Cerebral, Splanchnic, and Renal Transit Time Measurement and Blood Volume Estimation Using Contrast-Enhanced Ultrasonography.
Humans
Female
Male
Adult
Ultrasonography
/ methods
Contrast Media
Blood Volume
/ physiology
Splanchnic Circulation
/ physiology
Kidney
/ diagnostic imaging
Cerebrovascular Circulation
/ physiology
Blood Flow Velocity
/ physiology
Brain
/ diagnostic imaging
Middle Aged
Reproducibility of Results
Image Enhancement
/ methods
Blood Volume Determination
/ methods
Renal Circulation
/ physiology
Journal
Ultrasound quarterly
ISSN: 1536-0253
Titre abrégé: Ultrasound Q
Pays: United States
ID NLM: 8809459
Informations de publication
Date de publication:
01 Dec 2024
01 Dec 2024
Historique:
medline:
17
9
2024
pubmed:
17
9
2024
entrez:
16
9
2024
Statut:
epublish
Résumé
We aimed to measure cerebral, splanchnic, and renal transit times and the associated blood volumes using contrast ultrasound. In healthy individuals, regional transit times were calculated from time-intensity curves generated as ultrasound contrast passed through the associated inflow and outflow vessels. These included the internal carotid artery and internal jugular vein (brain), the superior mesenteric artery and portal vein (intestines), and the renal artery and renal vein (kidney). An organ's blood volume relative to the stroke volume delivered to that organ with each cardiac cycle was calculated from the product of heart rate and transit time of contrast passage through the associated vascular bed. The fraction of systemic stroke volume received by each organ was calculated from the respective velocity-time integral and inflow vessel cross-sectional area and used to estimate absolute organ blood volume. The cohort consisted of 16 participants (age: 42 ± 13 years; 5 female) without known cerebrovascular, gastrointestinal, or renal disease. Cerebral, splanchnic, and renal transit times were obtained for 15, 14, and 8 individuals, respectively. Anatomic variability of the renal vessels confounded the acquisition of renal transit times. For all organs, transit times were reproducible and the associated blood volumes were generally comparable to reference values. Cerebral, gastrointestinal, and renal transit times/blood volumes can be reasonably acquired from contrast ultrasound, although the latter is less reliably available. Assessment of the impact on regional blood volumes of pharmacologic or other interventions is a next step toward clinical application of this technique.
Identifiants
pubmed: 39282951
doi: 10.1097/RUQ.0000000000000687
pii: 00013644-202412000-00002
pii:
doi:
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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