Lifestyle interventions in cardiometabolic HFpEF: dietary and exercise modalities.

Diet Exercise HFpEF Obesity

Journal

Heart failure reviews
ISSN: 1573-7322
Titre abrégé: Heart Fail Rev
Pays: United States
ID NLM: 9612481

Informations de publication

Date de publication:
16 Sep 2024
Historique:
accepted: 05 09 2024
medline: 17 9 2024
pubmed: 17 9 2024
entrez: 16 9 2024
Statut: aheadofprint

Résumé

Heart failure with preserved ejection fraction (HFpEF) is rapidly growing as the most common form of heart failure. Among HFpEF phenotypes, the cardiometabolic/obese HFpEF - HFpEF driven by cardiometabolic alterations - emerges as one of the most prevalent forms of this syndrome and the one on which recent therapeutic success have been made. Indeed, pharmacological approaches with sodium-glucose cotransporter type 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) have proved to be effective due to metabolic protective effects. Similarly, lifestyle changes, including diet and exercise are crucial in HFpEF management. Increasing evidence supports the important role of diet and physical activity in the pathogenesis, prognosis, and potential reversal of HFpEF. Metabolic derangements and systemic inflammation are key features of HFpEF and represent the main targets of lifestyle interventions. However, the underlying mechanisms of the beneficial effects of these interventions in HFpEF are incompletely understood. Hence, there is an unmet need of tailored lifestyle intervention modalities for patients with HFpEF. Here we present the current available evidence on lifestyle interventions in HFpEF management and therapeutics, discussing their modalities and potential mechanisms.

Identifiants

pubmed: 39283525
doi: 10.1007/s10741-024-10439-1
pii: 10.1007/s10741-024-10439-1
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Antonio Vacca (A)

Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Clinica Medica, Department of Medicine, University of Udine, Udine, Italy.

Rongling Wang (R)

Deutsches Herzzentrum Der Charité (DHZC), Charité-Universitätsmedizin Berlin, Berlin, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

Natasha Nambiar (N)

Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

Federico Capone (F)

Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Division of Internal Medicine, Department of Medicine-DIMED, University of Padua, Padua, Italy.

Catherine Farrelly (C)

Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

Ahmed Mostafa (A)

Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

Leonardo A Sechi (LA)

Clinica Medica, Department of Medicine, University of Udine, Udine, Italy.

Gabriele G Schiattarella (GG)

Deutsches Herzzentrum Der Charité (DHZC), Charité-Universitätsmedizin Berlin, Berlin, Germany. gabriele.schiattarella@dhzc-charite.de.
DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany. gabriele.schiattarella@dhzc-charite.de.
Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. gabriele.schiattarella@dhzc-charite.de.
Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy. gabriele.schiattarella@dhzc-charite.de.

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