The concentration of LEAP2 in human milk and infant plasma is positively associated with adiposity and body weight in the first year of life.
LEAP2
infant adiposity
infant body weight
lactation
milk hormones
Journal
The Journal of nutrition
ISSN: 1541-6100
Titre abrégé: J Nutr
Pays: United States
ID NLM: 0404243
Informations de publication
Date de publication:
12 Sep 2024
12 Sep 2024
Historique:
received:
19
04
2024
revised:
30
08
2024
accepted:
06
09
2024
medline:
15
9
2024
pubmed:
15
9
2024
entrez:
14
9
2024
Statut:
aheadofprint
Résumé
The liver-expressed antimicrobial peptide 2 (LEAP2) is a recently recognized anorectic and glucose-regulating hormone, with unknown role in lactation. 1) Assess LEAP2 presence in human milk and putative associations with infant body weight and adiposity in the first year of life, 2) Evaluate the impact of maternal weight status on LEAP2 concentration and 3) Explore the relationship between infant plasma LEAP2 concentration and body weight and adiposity. This prospective cohort observational study assessed LEAP2 concentration in plasma and milk from lactating women with normal weight (n=26) or overweight/obesity (OW/OB, n=26) at six months postpartum and in 6-month-old infant plasma, examining associations with metabolic and anthropometric variables at 6 months and 1 year. Maternal plasma and milk leptin and insulin concentrations were also measured. LEAP2 expression in milk fat globules and single-cell-RNA-sequencing datasets was evaluated. LEAP2 was detected in all milk samples assessed (2.08±0.65 ng/ml) and was positively associated with infant triceps (p=0.022, Cohen f Milk LEAP2 is a bioactive component that plays a role in infant fat accretion in the first year of life. While maternal LEAP2 responds to weight change in pregnancy and lactation, infant plasma LEAP2 might be involved in body weight regulation in early life. This study was registered at clinicaltrials.gov as NCT05798676. https://clinicaltrials.gov/study/NCT05798676.
Sections du résumé
BACKGROUND
BACKGROUND
The liver-expressed antimicrobial peptide 2 (LEAP2) is a recently recognized anorectic and glucose-regulating hormone, with unknown role in lactation.
OBJECTIVES
OBJECTIVE
1) Assess LEAP2 presence in human milk and putative associations with infant body weight and adiposity in the first year of life, 2) Evaluate the impact of maternal weight status on LEAP2 concentration and 3) Explore the relationship between infant plasma LEAP2 concentration and body weight and adiposity.
METHODS
METHODS
This prospective cohort observational study assessed LEAP2 concentration in plasma and milk from lactating women with normal weight (n=26) or overweight/obesity (OW/OB, n=26) at six months postpartum and in 6-month-old infant plasma, examining associations with metabolic and anthropometric variables at 6 months and 1 year. Maternal plasma and milk leptin and insulin concentrations were also measured. LEAP2 expression in milk fat globules and single-cell-RNA-sequencing datasets was evaluated.
RESULTS
RESULTS
LEAP2 was detected in all milk samples assessed (2.08±0.65 ng/ml) and was positively associated with infant triceps (p=0.022, Cohen f
CONCLUSIONS
CONCLUSIONS
Milk LEAP2 is a bioactive component that plays a role in infant fat accretion in the first year of life. While maternal LEAP2 responds to weight change in pregnancy and lactation, infant plasma LEAP2 might be involved in body weight regulation in early life.
CLINICAL TRIAL REGISTRY
BACKGROUND
This study was registered at clinicaltrials.gov as NCT05798676. https://clinicaltrials.gov/study/NCT05798676.
Identifiants
pubmed: 39277116
pii: S0022-3166(24)01025-3
doi: 10.1016/j.tjnut.2024.09.008
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT05798676']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☐ The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: