Prevalence and macrolide resistance of Mycoplasma genitalium from patients seeking sexual health care in Southern Ghana.
Mycoplasma genitalium
/ drug effects
Humans
Mycoplasma Infections
/ epidemiology
Ghana
/ epidemiology
Female
Male
Adult
Retrospective Studies
Prevalence
Macrolides
/ pharmacology
Anti-Bacterial Agents
/ pharmacology
Drug Resistance, Bacterial
/ genetics
Young Adult
Adolescent
Middle Aged
Sexual Health
Azithromycin
/ pharmacology
Mutation
Microbial Sensitivity Tests
Macrolide resistance
Mycoplasma genitalium
Nucleic Acid Amplification Test (NAAT)
Prevalence
Sexually Transmitted Infections (STI)
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
16 Sep 2024
16 Sep 2024
Historique:
received:
20
05
2024
accepted:
04
09
2024
medline:
17
9
2024
pubmed:
17
9
2024
entrez:
16
9
2024
Statut:
epublish
Résumé
Mycoplasma genitalium (MG), a sexually transmitted infection (STI), has emerged as a common cause of non-gonococcal urethritis and cervicitis worldwide, with documented resistance to commonly used antibiotics including doxycycline and azithromycin. Data in Ghana regarding the prevalence of MG is limited. This retrospective study investigated MG presence and macrolide resistance among patients who previously reported to selected clinics for STI symptoms between December 2012 and June 2020. Samples were screened for MG and mutations associated with azithromycin resistance were investigated using Nucleic Acid Amplification Testing (NAAT) including the Resistance Plus MG A total of 1,015 samples were screened, out of which MG infection rate by TIB Molbiol and SpeeDx were 3.1% and 3.4%, respectively. The mutation responsible for macrolide resistance was detected in one MG positive sample by both assays. Both diagnostic tests revealed no significant association between MG infection and socio-demographic characteristics, clinical symptoms, gonorrhea, and chlamydia infection status. There was no significant difference in the mycoplasma percentage positivity rate detected using SpeeDx (3.4%) and TIB Molbiol (3.1%). While not commonly tested as a cause of STI symptoms, MG is widespread in Ghana, exhibiting symptoms and prevalence comparable to those in other countries and linked to antimicrobial resistance. Future research using various molecular techniques is essential to monitor resistance trends and guide future antibiotic choices.
Sections du résumé
BACKGROUND
BACKGROUND
Mycoplasma genitalium (MG), a sexually transmitted infection (STI), has emerged as a common cause of non-gonococcal urethritis and cervicitis worldwide, with documented resistance to commonly used antibiotics including doxycycline and azithromycin. Data in Ghana regarding the prevalence of MG is limited.
METHODS
METHODS
This retrospective study investigated MG presence and macrolide resistance among patients who previously reported to selected clinics for STI symptoms between December 2012 and June 2020. Samples were screened for MG and mutations associated with azithromycin resistance were investigated using Nucleic Acid Amplification Testing (NAAT) including the Resistance Plus MG
RESULTS
RESULTS
A total of 1,015 samples were screened, out of which MG infection rate by TIB Molbiol and SpeeDx were 3.1% and 3.4%, respectively. The mutation responsible for macrolide resistance was detected in one MG positive sample by both assays. Both diagnostic tests revealed no significant association between MG infection and socio-demographic characteristics, clinical symptoms, gonorrhea, and chlamydia infection status. There was no significant difference in the mycoplasma percentage positivity rate detected using SpeeDx (3.4%) and TIB Molbiol (3.1%).
CONCLUSIONS
CONCLUSIONS
While not commonly tested as a cause of STI symptoms, MG is widespread in Ghana, exhibiting symptoms and prevalence comparable to those in other countries and linked to antimicrobial resistance. Future research using various molecular techniques is essential to monitor resistance trends and guide future antibiotic choices.
Identifiants
pubmed: 39285366
doi: 10.1186/s12879-024-09880-2
pii: 10.1186/s12879-024-09880-2
doi:
Substances chimiques
Macrolides
0
Anti-Bacterial Agents
0
Azithromycin
83905-01-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
981Subventions
Organisme : Global Emerging Infections Surveillance (GEIS)
ID : ProMIS ID P115_21_N3
Organisme : Global Emerging Infections Surveillance (GEIS)
ID : ProMIS ID P115_21_N3
Organisme : Global Emerging Infections Surveillance (GEIS)
ID : ProMIS ID P115_21_N3
Organisme : Global Emerging Infections Surveillance (GEIS)
ID : ProMIS ID P115_21_N3
Organisme : Global Emerging Infections Surveillance (GEIS)
ID : ProMIS ID P115_21_N3
Organisme : Global Emerging Infections Surveillance (GEIS)
ID : ProMIS ID P115_21_N3
Organisme : Global Emerging Infections Surveillance (GEIS)
ID : ProMIS ID P115_21_N3
Organisme : Global Emerging Infections Surveillance (GEIS)
ID : ProMIS ID P115_21_N3
Organisme : Global Emerging Infections Surveillance (GEIS)
ID : ProMIS ID P115_21_N3
Organisme : Global Emerging Infections Surveillance (GEIS)
ID : ProMIS ID P115_21_N3
Informations de copyright
© 2024. The Author(s).
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