Executive Functions are Independently Associated with Cognitive Dispersion in HIV Disease.
Cognitive flexibility
Infectious disease
Neuropsychological assessment
Psychometric
Within-subject variation
Journal
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
ISSN: 1873-5843
Titre abrégé: Arch Clin Neuropsychol
Pays: United States
ID NLM: 9004255
Informations de publication
Date de publication:
17 Sep 2024
17 Sep 2024
Historique:
received:
05
07
2024
revised:
26
08
2024
accepted:
29
08
2024
medline:
17
9
2024
pubmed:
17
9
2024
entrez:
17
9
2024
Statut:
aheadofprint
Résumé
People with HIV (PWH) can demonstrate elevated cognitive intraindividual variability (IIV-dispersion) that is associated with everyday functioning problems. Higher IIV-dispersion is theorized to reflect lapses in executive aspects of cognitive control, but few studies have directly evaluated this possibility. 72 PWH completed the Cogstate and clinical measures of executive functions, psychomotor speed, and episodic memory. IIV-dispersion was calculated with the coefficient of variation (CoV) from six age-adjusted Cogstate subtest scores. Multiple regression showed that the three domain-level cognitive predictors explained 8% of the variance in Cogstate CoV (p = .03). Within this model, poorer executive functions were moderately associated with higher Cogstate CoV (p = .01), but the psychomotor and episodic memory domains were not (ps > .05). Findings align with cognitive theory in demonstrating IIV-dispersion is uniquely associated with independent measures of executive functions among PWH. Future experimental and mechanistic studies are needed to determine the precise executive aspects of IIV-dispersion.
Identifiants
pubmed: 39287143
pii: 7759102
doi: 10.1093/arclin/acae073
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01-MH073419
Pays : United States
Organisme : National Institute on Aging (NIA) of the National Institutes of Health
ID : U54AG063546
Organisme : NIA Imbedded Pragmatic Alzheimer's and ADRelated Dementias Clinical Trials Collaboratory
Informations de copyright
© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.