Mitochondrial Health Markers and Obesity-Related Health in Human Population Studies: A Narrative Review of Recent Literature.
Adiposity
Bariatric Surgery
Epidemiology
Mitochondrial Biomarkers
Mitochondrial DNA
Obesity
Journal
Current obesity reports
ISSN: 2162-4968
Titre abrégé: Curr Obes Rep
Pays: United States
ID NLM: 101578283
Informations de publication
Date de publication:
17 Sep 2024
17 Sep 2024
Historique:
accepted:
29
08
2024
medline:
17
9
2024
pubmed:
17
9
2024
entrez:
17
9
2024
Statut:
aheadofprint
Résumé
This narrative review summarizes current literature on the relationship of mitochondrial biomarkers with obesity-related characteristics, including body mass index and body composition. Mitochondria, as cellular powerhouses, play a pivotal role in energy production and the regulation of metabolic process. Altered mitochondrial functions contribute to obesity, yet evidence of the intricate relationship between mitochondrial dynamics and obesity-related outcomes in human population studies is scarce and warrants further attention. We discuss emerging evidence linking obesity and related health outcomes to impaired oxidative phosphorylation pathways, oxidative stress and mtDNA variants, copy number and methylation, all hallmark of suboptimal mitochondrial function. We also explore the influence of dietary interventions and metabolic and bariatric surgery procedures on restoring mitochondrial attributes of individuals with obesity. Finally, we report on the potential knowledge gaps in the mitochondrial dynamics for human health for future study.
Identifiants
pubmed: 39287712
doi: 10.1007/s13679-024-00588-7
pii: 10.1007/s13679-024-00588-7
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Agha M, Agha R. The rising prevalence of obesity: part A: impact on public health. IJS Oncol. 2017;2: e17. https://doi.org/10.1097/IJ9.0000000000000017 .
Bluher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15:288–9. https://doi.org/10.1038/s41574-019-0176-8 .
pubmed: 30814686
Sanyaolu A, Okorie C, Qi X, Locke J, Rehman S. Childhood and Adolescent Obesity in the United States: A Public Health Concern. Glob Pediatr Health 2019;6:2333794X19891305. https://doi.org/10.1177/2333794X19891305 .
Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL. Trends in Obesity Among Adults in the United States, 2005 to 2014. JAMA. 2016;315:2284–91. https://doi.org/10.1001/jama.2016.6458 .
pubmed: 27272580
pmcid: 11197437
Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of Childhood and Adult Obesity in the United States, 2011–2012. JAMA. 2014;311:806–14. https://doi.org/10.1001/jama.2014.732 .
pubmed: 24570244
pmcid: 4770258
Hales CM, Fryar CD, Carroll MD, Freedman DS, Ogden CL. Trends in Obesity and Severe Obesity Prevalence in US Youth and Adults by Sex and Age, 2007–2008 to 2015–2016. JAMA. 2018;319:1723–5. https://doi.org/10.1001/jama.2018.3060 .
pubmed: 29570750
pmcid: 5876828
Abdelaal M, le Roux CW, Docherty NG. Morbidity and mortality associated with obesity. Ann Transl Med 2017;5:161. https://doi.org/10.21037/atm.2017.03.107 .
Flegal KM, Williamson DF, Pamuk ER, Rosenberg HM. Estimating Deaths Attributable to Obesity in the United States. Am J Public Health. 2004;94:1486–9.
pubmed: 15333299
pmcid: 1448478
World Health Organization. Obesity and overweight. Obes Overweight - Fact Sheets 2021. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (accessed March 30, 2023).
World Obesity Federation. The World Obesity Atlas 2023. https://www.worldobesityday.org/policy-makers (accessed February 14, 2023).
Restrepo BJ. Obesity Prevalence Among U.S. Adults During the COVID-19 Pandemic. Am J Prev Med. 2022;63:102–6. https://doi.org/10.1016/j.amepre.2022.01.012 .
pubmed: 35725124
pmcid: 8977388
Spiegelman BM, Flier JS. Obesity and the Regulation of Energy Balance. Cell. 2001;104:531–43. https://doi.org/10.1016/S0092-8674(01)00240-9 .
pubmed: 11239410
de Ferranti S, Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem. 2008;54:945–55. https://doi.org/10.1373/clinchem.2007.100156 .
pubmed: 18436717
Brand MD, Orr AL, Perevoshchikova IV, Quinlan CL. The role of mitochondrial function and cellular bioenergetics in ageing and disease. Br J Dermatol. 2013;169:1–8. https://doi.org/10.1111/bjd.12208 .
pubmed: 23786614
pmcid: 4321783
Bornstein R, Gonzalez B, Johnson SC. Mitochondrial pathways in human health and aging. Mitochondrion. 2020;54:72–84. https://doi.org/10.1016/j.mito.2020.07.007 .
pubmed: 32738358
pmcid: 7508824
Heinonen S, Buzkova J, Muniandy M, Kaksonen R, Ollikainen M, Ismail K, et al. Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity. Diabetes. 2015;64:3135–45. https://doi.org/10.2337/db14-1937 .
pubmed: 25972572
Lindinger A, Peterli R, Peters T, Kern B, von Flüe M, Calame M, et al. Mitochondrial DNA content in human omental adipose tissue. Obes Surg. 2010;20:84–92. https://doi.org/10.1007/s11695-009-9987-3 .
pubmed: 19826890
Rautenberg EK, Hamzaoui Y, Coletta DK. Mini-review: Mitochondrial DNA methylation in type 2 diabetes and obesity. Front Endocrinol. 2022;13: 968268. https://doi.org/10.3389/fendo.2022.968268 .
Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr. 2000;72:694–701. https://doi.org/10.1093/ajcn/72.3.694 .
pubmed: 10966886
Lemos T, Gallagher D. Current body composition measurement techniques. Curr Opin Endocrinol Diabetes Obes. 2017;24:310–4. https://doi.org/10.1097/MED.0000000000000360 .
pubmed: 28696961
pmcid: 5771660
Gallagher D, Andres A, Fields DA, Evans WJ, Kuczmarski R, Lowe WL, et al. Body Composition Measurements from Birth through 5 Years: Challenges, Gaps, and Existing & Emerging Technologies—A National Institutes of Health workshop. Obes Rev Off J Int Assoc Study Obes. 2020;21: e13033. https://doi.org/10.1111/obr.13033 .
Cypess AM. Reassessing Human Adipose Tissue. N Engl J Med. 2022;386:768–79. https://doi.org/10.1056/NEJMra2032804 .
pubmed: 35196429
Gallagher D, Kuznia P, Heshka S, Albu J, Heymsfield SB, Goodpaster B, et al. Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue. Am J Clin Nutr. 2005;81:903–10.
pubmed: 15817870
Yim J-E, Heshka S, Albu JB, Heymsfield S, Gallagher D. Femoral-gluteal subcutaneous and intermuscular adipose tissues have independent and opposing relationships with CVD risk. J Appl Physiol. 2008;104:700–7. https://doi.org/10.1152/japplphysiol.01035.2007 .
pubmed: 18079271
Gallagher D, Kelley DE, Yim J-E, Spence N, Albu J, Boxt L, et al. Adipose tissue distribution is different in type 2 diabetes2. Am J Clin Nutr. 2009;89:807–14. https://doi.org/10.3945/ajcn.2008.26955 .
pubmed: 19158213
pmcid: 2714397
Zwick RK, Guerrero-Juarez CF, Horsley V, Plikus MV. Anatomical, Physiological, and Functional Diversity of Adipose Tissue. Cell Metab. 2018;27:68–83. https://doi.org/10.1016/j.cmet.2017.12.002 .
pubmed: 29320711
pmcid: 6050204
Gallagher D, Heshka S, Kelley DE, Thornton J, Boxt L, Pi-Sunyer FX, et al. Changes in Adipose Tissue Depots and Metabolic Markers Following a 1-Year Diet and Exercise Intervention in Overweight and Obese Patients With Type 2 Diabetes. Diabetes Care. 2014;37:3325–32. https://doi.org/10.2337/dc14-1585 .
pubmed: 25336745
pmcid: 4237982
Toro-Ramos T, Goodpaster BH, Janumala I, Lin S, Strain GW, Thornton JC, et al. Continued Loss in Visceral and Intermuscular Adipose Tissue in Weight-Stable Women Following Bariatric Surgery. Obes Silver Spring Md. 2015;23:62–9. https://doi.org/10.1002/oby.20932 .
Saely CH, Geiger K, Drexel H. Brown versus white adipose tissue: a mini-review. Gerontology. 2012;58:15–23. https://doi.org/10.1159/000321319 .
pubmed: 21135534
Zhu Q, An YA, Scherer PE. Mitochondrial regulation and white adipose tissue homeostasis. Trends Cell Biol. 2022;32:351–64. https://doi.org/10.1016/j.tcb.2021.10.008 .
pubmed: 34810062
Giralt M, Villarroya F. White, Brown, Beige/Brite: Different Adipose Cells for Different Functions? Endocrinology. 2013;154:2992–3000. https://doi.org/10.1210/en.2013-1403 .
pubmed: 23782940
Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al. Identification and Importance of Brown Adipose Tissue in Adult Humans. N Engl J Med. 2009;360:1509–17. https://doi.org/10.1056/NEJMoa0810780 .
pubmed: 19357406
pmcid: 2859951
Pfannenberg C, Werner MK, Ripkens S, Stef I, Deckert A, Schmadl M, et al. Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans. Diabetes. 2010;59:1789–93. https://doi.org/10.2337/db10-0004 .
pubmed: 20357363
pmcid: 2889780
Abernathy RP, Black DR. Healthy body weights: an alternative perspective. Am J Clin Nutr. 1996;63:448S-451S. https://doi.org/10.1093/ajcn/63.3.448 .
pubmed: 8615340
Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders. Front Endocrinol. 2016;7:30. https://doi.org/10.3389/fendo.2016.00030 .
Fuster JJ, Ouchi N, Gokce N, Walsh K. Obesity-induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease. Circ Res. 2016;118:1786–807. https://doi.org/10.1161/CIRCRESAHA.115.306885 .
pubmed: 27230642
pmcid: 4887147
Greenberg AS, Obin MS. Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr. 2006;83:461S-465S. https://doi.org/10.1093/ajcn/83.2.461S .
pubmed: 16470013
Haczeyni F, Bell-Anderson KS, Farrell GC. Causes and mechanisms of adipocyte enlargement and adipose expansion. Obes Rev Off J Int Assoc Study Obes. 2018;19:406–20. https://doi.org/10.1111/obr.12646 .
Clemente-Suárez VJ, Redondo-Flórez L, Beltrán-Velasco AI, Martín-Rodríguez A, Martínez-Guardado I, Navarro-Jiménez E, et al. The Role of Adipokines in Health and Disease. Biomedicines. 2023;11:1290. https://doi.org/10.3390/biomedicines11051290 .
pubmed: 37238961
pmcid: 10216288
Ahima RS, Flier JS. Adipose Tissue as an Endocrine Organ. Trends Endocrinol Metab. 2000;11:327–32. https://doi.org/10.1016/S1043-2760(00)00301-5 .
pubmed: 10996528
Kershaw EE, Flier JS. Adipose Tissue as an Endocrine Organ. J Clin Endocrinol Metab. 2004;89:2548–56. https://doi.org/10.1210/jc.2004-0395 .
pubmed: 15181022
Li S, Shin HJ, Ding EL, van Dam RM. Adiponectin Levels and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis. JAMA. 2009;302:179–88. https://doi.org/10.1001/jama.2009.976 .
pubmed: 19584347
Gariballa S, Alkaabi J, Yasin J, Al EA. Total adiponectin in overweight and obese subjects and its response to visceral fat loss. BMC Endocr Disord. 2019;19:55. https://doi.org/10.1186/s12902-019-0386-z .
pubmed: 31159801
pmcid: 6545728
Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, Esquivel-Soto J, Morales-González A, Esquivel-Chirino C, et al. Inflammation, oxidative stress, and obesity. Int J Mol Sci. 2011;12:3117–32. https://doi.org/10.3390/ijms12053117 .
pubmed: 21686173
pmcid: 3116179
de Mello AH, Costa AB, Engel JDG, Rezin GT. Mitochondrial dysfunction in obesity. Life Sci. 2018;192:26–32. https://doi.org/10.1016/j.lfs.2017.11.019 .
pubmed: 29155300
Bournat JC, Brown CW. Mitochondrial Dysfunction in Obesity. Curr Opin Endocrinol Diabetes Obes. 2010;17:446–52. https://doi.org/10.1097/MED.0b013e32833c3026 .
pubmed: 20585248
pmcid: 5001554
Vyas CM, Ogata S, Iii CFR, Mischoulon D, Chang G, Cook NR, et al. Lifestyle and behavioral factors and mitochondrial DNA copy number in a diverse cohort of mid-life and older adults. PLoS ONE. 2020;15: e0237235. https://doi.org/10.1371/journal.pone.0237235 .
pubmed: 32785256
pmcid: 7423118
Filograna R, Mennuni M, Alsina D, Larsson N-G. Mitochondrial DNA copy number in human disease: the more the better? FEBS Lett. 2021;595:976–1002. https://doi.org/10.1002/1873-3468.14021 .
pubmed: 33314045
Castellani CA, Longchamps RJ, Sumpter JA, Newcomb CE, Lane JA, Grove ML, et al. Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs. Genome Med. 2020;12:84. https://doi.org/10.1186/s13073-020-00778-7 .
pubmed: 32988399
pmcid: 7523322
Hunter CA, Kartal F, Koc ZC, Murphy T, Kim JH, Denvir J, et al. Mitochondrial oxidative phosphorylation is impaired in TALLYHO mice, a new obesity and type 2 diabetes animal model. Int J Biochem Cell Biol. 2019;116: 105616. https://doi.org/10.1016/j.biocel.2019.105616 .
pubmed: 31542429
pmcid: 6996300
Brestoff JR, Wilen CB, Moley JR, Li Y, Zou W, Malvin NP, et al. Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity. Cell Metab. 2021;33:270-282.e8. https://doi.org/10.1016/j.cmet.2020.11.008 .
pubmed: 33278339
Schöttl T, Kappler L, Fromme T, Klingenspor M. Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status. Mol Metab. 2015;4:631–42. https://doi.org/10.1016/j.molmet.2015.07.001 .
pubmed: 26413469
pmcid: 4563017
Heinonen S, Muniandy M, Buzkova J, Mardinoglu A, Rodríguez A, Frühbeck G, et al. Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins. Diabetologia. 2017;60:169–81. https://doi.org/10.1007/s00125-016-4121-2 .
pubmed: 27734103
Honecker J, Ruschke S, Seeliger C, Laber S, Strobel S, Pröll P, et al. Transcriptome and fatty-acid signatures of adipocyte hypertrophy and its non-invasive MR-based characterization in human adipose tissue. eBioMedicine. 2022;79:104020. https://doi.org/10.1016/j.ebiom.2022.104020 .
pubmed: 35490555
pmcid: 9062743
Takamura T, Misu H, Matsuzawa-Nagata N, Sakurai M, Ota T, Shimizu A, et al. Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients. Obesity. 2008;16:2601–9. https://doi.org/10.1038/oby.2008.419 .
pubmed: 18846047
Chattopadhyay M, Khemka VK, Chatterjee G, Ganguly A, Mukhopadhyay S, Chakrabarti S. Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects. Mol Cell Biochem. 2015;399:95–103. https://doi.org/10.1007/s11010-014-2236-7 .
pubmed: 25312902
Lefranc C, Friederich-Persson M, Palacios-Ramirez R, Nguyen Dinh Cat A. Mitochondrial oxidative stress in obesity: role of the mineralocorticoid receptor. J Endocrinol 2018;238:R143–59. https://doi.org/10.1530/JOE-18-0163 .
van der Kolk BW, Muniandy M, Kaminska D, Alvarez M, Ko A, Miao Z, et al. Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery. J Clin Endocrinol Metab. 2021;106:1312–24. https://doi.org/10.1210/clinem/dgab072 .
pubmed: 33560372
pmcid: 8063261
Ngo DTM, Sverdlov AL, Karki S, Macartney-Coxson D, Stubbs RS, Farb MG, et al. Oxidative modifications of mitochondrial complex II are associated with insulin resistance of visceral fat in obesity. Am J Physiol-Endocrinol Metab. 2018;316:E168–77. https://doi.org/10.1152/ajpendo.00227.2018 .
pubmed: 30576243
pmcid: 6397365
Hadrava Vanova K, Kraus M, Neuzil J, Rohlena J. Mitochondrial complex II and reactive oxygen species in disease and therapy. Redox Rep Commun Free Radic Res n.d.;25:26–32. https://doi.org/10.1080/13510002.2020.1752002 .
Bezawork-Geleta A, Rohlena J, Dong L, Pacak K, Neuzil J. Mitochondrial Complex II: At the Crossroads. Trends Biochem Sci. 2017;42:312–25. https://doi.org/10.1016/j.tibs.2017.01.003 .
pubmed: 28185716
pmcid: 7441821
Varela-Rodríguez BM, Juiz-Valiña P, Varela L, Outeiriño-Blanco E, Bravo SB, García-Brao MJ, et al. Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissue. J Clin Med. 2020;9:213. https://doi.org/10.3390/jcm9010213 .
pubmed: 31941045
pmcid: 7019912
Yin X, Lanza IR, Swain JM, Sarr MG, Nair KS, Jensen MD. Adipocyte Mitochondrial Function Is Reduced in Human Obesity Independent of Fat Cell Size. J Clin Endocrinol Metab. 2014;99:E209–16. https://doi.org/10.1210/jc.2013-3042 .
pubmed: 24276464
Taylor RW, Turnbull DM. Mitochondrial DNA mutations in human disease. Nat Rev Genet. 2005;6:389–402. https://doi.org/10.1038/nrg1606 .
pubmed: 15861210
pmcid: 1762815
Parakatselaki M-E, Ladoukakis ED. mtDNA Heteroplasmy: Origin, Detection, Significance, and Evolutionary Consequences. Life. 2021;11:633. https://doi.org/10.3390/life11070633 .
pubmed: 34209862
pmcid: 8307225
Stewart JB, Chinnery PF. The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease. Nat Rev Genet. 2015;16:530–42. https://doi.org/10.1038/nrg3966 .
pubmed: 26281784
Rossignol R, Faustin B, Rocher C, Malgat M, Mazat J-P, Letellier T. Mitochondrial threshold effects. Biochem J. 2003;370:751–62. https://doi.org/10.1042/BJ20021594 .
pubmed: 12467494
pmcid: 1223225
Holt IJ, Harding AE, Petty RK, Morgan-Hughes JA. A new mitochondrial disease associated with mitochondrial DNA heteroplasmy. Am J Hum Genet. 1990;46:428–33.
pubmed: 2137962
pmcid: 1683641
Stewart JB, Chinnery PF. Extreme heterogeneity of human mitochondrial DNA from organelles to populations. Nat Rev Genet. 2021;22:106–18. https://doi.org/10.1038/s41576-020-00284-x .
pubmed: 32989265
Knoll N, Jarick I, Volckmar A-L, Klingenspor M, Illig T, Grallert H, et al. Mitochondrial DNA Variants in Obesity. PLoS ONE. 2014;9: e94882. https://doi.org/10.1371/journal.pone.0094882 .
pubmed: 24788344
pmcid: 4008486
Yang T-L, Guo Y, Shen H, Lei S-F, Liu Y-J, Li J, et al. Genetic Association Study of Common Mitochondrial Variants on Body Fat Mass. PLoS ONE. 2011;6: e21595. https://doi.org/10.1371/journal.pone.0021595 .
pubmed: 21747914
pmcid: 3126834
Demir D, Türkkahraman D, Samur AA, Lüleci G, Akçurin S, M. Alper Ö. Mitochondrial ATPase Subunit 6 and Cytochrome B Gene Variations in Obese Turkish Children. J Clin Res Pediatr Endocrinol 2014;6:209–15. https://doi.org/10.4274/jcrpe.1601 .
Okura T, Koda M, Ando F, Niino N, Tanaka M, Shimokata H. Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population. Hum Genet. 2003;113:432–6. https://doi.org/10.1007/s00439-003-0983-8 .
pubmed: 12905068
Wang Y, Palmfeldt J, Gregersen N, Makhov AM, Conway JF, Wang M, et al. Mitochondrial fatty acid oxidation and the electron transport chain comprise a multifunctional mitochondrial protein complex. J Biol Chem. 2019;294:12380–91. https://doi.org/10.1074/jbc.RA119.008680 .
pubmed: 31235473
pmcid: 6699831
Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114:1752–61. https://doi.org/10.1172/JCI200421625 .
pubmed: 15599400
pmcid: 535065
Flaquer A, Baumbach C, Kriebel J, Meitinger T, Peters A, Waldenberger M, et al. Mitochondrial Genetic Variants Identified to Be Associated with BMI in Adults. PLoS ONE. 2014;9: e105116. https://doi.org/10.1371/journal.pone.0105116 .
pubmed: 25153900
pmcid: 4143221
Grant SFA, Glessner JT, Bradfield JP, Zhao J, Tirone JE, Berkowitz RI, et al. Lack of relationship between mitochondrial heteroplasmy or variation and childhood obesity. Int J Obes. 2012;36:80–3. https://doi.org/10.1038/ijo.2011.206 .
Rivera MA, Pérusse L, Gagnon J, Dionne FT, Leon AS, Rao DC, et al. A mitochondrial DNA D-loop polymorphism and obesity in three cohorts of women. Int J Obes. 1999;23:666–8. https://doi.org/10.1038/sj.ijo.0800900 .
Mishmar D, Ruiz-Pesini E, Golik P, Macaulay V, Clark AG, Hosseini S, et al. Natural selection shaped regional mtDNA variation in humans. Proc Natl Acad Sci. 2003;100:171–6. https://doi.org/10.1073/pnas.0136972100 .
pubmed: 12509511
Van Oven M, Kayser M. Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum Mutat. 2009;30:E386–94. https://doi.org/10.1002/humu.20921 .
pubmed: 18853457
PhyloTree.org | tree | main n.d. https://www.phylotree.org/tree/index.htm (accessed February 23, 2024).
Chalkia D, Chang Y-C, Derbeneva O, Lvova M, Wang P, Mishmar D, et al. Mitochondrial DNA associations with East Asian metabolic syndrome. Biochim Biophys Acta Bioenerg. 2018;1859:878–92. https://doi.org/10.1016/j.bbabio.2018.07.002 .
pubmed: 29997041
pmcid: 6530988
Fang EF, Lautrup S, Hou Y, Demarest TG, Croteau DL, Mattson MP, et al. NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends Mol Med. 2017;23:899–916. https://doi.org/10.1016/j.molmed.2017.08.001 .
pubmed: 28899755
pmcid: 7494058
Nardelli C, Labruna G, Liguori R, Mazzaccara C, Ferrigno M, Capobianco V, et al. Haplogroup T Is an Obesity Risk Factor: Mitochondrial DNA Haplotyping in a Morbid Obese Population from Southern Italy. BioMed Res Int. 2013;2013: 631082. https://doi.org/10.1155/2013/631082 .
pubmed: 23936828
pmcid: 3713591
Ebner S, Mangge H, Langhof H, Halle M, Siegrist M, Aigner E, et al. Mitochondrial Haplogroup T Is Associated with Obesity in Austrian Juveniles and Adults. PLoS ONE. 2015;10: e0135622. https://doi.org/10.1371/journal.pone.0135622 .
pubmed: 26322975
pmcid: 4556186
Castro MG, Terrados N, Reguero JR, Alvarez V, Coto E. Mitochondrial haplogroup T is negatively associated with the status of elite endurance athlete. Mitochondrion. 2007;7:354–7. https://doi.org/10.1016/j.mito.2007.06.002 .
pubmed: 17660050
Dashti M, Alsaleh H, Rodriguez-Flores JL, Eaaswarkhanth M, Al-Mulla F, Thanaraj TA. Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population. Sci Rep. 2021;11:1091. https://doi.org/10.1038/s41598-020-80040-7 .
pubmed: 33441698
pmcid: 7806807
Veronese N, Stubbs B, Koyanagi A, Vaona A, Demurtas J, Schofield P, et al. Mitochondrial genetic haplogroups and incident obesity: a longitudinal cohort study. Eur J Clin Nutr. 2018;72:587–92. https://doi.org/10.1038/s41430-018-0097-y .
pubmed: 29386643
Sharma P, Sampath H. Mitochondrial DNA Integrity: Role in Health and Disease. Cells. 2019;8:100. https://doi.org/10.3390/cells8020100 .
pubmed: 30700008
pmcid: 6406942
Gustafson MA, Sullivan ED, Copeland WC. Consequences of Compromised Mitochondrial Genome Integrity. DNA Repair. 2020;93: 102916. https://doi.org/10.1016/j.dnarep.2020.102916 .
pubmed: 33087282
pmcid: 7587307
Picard M. Blood Mitochondrial DNA Copy Number: What Are We Counting? Mitochondrion. 2021;60:1–11. https://doi.org/10.1016/j.mito.2021.06.010 .
pubmed: 34157430
pmcid: 8464495
Bordoni L, Smerilli V, Nasuti C, Gabbianelli R. Mitochondrial DNA methylation and copy number predict body composition in a young female population. J Transl Med. 2019;17:399. https://doi.org/10.1186/s12967-019-02150-9 .
pubmed: 31779622
pmcid: 6883616
Lee J-Y, Lee D-C, Im J-A, Lee J-W. Mitochondrial DNA Copy Number in Peripheral Blood Is Independently Associated with Visceral Fat Accumulation in Healthy Young Adults. Int J Endocrinol. 2014;2014: 586017. https://doi.org/10.1155/2014/586017 .
pubmed: 24707289
pmcid: 3953665
Meng S, Wu S, Liang L, Liang G, Giovannucci E, Vivo ID, et al. Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women. Oncotarget 2016;7:60676–86. https://doi.org/10.18632/oncotarget.10325 .
Zheng LD, Linarelli LE, Liu L, Wall SS, Greenawald MH, Seidel RW, et al. Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans. Clin Epigenetics. 2015;7:60. https://doi.org/10.1186/s13148-015-0093-1 .
pubmed: 26110043
pmcid: 4479353
Liu X, Longchamps RJ, Wiggins KL, Raffield LM, Bielak LF, Zhao W, et al. Association of mitochondrial DNA copy number with cardiometabolic diseases. Cell Genomics. 2021;1: 100006. https://doi.org/10.1016/j.xgen.2021.100006 .
pubmed: 35036986
pmcid: 8758111
Hang D, Nan H, Kværner AS, De Vivo I, Chan AT, Hu Z, et al. Longitudinal associations of lifetime adiposity with leukocyte telomere length and mitochondrial DNA copy number. Eur J Epidemiol. 2018;33:485–95. https://doi.org/10.1007/s10654-018-0382-z .
pubmed: 29619669
pmcid: 8063494
Gyllenhammer LE, Entringer S, Buss C, Wadhwa PD. Developmental programming of mitochondrial biology: a conceptual framework and review. Proc R Soc B Biol Sci. 2020;287:20192713. https://doi.org/10.1098/rspb.2019.2713 .
Peng J, Ramatchandirin B, Pearah A, Maheshwari A, He L. Development and Functions of Mitochondria in Early Life. Newborn Clarksville Md. 2022;1:131–41. https://doi.org/10.5005/jp-journals-11002-0013 .
pubmed: 37206110
Diaz-Vegas A, Sanchez-Aguilera P, Krycer JR, Morales PE, Monsalves-Alvarez M, Cifuentes M, et al. Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases? Endocr Rev. 2020;41:bnaa005. https://doi.org/10.1210/endrev/bnaa005 .
pubmed: 32179913
pmcid: 7255501
Kaaman M, Sparks LM, van Harmelen V, Smith SR, Sjölin E, Dahlman I, et al. Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue. Diabetologia. 2007;50:2526–33. https://doi.org/10.1007/s00125-007-0818-6 .
pubmed: 17879081
Seo M, Kim H, Noh H, Jeon JS, Byun DW, Kim SH, et al. Effect of bariatric surgery on circulating and urinary mitochondrial DNA copy numbers in obesity with or without diabetes. BMJ Open Diabetes Res Care. 2020;8: e001372. https://doi.org/10.1136/bmjdrc-2020-001372 .
pubmed: 33020132
pmcid: 7536782
Lee H, Oh S, Yang W, Park R, Kim H, Jeon JS, et al. Bariatric Surgery Reduces Elevated Urinary Mitochondrial DNA Copy Number in Patients With Obesity. J Clin Endocrinol Metab. 2019;104:2257–66. https://doi.org/10.1210/jc.2018-01935 .
pubmed: 30657970
Mechta M, Ingerslev LR, Fabre O, Picard M, Barrès R. Evidence Suggesting Absence of Mitochondrial DNA Methylation. Front Genet 2017;8 https://doi.org/10.3389/fgene.2017.00166
Stoccoro A, Coppedè F. Mitochondrial DNA Methylation and Human Diseases. Int J Mol Sci. 2021;22:4594. https://doi.org/10.3390/ijms22094594 .
pubmed: 33925624
pmcid: 8123858
Bordoni L, Perugini J, Petracci I, Mercurio ED, Lezoche G, Guerrieri M, et al. Mitochondrial DNA in Visceral Adipose Tissue in Severe Obesity: From Copy Number to D-Loop Methylation. Front Biosci Landmark Ed 2022; 27:172. https://doi.org/10.31083/j.fbl2706172 .
Zong Y, Li H, Liao P, Chen L, Pan Y, Zheng Y, et al. Mitochondrial dysfunction: mechanisms and advances in therapy. Signal Transduct Target Ther. 2024;9:1–29. https://doi.org/10.1038/s41392-024-01839-8 .
Wu Z, Chen L, Guo W, Wang J, Ni H, Liu J, et al. Oral mitochondrial transplantation using nanomotors to treat ischaemic heart disease. Nat Nanotechnol 2024:1–11. https://doi.org/10.1038/s41565-024-01681-7 .
Lightowlers RN, Chrzanowska‐Lightowlers ZM, Russell OM. Mitochondrial transplantation—a possible therapeutic for mitochondrial dysfunction? EMBO Rep 2020 21:e50964. https://doi.org/10.15252/embr.202050964 .