Lipoprotein metabolism mediates hematopoietic stem cell responses under acute anemic conditions.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
16 Sep 2024
Historique:
received: 05 12 2022
accepted: 06 09 2024
medline: 17 9 2024
pubmed: 17 9 2024
entrez: 16 9 2024
Statut: epublish

Résumé

Hematopoietic stem cells (HSCs) react to various stress conditions. However, it is unclear whether and how HSCs respond to severe anemia. Here, we demonstrate that upon induction of acute anemia, HSCs rapidly proliferate and enhance their erythroid differentiation potential. In severe anemia, lipoprotein profiles largely change and the concentration of ApoE increases. In HSCs, transcription levels of lipid metabolism-related genes, such as very low-density lipoprotein receptor (Vldlr), are upregulated. Stimulation of HSCs with ApoE enhances their erythroid potential, whereas HSCs in Apoe knockout mice do not respond to anemia induction. Vldlr

Identifiants

pubmed: 39284836
doi: 10.1038/s41467-024-52509-w
pii: 10.1038/s41467-024-52509-w
doi:

Substances chimiques

Apolipoproteins E 0
Lipoproteins 0
Receptors, LDL 0
Chromatin 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8131

Informations de copyright

© 2024. The Author(s).

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Auteurs

Kiyoka Saito (K)

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.

Mark van der Garde (M)

Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.
Department of Medicine III, Hematology and Oncology, Technical University of Munich, Munich, Germany.

Terumasa Umemoto (T)

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

Natsumi Miharada (N)

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

Julia Sjöberg (J)

Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.

Valgardur Sigurdsson (V)

Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.

Haruki Shirozu (H)

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

Shunsuke Kamei (S)

Division of Molecular and Vascular Biology, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan.

Visnja Radulovic (V)

Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.

Mitsuyoshi Suzuki (M)

Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.
Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.

Satoshi Nakano (S)

Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.
Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.

Stefan Lang (S)

StemTherapy Bioinformatics Core facility, Lund Stem Cell Center, Lund University, Lund, Sweden.

Jenny Hansson (J)

Division of Molecular Hematology, Lund Stem Cell Center, Lund University, Lund, Sweden.

Martin L Olsson (ML)

Division of Hematology and Transfusion Medicine, Lund University, Lund, Sweden.

Takashi Minami (T)

Division of Molecular and Vascular Biology, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan.

Gunnar Gouras (G)

Department of Experimental Medical Sciences, Lund University, Lund, Sweden.

Johan Flygare (J)

Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden.

Kenichi Miharada (K)

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan. kenmiharada@kumamoto-u.ac.jp.
Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden. kenmiharada@kumamoto-u.ac.jp.

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