Harnessing glycofluoroforms for impedimetric biosensing.


Journal

Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951

Informations de publication

Date de publication:
13 Sep 2024
Historique:
received: 03 07 2024
accepted: 04 09 2024
medline: 17 9 2024
pubmed: 17 9 2024
entrez: 16 9 2024
Statut: aheadofprint

Résumé

Glycans play a major role in biological cell-cell recognition and signal transduction but have found limited application in biosensors due to glycan/lectin promiscuity; multiple proteins are capable of binding to the same native glycan. Here, site-specific fluorination is used to introduce protein-glycan selectivity, and this is coupled with an electrochemical detection method to generate a novel biosensor platform. 3F-lacto-

Identifiants

pubmed: 39282644
doi: 10.1039/d4sc04409f
pii: d4sc04409f
pmc: PMC11393611
doi:

Types de publication

Journal Article

Langues

eng

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

Auteurs

Alice R Hewson (AR)

Department of Chemistry, University of York YO10 5DD York UK alison.parkin@york.ac.uk martin.fascione@york.ac.uk.

Henry O Lloyd-Laney (HO)

Department of Chemistry, University of York YO10 5DD York UK alison.parkin@york.ac.uk martin.fascione@york.ac.uk.

Tessa Keenan (T)

Department of Chemistry, University of York YO10 5DD York UK alison.parkin@york.ac.uk martin.fascione@york.ac.uk.

Sarah-Jane Richards (SJ)

Department of Chemistry, The University of Manchester M13 9PL UK.
Manchester Institute of Biotechnology, The University of Manchester M1 7DN UK.

Matthew I Gibson (MI)

Department of Chemistry, The University of Manchester M13 9PL UK.
Manchester Institute of Biotechnology, The University of Manchester M1 7DN UK.

Bruno Linclau (B)

Department of Organic and Macromolecular Chemistry, Ghent University Krijgslaan 281-S4 9000 Gent Belgium.
School of Chemistry, University of Southampton Highfield Southampton SO17 1BJ UK.

Nathalie Signoret (N)

Hull York Medical School, University of York YO10 5DD York UK.

Martin A Fascione (MA)

Department of Chemistry, University of York YO10 5DD York UK alison.parkin@york.ac.uk martin.fascione@york.ac.uk.

Alison Parkin (A)

Department of Chemistry, University of York YO10 5DD York UK alison.parkin@york.ac.uk martin.fascione@york.ac.uk.

Classifications MeSH