003-1118-790X

Emma Baglini (E)

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Valeria Poggetti (V)

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Doralice Giorgini (D)

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.

Jacopo Castagnoli (J)

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.

Elisabetta Barresi (E)

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
ORCID: 0000-0002-9814-7195

Sabrina Castellano (S)

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.

Federico Da Settimo (F)

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
ORCID: 0000-0002-7897-7917

Sabrina Taliani (S)

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
ORCID: 0000-0001-8675-939X

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › TSPO Radioligands for Neuroinflammation: An Overview.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › TSPO Radioligands for Neuroinflammation: An Overview.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Maladies neuro-inflammatoires › TSPO Radioligands for Neuroinflammation: An Overview.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › TSPO Radioligands for Neuroinflammation: An Overview.
questionsmedicales.fr › Eucaryotes › Animaux › TSPO Radioligands for Neuroinflammation: An Overview.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › TSPO Radioligands for Neuroinflammation: An Overview.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › TSPO Radioligands for Neuroinflammation: An Overview.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › TSPO Radioligands for Neuroinflammation: An Overview.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › TSPO Radioligands for Neuroinflammation: An Overview.