Novel alloxazine analogues: design, synthesis, and antitumour efficacy enhanced by kinase screening, molecular docking, and ADME studies.

Humans Antineoplastic Agents / pharmacology Structure-Activity Relationship Drug Design Molecular Docking Simulation Drug Screening Assays, Antitumor Molecular Structure Cell Proliferation / drug effects Dose-Response Relationship, Drug Protein Kinase Inhibitors / pharmacology Cell Line, Tumor Flavins
ADME Alloxazine antitumor kinase profiling molecular docking

Journal

Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203

Informations de publication

Date de publication:
Dec 2024
Historique:
medline: 17 9 2024
pubmed: 17 9 2024
entrez: 17 9 2024
Statut: ppublish

Résumé

This study describes the development of novel alloxazine analogues as potent antitumor agents with enhanced selectivity for tumour cells. Twenty-nine out of 45 newly compounds were investigated

Identifiants

DOI: 10.1080/14756366.2024.2398551 PMID: 39287132
pubmed: 39287132
doi: 10.1080/14756366.2024.2398551
doi:

Substances chimiques

Antineoplastic Agents 0
isoalloxazine 490-59-5
Protein Kinase Inhibitors 0
Flavins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2398551

Auteurs

Doaa Samaha (D)

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Egypt.
Institute of Chemistry, Humboldt-Universität zu Berlin, Berlin, Germany.

Sawsan Mahmoud (S)

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Egypt.

Mosaad Sayed Mohamed (MS)

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Egypt.

Rokaia S Abdullah (RS)

Environment Division, National Institute of Oceanography and Fisheries (NIOF), Alexandria, Egypt.
Department of Pharmaceutical Sciences, Irma Lerma Rangel School of Pharmacy, Texas A&M University, College Station, TX, USA.

Nageh A Abou Taleb (N)

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Egypt.

Tomohisa Nagamatsu (T)

Laboratory of Curative Creation Study for Geriatric-diseases Prevention, Faculty of Pharmacological Sciences, Sojo University, Kumamoto, Japan.

Hamed I Ali (HI)

Department of Pharmaceutical Sciences, Irma Lerma Rangel School of Pharmacy, Texas A&M University, College Station, TX, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel alloxazine analogues: design, synthesis,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Novel alloxazine analogues: design, synthesis,...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Novel alloxazine analogues: design, synthesis,...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Novel alloxazine analogues: design, synthesis,...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Novel alloxazine analogues: design, synthesis,...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Novel alloxazine analogues: design, synthesis,...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Novel alloxazine analogues: design, synthesis,...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Novel alloxazine analogues: design, synthesis,...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Novel alloxazine analogues: design, synthesis,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Novel alloxazine analogues: design, synthesis,...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Novel alloxazine analogues: design, synthesis,...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Flavines › Novel alloxazine analogues: design, synthesis,...