Precision Medicine in Bariatric Procedures.

Humans Precision Medicine / methods Bariatric Surgery / methods Obesity / surgery Genomics / methods
Bariatric endoscopy Bariatric surgery Epigenetics Genetics Obesity Precision medicine

Journal

Gastrointestinal endoscopy clinics of North America
ISSN: 1558-1950
Titre abrégé: Gastrointest Endosc Clin N Am
Pays: United States
ID NLM: 9202792

Informations de publication

Date de publication:
Oct 2024
Historique:
medline: 15 9 2024
pubmed: 15 9 2024
entrez: 14 9 2024
Statut: ppublish

Résumé

Obesity is a multi-factorial disease that is influenced by genetic, epigenetic, and environmental factors. Precision medicine is a practice wherein prevention and treatment strategies take individual variability into account. It involves using a variety of factors including deep phenotyping using clinical, physiologic, and behavioral characteristics, 'omics assays (eg, genomics, epigenomics, transcriptomics, and microbiomics among others), and environmental factors to devise practices that are individualized to subsets of patients. Personalizing the therapeutic modality to the individual can lead to enhanced effectiveness and tolerability. The authors review advances in precision medicine made in the field of bariatrics and discuss future avenues and challenges.

Identifiants

DOI: 10.1016/j.giec.2024.03.004 PMID: 39277304
pubmed: 39277304
pii: S1052-5157(24)00026-6
doi: 10.1016/j.giec.2024.03.004
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

765-779

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosures A. Acosta and Mayo Clinic hold equity in Phenomix Sciences Inc. and are inventors of intellectual property licensed to Phenomix Sciences Inc. A. Acosta served as a consultant for Rhythm Pharmaceuticals, General Mills, Amgen, Bausch Health, RareStone; has contracts with Vivus Inc, Satiogen Pharmaceutical, and Rhythm pharmaceutical. The remaining authors have nothing to disclose.

Auteurs

Khushboo Gala (K)

Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55902, USA. Electronic address: https://twitter.com/KhushbooSGala.

Wissam Ghusn (W)

Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55902, USA; Department of Internal Medicine, Boston University Medical Center, Harrison Avenue, Boston, MA 02111, USA. Electronic address: https://twitter.com/Wissam_Ghusn.

Andres Acosta (A)

Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55902, USA. Electronic address: acosta.andres@mayo.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Precision Medicine in Bariatric Procedures.
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Precision Medicine in Bariatric Procedures.
questionsmedicales.fr › Procédures de chirurgie opératoire › Chirurgie bariatrique › Precision Medicine in Bariatric Procedures.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Precision Medicine in Bariatric Procedures.
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Precision Medicine in Bariatric Procedures.