Metabolic reprogramming by mutant GNAS creates an actionable dependency in intraductal papillary mucinous neoplasms of the pancreas.
gastric metaplasia
glucose metabolism
oncogenes
pancreatic cancer
pre-malignancy - GI tract
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
13 Sep 2024
13 Sep 2024
Historique:
received:
13
03
2024
accepted:
04
09
2024
medline:
15
9
2024
pubmed:
15
9
2024
entrez:
14
9
2024
Statut:
aheadofprint
Résumé
Oncogenic 'hotspot' mutations of We aim to unveil the consequences of mutant We performed multimodal transcriptional profiling (bulk RNA sequencing, single-cell RNA sequencing and spatial transcriptomics) in the Induction of Multiple orthogonal approaches demonstrate that
Sections du résumé
BACKGROUND
BACKGROUND
Oncogenic 'hotspot' mutations of
OBJECTIVE
OBJECTIVE
We aim to unveil the consequences of mutant
DESIGN
METHODS
We performed multimodal transcriptional profiling (bulk RNA sequencing, single-cell RNA sequencing and spatial transcriptomics) in the
RESULTS
RESULTS
Induction of
CONCLUSION
CONCLUSIONS
Multiple orthogonal approaches demonstrate that
Identifiants
pubmed: 39277181
pii: gutjnl-2024-332412
doi: 10.1136/gutjnl-2024-332412
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: AM is listed as an inventor on a patent that has been licensed by Johns Hopkins University to Thrive Earlier Detection. AM serves as a consultant for Tezcat Biosciences.