Anti-neurodegenerative activity Bis-chalcones Claisen-Schmidt reaction Cytotoxicity Molecular docking

Journal

Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560

Informations de publication

Date de publication:
15 Sep 2024
Historique:
received: 17 06 2024
revised: 27 08 2024
accepted: 28 08 2024
medline: 17 9 2024
pubmed: 17 9 2024
entrez: 17 9 2024
Statut: epublish

Résumé

In the area of research on neurodegenerative diseases, the current challenge is to search for appropriate research methods that would detect these diseases at the earliest possible stage, but also new active structures that would reduce the rate of the disease progression and minimize the intensity of their symptoms experienced by the patient. The chalcones are considered in the context of candidates for new drugs dedicated to the fight against neurodegenerative diseases. The synthesis of

Identifiants

pubmed: 39286165
doi: 10.1016/j.heliyon.2024.e37147
pii: S2405-8440(24)13178-7
pmc: PMC11403034
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e37147

Informations de copyright

© 2024 The Authors.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Dorota Olender (D)

Chair and Department of Organic Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806, Poznań, Poland.

Jacek Kujawski (J)

Chair and Department of Organic Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806, Poznań, Poland.

Bartosz Skóra (B)

Department of Biotechnology and Cell Biology, Medical College, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225, Rzeszów, Poland.

Ewa Baranowska-Wójcik (E)

Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Skromna 8, 20-704, Lublin, Poland.

Katarzyna Sowa-Kasprzak (K)

Chair and Department of Organic Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806, Poznań, Poland.

Anna Pawełczyk (A)

Chair and Department of Organic Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806, Poznań, Poland.

Lucjusz Zaprutko (L)

Chair and Department of Organic Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806, Poznań, Poland.

Dominik Szwajgier (D)

Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Skromna 8, 20-704, Lublin, Poland.

Konrad A Szychowski (KA)

Department of Biotechnology and Cell Biology, Medical College, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225, Rzeszów, Poland.

Classifications MeSH