MicroRNAs as Epigenetic Regulators of Obesity.
Adipocyte-derived microvesicles (ADMs)
Adipogenesis
Adiponectin
Cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT)/enhancer-binding protein (C/EBP)
Fatty acid binding protein 4 (FABP4)
Forkhead box protein O1 (FoxO1)
Insulin resistance
Interleukin 1 (IL-1) receptor-associated kinase-1 (IRAK-1)
Leptin
Lipid droplets
Lipotoxicity
Micro ribonucleic acid-143 (miR-143)
Micro-ribonucleic acid-103 (miR-103)
Micro-ribonucleic acid-148a (miR-148a)
Micro-ribonucleic acid-155 (miR-155)
Micro-ribonucleic acid-221 (miR-221)
Micro-ribonucleic acid-223 (miR-223)
Micro-ribonucleic acid-33 (miR-33)
Micro-ribonucleic acid-34 (miR-34)
Micro-ribonucleic acids (miRNAs)
Obesity
Oxidized low density lipoprotein (Ox-LDL)
Peroxisome proliferator-activated receptor-gamma (PPAR-γ)
Silent information regulator 1 (SIRT1)
Sterol regulatory element-binding protein (SREBP)
Toll-like receptor 4 (TLR4)
Triglyceride
Tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)
Tumor necrosis factor-alpha (TNF-α)
Weight loss
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
17
9
2024
pubmed:
17
9
2024
entrez:
17
9
2024
Statut:
ppublish
Résumé
In obesity, the process of adipogenesis largely determines the number of adipocytes in body fat depots. Adipogenesis is regulated by several adipocyte-selective micro-ribonucleic acids (miRNAs) and transcription factors that modulate adipocyte proliferation and differentiation. However, some miRNAs block the expression of master regulators of adipogenesis. Since the specific miRNAs display different expressions during adipogenesis, in mature adipocytes and permanent obesity, their use as biomarkers or therapeutic targets is feasible. Upregulated miRNAs in persistent obesity are downregulated during adipogenesis. Moreover, some of the downregulated miRNAs in obese individuals are upregulated in mature adipocytes. Induction of adipocyte stress and hypertrophy leads to the release of adipocyte-derived exosomes (AdEXs) that contain the cargo molecules, miRNAs. miRNAs are important messengers for intercellular communication involved in metabolic responses and have very specific signatures that direct the metabolic activity of target cells. While each miRNA targets multiple messenger RNAs (mRNAs), which may coordinate or antagonize each other's functions, several miRNAs are dysregulated in other tissues during obesity-related comorbidities. Deletion of the miRNA-processing enzyme DICER in pro-opiomelanocortin-expressing cells results in obesity, which is characterized by hyperphagia, increased adiposity, hyperleptinemia, defective glucose metabolism, and alterations in the pituitary-adrenal axis. In recent years, RNA-based therapeutical approaches have entered clinical trials as novel therapies against overweight and its complications. Development of lipid droplets, macrophage accumulation, macrophage polarization, tumor necrosis factor receptor-associated factor 6 activity, lipolysis, lipotoxicity, and insulin resistance are effectively controlled by miRNAs. Thereby, miRNAs as epigenetic regulators are used to determine the new gene transcripts and therapeutic targets.
Identifiants
pubmed: 39287866
doi: 10.1007/978-3-031-63657-8_20
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
595-627Informations de copyright
© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
Références
Adachi T, Toishi T, Wu H, Kamiya T, Hara H (2009) Expression of extracellular superoxide dismutase during adipose differentiation in 3T3-L1 cells. Redox Rep 14:34–40. https://doi.org/10.1179/135100009X392467
pubmed: 19161676
Ahmad R, Al-Mass A, Atizado V, Al-Hubail A, Al-Ghimlas F, Al-Arouj M, Bennakhi A, Dermime S, Behbehani K (2012) Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation. J Inflamm (Lond) 9:48. https://doi.org/10.1186/1476-9255-9-48
pubmed: 23191980
Alexander R, Lodish H, Sun L (2011) MicroRNAs in adipogenesis and as therapeutic targets for obesity. Expert Opin Ther Targets 15:623–636. https://doi.org/10.1517/14728222.2011.561317
pubmed: 21355787
pmcid: 3188954
Arias N, Aguirre L, Fernández-Quintela A, González M, Lasa A, Miranda J, Macarulla MT, Portillo MP (2016) MicroRNAs involved in the browning process of adipocytes. J Physiol Biochem 72:509–521. https://doi.org/10.1007/s13105-015-0459-z
pubmed: 26695012
Arner E, Mejhert N, Kulyté A, Balwierz PJ, Pachkov M, Cormont M, Lorente-Cebrián S, Ehrlund A, Laurencikiene J, Hedén P, Dahlman-Wright K, Tanti J-F, Hayashizaki Y, Rydén M, Dahlman I, van Nimwegen E, Daub CO, Arner P (2012) Adipose tissue microRNAs as regulators of CCL2 production in human obesity. Diabetes 61:1986–1993. https://doi.org/10.2337/db11-1508
pubmed: 22688341
pmcid: 3402332
Aryal NK, Pant V, Wasylishen AR, Parker-Thornburg J, Baseler L, El-Naggar AK, Liu B, Kalia A, Lozano G, Arur S (2019) Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo. Proc Natl Acad Sci USA 116:960–969. https://doi.org/10.1073/pnas.1814377116
pubmed: 30593561
Bargut TCL, Souza-Mello V, Aguila MB, Mandarim-de-Lacerda CA (2017) Browning of white adipose tissue: lessons from experimental models. Horm Mol Biol Clin Investig 31:20160051. https://doi.org/10.1515/hmbci-2016-0051
Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–297. https://doi.org/10.1016/s0092-8674(04)00045-5
pubmed: 14744438
Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136:215–233. https://doi.org/10.1016/j.cell.2009.01.002
pubmed: 19167326
pmcid: 3794896
Belarbi Y, Mejhert N, Lorente-Cebrián S, Dahlman I, Arner P, Rydén M, Kulyté A (2015) MicroRNA-193b controls adiponectin production in human white adipose tissue. J Clin Endocrinol Metab 100:E1084–E1088. https://doi.org/10.1210/jc.2015-1530
pubmed: 26020766
Bork S, Horn P, Castoldi M, Hellwig I, Ho AD, Wagner W (2011) Adipogenic differentiation of human mesenchymal stromal cells is down-regulated by microRNA-369-5p and up-regulated by microRNA-371. J Cell Physiol 226:2226–2234. https://doi.org/10.1002/jcp.22557
pubmed: 21660946
Bost F, Aouadi M, Caron L, Binétruy B (2005) The role of MAPKs in adipocyte differentiation and obesity. Biochimie 87:51–56. https://doi.org/10.1016/j.biochi.2004.10.018
pubmed: 15733737
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857–868. https://doi.org/10.1016/s0092-8674(00)80595-4
pubmed: 10102273
Campolo F, Catanzaro G, Venneri MA, Ferretti E, Besharat ZM (2022) MicroRNA loaded edible nanoparticles: an emerging personalized therapeutic approach for the treatment of obesity and metabolic disorders. Theranostics 12:2631–2634. https://doi.org/10.7150/thno.71399
pubmed: 35401814
pmcid: 8965492
Chakravarthy S, Sternberg SH, Kellenberger CA, Doudna JA (2010) Substrate-specific kinetics of Dicer-catalyzed RNA processing. J Mol Biol 404:392–402. https://doi.org/10.1016/j.jmb.2010.09.030
pubmed: 20932845
pmcid: 3005596
Chang C-L, Au L-C, Huang S-W, Fai Kwok C, Ho L-T, Juan C-C (2011) Insulin up-regulates heme oxygenase-1 expression in 3T3-L1 adipocytes via PI3-kinase- and PKC-dependent pathways and heme oxygenase-1-associated microRNA downregulation. Endocrinology 152:384–393. https://doi.org/10.1210/en.2010-0493
pubmed: 21147878
Chen T, Huang Z, Wang L, Wang Y, Wu F, Meng S, Wang C (2009) MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages. Cardiovasc Res 83:131–139. https://doi.org/10.1093/cvr/cvp121
pubmed: 19377067
Chen L, Song J, Cui J, Hou J, Zheng X, Li C, Liu L (2013) microRNAs regulate adipocyte differentiation. Cell Biol Int 37:533–546. https://doi.org/10.1002/cbin.10063
pubmed: 23504919
Chen L, Dai Y-M, Ji C-B, Yang L, Shi C-M, Xu G-F, Pang L-X, Huang F-Y, Zhang C-M, Guo X-R (2014) MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity. Mol Cell Endocrinol 393:65–74. https://doi.org/10.1016/j.mce.2014.05.022
pubmed: 24931160
Chen Y, Pan R, Pfeifer A (2017) Regulation of brown and beige fat by microRNAs. Pharmacol Ther 170:1–7. https://doi.org/10.1016/j.pharmthera.2016.10.004
pubmed: 27742571
Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K, Shiekhattar R (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436:740–744. https://doi.org/10.1038/nature03868
pubmed: 15973356
pmcid: 2944926
Chi J, Cohen P (2016) The multifaceted roles of PRDM16: adipose biology and beyond. Trends Endocrinol Metab 27:11–23. https://doi.org/10.1016/j.tem.2015.11.005
pubmed: 26688472
Choi S-E, Fu T, Seok S, Kim D-H, Yu E, Lee K-W, Kang Y, Li X, Kemper B, Kemper JK (2013) Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging Cell 12:1062–1072. https://doi.org/10.1111/acel.12135
pubmed: 23834033
Choy L, Derynck R (2003) Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J Biol Chem 278:9609–9619. https://doi.org/10.1074/jbc.M212259200
pubmed: 12524424
Choy L, Skillington J, Derynck R (2000) Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. J Cell Biol 149:667–682. https://doi.org/10.1083/jcb.149.3.667
pubmed: 10791980
pmcid: 2174852
Cioffi M, Vallespinos-Serrano M, Trabulo SM, Fernandez-Marcos PJ, Firment AN, Vazquez BN, Vieira CR, Mulero F, Camara JA, Cronin UP, Perez M, Soriano J, Galvez BG, Castells-Garcia A, Haage V, Raj D, Megias D, Hahn S, Serrano L, Moon A, Aicher A, Heeschen C (2015) MiR-93 controls adiposity via inhibition of Sirt7 and Tbx3. Cell Rep 12:1594–1605. https://doi.org/10.1016/j.celrep.2015.08.006
pubmed: 26321631
Clouthier DE, Comerford SA, Hammer RE (1997) Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. J Clin Invest 100:2697–2713. https://doi.org/10.1172/JCI119815
pubmed: 9389733
pmcid: 508473
Connolly KD, Guschina IA, Yeung V, Clayton A, Draman MS, Von Ruhland C, Ludgate M, James PE, Rees DA (2015) Characterisation of adipocyte-derived extracellular vesicles released pre- and post-adipogenesis. J Extracell Vesicles 4:29159. https://doi.org/10.3402/jev.v4.29159
pubmed: 26609807
Crandall DL, Hausman GJ, Kral JG (1997) A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 4:211–232. https://doi.org/10.3109/10739689709146786
pubmed: 9219215
Cristancho AG, Lazar MA (2011) Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 12:722–734. https://doi.org/10.1038/nrm3198
pubmed: 21952300
pmcid: 7171550
Dang S-Y, Leng Y, Wang Z-X, Xiao X, Zhang X, Wen T, Gong H-Z, Hong A, Ma Y (2019) Exosomal transfer of obesity adipose tissue for decreased miR-141-3p mediate insulin resistance of hepatocytes. Int J Biol Sci 15:351–368. https://doi.org/10.7150/ijbs.28522
pubmed: 30745826
pmcid: 6367552
Das SK, Stadelmeyer E, Schauer S, Schwarz A, Strohmaier H, Claudel T, Zechner R, Hoefler G, Vesely PW (2015) Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58. Int J Mol Sci 16:8555–8568. https://doi.org/10.3390/ijms16048555
pubmed: 25894224
pmcid: 4425096
de Ferranti S, Mozaffarian D (2008) The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem 54:945–955. https://doi.org/10.1373/clinchem.2007.100156
pubmed: 18436717
Deiuliis JA (2016) MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics. Int J Obes 40:88–101. https://doi.org/10.1038/ijo.2015.170
Denli AM, Tops BBJ, Plasterk RHA, Ketting RF, Hannon GJ (2004) Processing of primary microRNAs by the Microprocessor complex. Nature 432:231–235. https://doi.org/10.1038/nature03049
pubmed: 15531879
Doench JG, Petersen CP, Sharp PA (2003) siRNAs can function as miRNAs. Genes Dev 17:438–442. https://doi.org/10.1101/gad.1064703
pubmed: 12600936
pmcid: 195999
Dong P, Mai Y, Zhang Z, Mi L, Wu G, Chu G, Yang G, Sun S (2014) MiR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1. Acta Biochim Biophys Sin Shanghai 46:565–571. https://doi.org/10.1093/abbs/gmu043
pubmed: 24862853
Dooley J, Garcia-Perez JE, Sreenivasan J, Schlenner SM, Vangoitsenhoven R, Papadopoulou AS, Tian L, Schonefeldt S, Serneels L, Deroose C, Staats KA, Van der Schueren B, De Strooper B, McGuinness OP, Mathieu C, Liston A (2016) The microRNA-29 family dictates the balance between homeostatic and pathological glucose handling in diabetes and obesity. Diabetes 65:53–61. https://doi.org/10.2337/db15-0770
pubmed: 26696639
Dowell P, Otto TC, Adi S, Lane MD (2003) Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways. J Biol Chem 278:45485–45491. https://doi.org/10.1074/jbc.M309069200
pubmed: 12966085
Drenth JPH, Schattenberg JM (2020) The nonalcoholic steatohepatitis (NASH) drug development graveyard: established hurdles and planning for future success. Expert Opin Investig Drugs 29:1365–1375. https://doi.org/10.1080/13543784.2020.1839888
pubmed: 33074035
Eguchi A, Lazic M, Armando AM, Phillips SA, Katebian R, Maraka S, Quehenberger O, Sears DD, Feldstein AE (2016) Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J Mol Med (Berl) 94:1241–1253. https://doi.org/10.1007/s00109-016-1446-8
pubmed: 27394413
Engin A (2017) Adipose tissue hypoxia in obesity and its impact on preadipocytes and macrophages: hypoxia hypothesis. Adv Exp Med Biol 960:305–326. https://doi.org/10.1007/978-3-319-48382-5_13
pubmed: 28585205
Engin A, Engin AB (2021) Why should the molecular characterization of inflammasome-induced exosomal cargo be done? ExRNA 3. https://doi.org/10.21037/exrna-21-16
Engin AB, Engin A (2022) Adipogenesis-related microRNAs in obesity. ExRNA 4. https://doi.org/10.21037/exrna-22-4
Esau C, Kang X, Peralta E, Hanson E, Marcusson EG, Ravichandran LV, Sun Y, Koo S, Perera RJ, Jain R, Dean NM, Freier SM, Bennett CF, Lollo B, Griffey R (2004) MicroRNA-143 regulates adipocyte differentiation. J Biol Chem 279:52361–52365. https://doi.org/10.1074/jbc.C400438200
pubmed: 15504739
Estep JM, Goodman Z, Sharma H, Younossi E, Elarainy H, Baranova A, Younossi Z (2015) Adipocytokine expression associated with miRNA regulation and diagnosis of NASH in obese patients with NAFLD. Liver Int 35:1367–1372. https://doi.org/10.1111/liv.12555
pubmed: 24684403
Fan W, Morinaga H, Kim JJ, Bae E, Spann NJ, Heinz S, Glass CK, Olefsky JM (2010) FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J 29:4223–4236. https://doi.org/10.1038/emboj.2010.268
pubmed: 21045807
pmcid: 3018786
Ferrante SC, Nadler EP, Pillai DK, Hubal MJ, Wang Z, Wang JM, Gordish-Dressman H, Koeck E, Sevilla S, Wiles AA, Freishtat RJ (2015) Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease. Pediatr Res 77:447–454. https://doi.org/10.1038/pr.2014.202
pubmed: 25518011
Friedman RC, Farh KK-H, Burge CB, Bartel DP (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19:92–105. https://doi.org/10.1101/gr.082701.108
pubmed: 18955434
pmcid: 2612969
Furuhashi M, Hotamisligil GS (2008) Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov 7:489–503. https://doi.org/10.1038/nrd2589
pubmed: 18511927
pmcid: 2821027
Garcia RA, Roemmich JN, Claycombe KJ (2016) Evaluation of markers of beige adipocytes in white adipose tissue of the mouse. Nutr Metab (Lond) 13:24. https://doi.org/10.1186/s12986-016-0081-2
pubmed: 26997968
Ge Q, Brichard S, Yi X, Li Q (2014) microRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome. J Immunol Res 2014:987285. https://doi.org/10.1155/2014/987285
pubmed: 24741638
pmcid: 3987988
Gealekman O, Guseva N, Hartigan C, Apotheker S, Gorgoglione M, Gurav K, Tran K-V, Straubhaar J, Nicoloro S, Czech MP, Thompson M, Perugini RA, Corvera S (2011) Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation 123:186–194. https://doi.org/10.1161/CIRCULATIONAHA.110.970145
pubmed: 21200001
pmcid: 3334340
Gerin I, Bommer GT, McCoin CS, Sousa KM, Krishnan V, MacDougald OA (2010) Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis. Am J Physiol Endocrinol Metab 299:E198–E206. https://doi.org/10.1152/ajpendo.00179.2010
pubmed: 20484008
pmcid: 2928515
Gharanei S, Shabir K, Brown JE, Weickert MO, Barber TM, Kyrou I, Randeva HS (2020) Regulatory microRNAs in brown, brite and white adipose tissue. Cells 9:2489. https://doi.org/10.3390/cells9112489
pubmed: 33207733
pmcid: 7696849
Gharipour M, Sadeghi M (2013) Pivotal role of microRNA-33 in metabolic syndrome: a systematic review. ARYA Atheroscler 9:372–376
pubmed: 24575141
pmcid: 3933058
Gilad S, Meiri E, Yogev Y, Benjamin S, Lebanony D, Yerushalmi N, Benjamin H, Kushnir M, Cholakh H, Melamed N, Bentwich Z, Hod M, Goren Y, Chajut A (2008) Serum microRNAs are promising novel biomarkers. PLoS One 3:e3148. https://doi.org/10.1371/journal.pone.0003148
pubmed: 18773077
pmcid: 2519789
Goody D, Pfeifer A (2019) MicroRNAs in brown and beige fat. Biochim Biophys Acta Mol Cell Biol Lipids 1864:29–36. https://doi.org/10.1016/j.bbalip.2018.05.003
pubmed: 29758288
Guduric-Fuchs J, O’Connor A, Camp B, O’Neill CL, Medina RJ, Simpson DA (2012) Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types. BMC Genomics 13:357. https://doi.org/10.1186/1471-2164-13-357
pubmed: 22849433
pmcid: 3532190
Gustafson B, Gogg S, Hedjazifar S, Jenndahl L, Hammarstedt A, Smith U (2009) Inflammation and impaired adipogenesis in hypertrophic obesity in man. Am J Physiol Endocrinol Metab 297:E999–E1003. https://doi.org/10.1152/ajpendo.00377.2009
pubmed: 19622783
Ha M, Kim VN (2014) Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 15:509–524. https://doi.org/10.1038/nrm3838
pubmed: 25027649
Han J, Lee Y, Yeom K-H, Kim Y-K, Jin H, Kim VN (2004) The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 18:3016–3027. https://doi.org/10.1101/gad.1262504
pubmed: 15574589
pmcid: 535913
Hansson B, Medina A, Fryklund C, Fex M, Stenkula KG (2016) Serotonin (5-HT) and 5-HT2A receptor agonists suppress lipolysis in primary rat adipose cells. Biochem Biophys Res Commun 474:357–363. https://doi.org/10.1016/j.bbrc.2016.04.110
pubmed: 27109474
He A, Zhu L, Gupta N, Chang Y, Fang F (2007) Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. Mol Endocrinol 21:2785–2794. https://doi.org/10.1210/me.2007-0167
pubmed: 17652184
He H, Chen K, Wang F, Zhao L, Wan X, Wang L, Mo Z (2015) miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/β-catenin signaling. Int J Mol Med 35:1587–1595. https://doi.org/10.3892/ijmm.2015.2160
pubmed: 25847080
pmcid: 4432921
Heilbronn LK, Campbell LV (2008) Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr Pharm Des 14:1225–1230. https://doi.org/10.2174/138161208784246153
pubmed: 18473870
Heneghan HM, Miller N, McAnena OJ, O’Brien T, Kerin MJ (2011) Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers. J Clin Endocrinol Metab 96:E846–E850. https://doi.org/10.1210/jc.2010-2701
pubmed: 21367929
Holland JD, Klaus A, Garratt AN, Birchmeier W (2013) Wnt signaling in stem and cancer stem cells. Curr Opin Cell Biol 25:254–264. https://doi.org/10.1016/j.ceb.2013.01.004
pubmed: 23347562
Hsieh C-H, Rau C-S, Wu S-C, Yang JC-S, Wu Y-C, Lu T-H, Tzeng S-L, Wu C-J, Lin C-W (2015) Weight-reduction through a low-fat diet causes differential expression of circulating microRNAs in obese C57BL/6 mice. BMC Genomics 16:699. https://doi.org/10.1186/s12864-015-1896-3
pubmed: 26377847
pmcid: 4571067
Huang R, Hu G, Lin B, Lin Z, Sun C (2010) MicroRNA-155 silencing enhances inflammatory response and lipid uptake in oxidized low-density lipoprotein-stimulated human THP-1 macrophages. J Investig Med 58:961–967. https://doi.org/10.2310/JIM.0b013e3181ff46d7
pubmed: 21030878
Huang T-C, Sahasrabuddhe NA, Kim M-S, Getnet D, Yang Y, Peterson JM, Ghosh B, Chaerkady R, Leach SD, Marchionni L, Wong GW, Pandey A (2012) Regulation of lipid metabolism by Dicer revealed through SILAC mice. J Proteome Res 11:2193–2205. https://doi.org/10.1021/pr2009884
pubmed: 22313051
pmcid: 3612551
Isa SA, Ruffino JS, Ahluwalia M, Thomas AW, Morris K, Webb R (2011) M2 macrophages exhibit higher sensitivity to oxLDL-induced lipotoxicity than other monocyte/macrophage subtypes. Lipids Health Dis 10:229. https://doi.org/10.1186/1476-511X-10-229
pubmed: 22146099
pmcid: 3281809
Isakson P, Hammarstedt A, Gustafson B, Smith U (2009) Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Diabetes 58:1550–1557. https://doi.org/10.2337/db08-1770
pubmed: 19351711
pmcid: 2699851
Izquierdo-Lahuerta A, Martínez-García C, Medina-Gómez G (2016) Lipotoxicity as a trigger factor of renal disease. J Nephrol 29:603–610. https://doi.org/10.1007/s40620-016-0278-5
pubmed: 26956132
Ji C, Guo X (2019) The clinical potential of circulating microRNAs in obesity. Nat Rev Endocrinol 15:731–743. https://doi.org/10.1038/s41574-019-0260-0
pubmed: 31611648
Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840–846. https://doi.org/10.1038/nature05482
pubmed: 17167471
Kajimoto K, Naraba H, Iwai N (2006) MicroRNA and 3T3-L1 pre-adipocyte differentiation. RNA 12:1626–1632. https://doi.org/10.1261/rna.7228806
pubmed: 16870994
pmcid: 1557704
Kang M, Yan LM, Li YM, Zhang WY, Wang H, Tang AZ, Ou HS (2013a) Inhibitory effect of microRNA-24 on fatty acid-binding protein expression on 3T3-L1 adipocyte differentiation. Genet Mol Res 12:5267–5277. https://doi.org/10.4238/2013.November.7.1
pubmed: 24301787
Kang M, Yan L-M, Zhang W-Y, Li Y-M, Tang A-Z, Ou H-S (2013b) Role of microRNA-21 in regulating 3T3-L1 adipocyte differentiation and adiponectin expression. Mol Biol Rep 40:5027–5034. https://doi.org/10.1007/s11033-013-2603-6
pubmed: 23793828
Karbiener M, Fischer C, Nowitsch S, Opriessnig P, Papak C, Ailhaud G, Dani C, Amri E-Z, Scheideler M (2009) microRNA miR-27b impairs human adipocyte differentiation and targets PPARgamma. Biochem Biophys Res Commun 390:247–251. https://doi.org/10.1016/j.bbrc.2009.09.098
pubmed: 19800867
Kato Y, Tapping RI, Huang S, Watson MH, Ulevitch RJ, Lee JD (1998) Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature 395:713–716. https://doi.org/10.1038/27234
pubmed: 9790194
Kawamura Y, Tanaka Y, Kawamori R, Maeda S (2006) Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line. Mol Endocrinol 20:844–856. https://doi.org/10.1210/me.2005-0138
pubmed: 16339272
Kim DH, Burgess AP, Li M, Tsenovoy PL, Addabbo F, McClung JA, Puri N, Abraham NG (2008a) Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells. J Pharmacol Exp Ther 325:833–840. https://doi.org/10.1124/jpet.107.135285
pubmed: 18334666
Kim K, Perroud B, Espinal G, Kachinskas D, Austrheim-Smith I, Wolfe BM, Warden CH (2008b) Genes and networks expressed in perioperative omental adipose tissue are correlated with weight loss from Roux-en-Y gastric bypass. Int J Obes 32:1395–1406. https://doi.org/10.1038/ijo.2008.106
Kim YJ, Hwang SJ, Bae YC, Jung JS (2009) MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue. Stem Cells 27:3093–3102. https://doi.org/10.1002/stem.235
pubmed: 19816956
Kim SY, Kim AY, Lee HW, Son YH, Lee GY, Lee J-W, Lee YS, Kim JB (2010) miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression. Biochem Biophys Res Commun 392:323–328. https://doi.org/10.1016/j.bbrc.2010.01.012
pubmed: 20060380
Kim Y-K, Kim B, Kim VN (2016) Re-evaluation of the roles of Drosha, Export in 5, and Dicer in microRNA biogenesis. Proc Natl Acad Sci USA 113:E1881–E1889. https://doi.org/10.1073/pnas.1602532113
pubmed: 26976605
pmcid: 4822641
Kim MS, Muallem S, Kim SH, Kwon KB, Kim MS (2019) Exosomal release through TRPML1-mediated lysosomal exocytosis is required for adipogenesis. Biochem Biophys Res Commun 510:409–415. https://doi.org/10.1016/j.bbrc.2019.01.115
pubmed: 30711251
pmcid: 9883805
Kinoshita M, Ono K, Horie T, Nagao K, Nishi H, Kuwabara Y, Takanabe-Mori R, Hasegawa K, Kita T, Kimura T (2010) Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5. Mol Endocrinol 24:1978–1987. https://doi.org/10.1210/me.2010-0054
pubmed: 20719859
pmcid: 5417392
Klöting N, Berthold S, Kovacs P, Schön MR, Fasshauer M, Ruschke K, Stumvoll M, Blüher M (2009) MicroRNA expression in human omental and subcutaneous adipose tissue. PLoS One 4:e4699. https://doi.org/10.1371/journal.pone.0004699
pubmed: 19259271
pmcid: 2649537
Koumangoye RB, Sakwe AM, Goodwin JS, Patel T, Ochieng J (2011) Detachment of breast tumor cells induces rapid secretion of exosomes which subsequently mediate cellular adhesion and spreading. PLoS One 6:e24234. https://doi.org/10.1371/journal.pone.0024234
pubmed: 21915303
pmcid: 3167827
Kumar A, Ren Y, Sundaram K, Mu J, Sriwastva MK, Dryden GW, Lei C, Zhang L, Yan J, Zhang X, Park JW, Merchant ML, Teng Y, Zhang H-G (2021) miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (tnaA) gene. Theranostics 11:4061–4077. https://doi.org/10.7150/thno.52558
pubmed: 33754048
pmcid: 7977461
Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Otsu K, Kita T, Kimura T, Ono K (2015) MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway. Circ Res 116:279–288. https://doi.org/10.1161/CIRCRESAHA.116.304707
pubmed: 25362209
Lass A, Zimmermann R, Oberer M, Zechner R (2011) Lipolysis – a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res 50:14–27. https://doi.org/10.1016/j.plipres.2010.10.004
pubmed: 21087632
pmcid: 3031774
Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Rådmark O, Kim S, Kim VN (2003) The nuclear RNase III Drosha initiates microRNA processing. Nature 425:415–419. https://doi.org/10.1038/nature01957
pubmed: 14508493
Lee Y, Hur I, Park S-Y, Kim Y-K, Suh MR, Kim VN (2006) The role of PACT in the RNA silencing pathway. EMBO J 25:522–532. https://doi.org/10.1038/sj.emboj.7600942
pubmed: 16424907
pmcid: 1383527
Lee EK, Lee MJ, Abdelmohsen K, Kim W, Kim MM, Srikantan S, Martindale JL, Hutchison ER, Kim HH, Marasa BS, Selimyan R, Egan JM, Smith SR, Fried SK, Gorospe M (2011) miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol 31:626–638. https://doi.org/10.1128/MCB.00894-10
pubmed: 21135128
Lee J-E, Moon P-G, Lee I-K, Baek M-C (2015) Proteomic analysis of extracellular vesicles released by adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Protein J 34:220–235. https://doi.org/10.1007/s10930-015-9616-z
pubmed: 25998041
Lefterova MI, Lazar MA (2009) New developments in adipogenesis. Trends Endocrinol Metab 20:107–114. https://doi.org/10.1016/j.tem.2008.11.005
pubmed: 19269847
Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15–20. https://doi.org/10.1016/j.cell.2004.12.035
pubmed: 15652477
Li M, Kim DH, Tsenovoy PL, Peterson SJ, Rezzani R, Rodella LF, Aronow WS, Ikehara S, Abraham NG (2008) Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. Diabetes 57:1526–1535. https://doi.org/10.2337/db07-1764
pubmed: 18375438
Li H, Xue M, Xu J, Qin X (2016) MiR-301a is involved in adipocyte dysfunction during obesity-related inflammation via suppression of PPARγ. Pharmazie 71:84–88
pubmed: 27004372
Li X, Ballantyne LL, Yu Y, Funk CD (2019) Perivascular adipose tissue-derived extracellular vesicle miR-221-3p mediates vascular remodeling. FASEB J 33:12704–12722. https://doi.org/10.1096/fj.201901548R
pubmed: 31469602
pmcid: 6902668
Li C-J, Fang Q-H, Liu M-L, Lin J-N (2020) Current understanding of the role of adipose-derived extracellular vesicles in metabolic homeostasis and diseases: communication from the distance between cells/tissues. Theranostics 10:7422–7435. https://doi.org/10.7150/thno.42167
pubmed: 32642003
pmcid: 7330853
Li X, Zhang H, Wang Y, Li Y, He C, Zhu J, Xiong Y, Lin Y (2022) RNA-seq analysis reveals the positive role of KLF5 in the differentiation of subcutaneous adipocyte in goats. Gene 808:145969. https://doi.org/10.1016/j.gene.2021.145969
pubmed: 34530084
Lin Q, Gao Z, Alarcon RM, Ye J, Yun Z (2009) A role of miR-27 in the regulation of adipogenesis. FEBS J 276:2348–2358. https://doi.org/10.1111/j.1742-4658.2009.06967.x
pubmed: 19348006
pmcid: 5330386
Lin Y-Y, Chou C-F, Giovarelli M, Briata P, Gherzi R, Chen C-Y (2014) KSRP and MicroRNA 145 are negative regulators of lipolysis in white adipose tissue. Mol Cell Biol 34:2339–2349. https://doi.org/10.1128/MCB.00042-14
pubmed: 24732799
pmcid: 4054295
Ling H-Y, Ou H-S, Feng S-D, Zhang X-Y, Tuo Q-H, Chen L-X, Zhu B-Y, Gao Z-P, Tang C-K, Yin W-D, Zhang L, Liao D-F (2009) CHANGES IN microRNA (miR) profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes. Clin Exp Pharmacol Physiol 36:e32–e39. https://doi.org/10.1111/j.1440-1681.2009.05207.x
pubmed: 19473196
Ling H-Y, Wen G-B, Feng S-D, Tuo Q-H, Ou H-S, Yao CH, Zhu B-Y, Gao Z-P, Zhang L, Liao D-F (2011) MicroRNA-375 promotes 3T3-L1 adipocyte differentiation through modulation of extracellular signal-regulated kinase signalling. Clin Exp Pharmacol Physiol 38:239–246. https://doi.org/10.1111/j.1440-1681.2011.05493.x
pubmed: 21291493
pmcid: 3086632
Liu J, Wang H, Zeng D, Xiong J, Luo J, Chen X, Chen T, Xi Q, Sun J, Ren X, Zhang Y (2023) The novel importance of miR-143 in obesity regulation. Int J Obes 47:100–108. https://doi.org/10.1038/s41366-022-01245-6
Locke M, Feisst V, Dunbar PR (2011) Concise review: human adipose-derived stem cells: separating promise from clinical need. Stem Cells 29:404–411. https://doi.org/10.1002/stem.593
pubmed: 21425404
Longo KA, Wright WS, Kang S, Gerin I, Chiang S-H, Lucas PC, Opp MR, MacDougald OA (2004) Wnt10b inhibits development of white and brown adipose tissues. J Biol Chem 279:35503–35509. https://doi.org/10.1074/jbc.M402937200
pubmed: 15190075
Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117:175–184. https://doi.org/10.1172/JCI29881
pubmed: 17200717
pmcid: 1716210
Ma E, MacRae IJ, Kirsch JF, Doudna JA (2008) Autoinhibition of human dicer by its internal helicase domain. J Mol Biol 380:237–243. https://doi.org/10.1016/j.jmb.2008.05.005
pubmed: 18508075
pmcid: 2927216
Mang GM, Pradervand S, Du N-H, Arpat AB, Preitner F, Wigger L, Gatfield D, Franken P (2015) A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice. PLoS One 10:e0116760. https://doi.org/10.1371/journal.pone.0116760
pubmed: 25629159
pmcid: 4309537
Martinelli R, Nardelli C, Pilone V, Buonomo T, Liguori R, Castanò I, Buono P, Masone S, Persico G, Forestieri P, Pastore L, Sacchetti L (2010) miR-519d overexpression is associated with human obesity. Obesity (Silver Spring) 18:2170–2176. https://doi.org/10.1038/oby.2009.474
pubmed: 20057369
Masliah G, Barraud P, Allain FH-T (2013) RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence. Cell Mol Life Sci 70:1875–1895. https://doi.org/10.1007/s00018-012-1119-x
pubmed: 22918483
Mayr B, Montminy M (2001) Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2:599–609. https://doi.org/10.1038/35085068
pubmed: 11483993
McGregor RA, Choi MS (2011) microRNAs in the regulation of adipogenesis and obesity. Curr Mol Med 11:304–316. https://doi.org/10.2174/156652411795677990
pubmed: 21506921
pmcid: 3267163
Mleczko J, Ortega FJ, Falcon-Perez JM, Wabitsch M, Fernandez-Real JM, Mora S (2018) Extracellular vesicles from hypoxic adipocytes and obese subjects reduce insulin-stimulated glucose uptake. Mol Nutr Food Res 62:1700917. https://doi.org/10.1002/mnfr.201700917
pubmed: 29292863
pmcid: 5887919
Molgat ASD, Gagnon A, Foster C, Sorisky A (2012) The activation state of macrophages alters their ability to suppress preadipocyte apoptosis. J Endocrinol 214:21–29. https://doi.org/10.1530/JOE-12-0114
pubmed: 22556272
Monteys AM, Spengler RM, Wan J, Tecedor L, Lennox KA, Xing Y, Davidson BL (2010) Structure and activity of putative intronic miRNA promoters. RNA 16:495–505. https://doi.org/10.1261/rna.1731910
pubmed: 20075166
pmcid: 2822915
Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR (2012) Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab 16:336–347. https://doi.org/10.1016/j.cmet.2012.07.017
pubmed: 22958919
pmcid: 3461823
Mysore R, Zhou Y, Sädevirta S, Savolainen-Peltonen H, Nidhina Haridas PA, Soronen J, Leivonen M, Sarin A-P, Fischer-Posovszky P, Wabitsch M, Yki-Järvinen H, Olkkonen VM (2016) MicroRNA-192* impairs adipocyte triglyceride storage. Biochim Biophys Acta 1861:342–351. https://doi.org/10.1016/j.bbalip.2015.12.019
pubmed: 26747651
Nakanishi N, Nakagawa Y, Tokushige N, Aoki N, Matsuzaka T, Ishii K, Yahagi N, Kobayashi K, Yatoh S, Takahashi A, Suzuki H, Urayama O, Yamada N, Shimano H (2009) The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice. Biochem Biophys Res Commun 385:492–496. https://doi.org/10.1016/j.bbrc.2009.05.058
pubmed: 19460359
Ng R, Wu H, Xiao H, Chen X, Willenbring H, Steer CJ, Song G (2014) Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia. Hepatology 60:554–564. https://doi.org/10.1002/hep.27153
pubmed: 24677249
Nguyen MTA, Chen A, Lu WJ, Fan W, Li P-P, Oh DY, Patsouris D (2012) Regulation of chemokine and chemokine receptor expression by PPARγ in adipocytes and macrophages. PLoS One 7:e34976. https://doi.org/10.1371/journal.pone.0034976
pubmed: 22529965
pmcid: 3328487
Ogawa R, Tanaka C, Sato M, Nagasaki H, Sugimura K, Okumura K, Nakagawa Y, Aoki N (2010) Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation. Biochem Biophys Res Commun 398:723–729. https://doi.org/10.1016/j.bbrc.2010.07.008
pubmed: 20621060
Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, Suzuki R, Kitamura T, Akira S, Kadowaki T, Nagai R (2005) Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab 1:27–39. https://doi.org/10.1016/j.cmet.2004.11.005
pubmed: 16054042
Ortega FJ, Fernández-Real JM (2013) Inflammation in adipose tissue and fatty acid anabolism: when enough is enough! Horm Metab Res 45:1009–1019. https://doi.org/10.1055/s-0033-1358690
pubmed: 24277504
Ortega FJ, Moreno-Navarrete JM, Pardo G, Sabater M, Hummel M, Ferrer A, Rodriguez-Hermosa JI, Ruiz B, Ricart W, Peral B, Fernández-Real JM (2010) MiRNA expression profile of human subcutaneous adipose and during adipocyte differentiation. PLoS One 5:e9022. https://doi.org/10.1371/journal.pone.0009022
pubmed: 20126310
pmcid: 2814866
Ortega FJ, Mercader JM, Catalán V, Moreno-Navarrete JM, Pueyo N, Sabater M, Gómez-Ambrosi J, Anglada R, Fernández-Formoso JA, Ricart W, Frühbeck G, Fernández-Real JM (2013) Targeting the circulating microRNA signature of obesity. Clin Chem 59:781–792. https://doi.org/10.1373/clinchem.2012.195776
pubmed: 23396142
Ortega FJ, Mercader JM, Moreno-Navarrete JM, Nonell L, Puigdecanet E, Rodriquez-Hermosa JI, Rovira O, Xifra G, Guerra E, Moreno M, Mayas D, Moreno-Castellanos N, Fernández-Formoso JA, Ricart W, Tinahones FJ, Torrents D, Malagón MM, Fernández-Real JM (2015) Surgery-induced weight loss is associated with the downregulation of genes targeted by MicroRNAs in adipose tissue. J Clin Endocrinol Metab 100:E1467–E1476. https://doi.org/10.1210/jc.2015-2357
pubmed: 26252355
Pan D, Mao C, Quattrochi B, Friedline RH, Zhu LJ, Jung DY, Kim JK, Lewis B, Wang Y-X (2014) MicroRNA-378 controls classical brown fat expansion to counteract obesity. Nat Commun 5:4725. https://doi.org/10.1038/ncomms5725
pubmed: 25145289
Pandey AC, Semon JA, Kaushal D, O’Sullivan RP, Glowacki J, Gimble JM, Bunnell BA (2011) MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells. Stem Cell Res Ther 2:49. https://doi.org/10.1186/scrt90
pubmed: 22169120
pmcid: 3340558
Parra P, Serra F, Palou A (2010) Expression of adipose microRNAs is sensitive to dietary conjugated linoleic acid treatment in mice. PLoS One 5:e13005. https://doi.org/10.1371/journal.pone.0013005
pubmed: 20886002
pmcid: 2946340
Pasarica M, Sereda OR, Redman LM, Albarado DC, Hymel DT, Roan LE, Rood JC, Burk DH, Smith SR (2009) Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes 58:718–725. https://doi.org/10.2337/db08-1098
pubmed: 19074987
pmcid: 2646071
Peng Y, Yu S, Li H, Xiang H, Peng J, Jiang S (2014) MicroRNAs: emerging roles in adipogenesis and obesity. Cell Signal 26:1888–1896. https://doi.org/10.1016/j.cellsig.2014.05.006
pubmed: 24844591
Prats-Puig A, Ortega FJ, Mercader JM, Moreno-Navarrete JM, Moreno M, Bonet N, Ricart W, López-Bermejo A, Fernández-Real JM (2013) Changes in circulating microRNAs are associated with childhood obesity. J Clin Endocrinol Metab 98:E1655–E1660. https://doi.org/10.1210/jc.2013-1496
pubmed: 23928666
Pratt AJ, MacRae IJ (2009) The RNA-induced silencing complex: a versatile gene-silencing machine. J Biol Chem 284:17897–17901. https://doi.org/10.1074/jbc.R900012200
pubmed: 19342379
pmcid: 2709356
Price NL, Holtrup B, Kwei SL, Wabitsch M, Rodeheffer M, Bianchini L, Suárez Y, Fernández-Hernando C (2016) SREBP-1c/microRNA 33b genomic loci control adipocyte differentiation. Mol Cell Biol 36:1180–1193. https://doi.org/10.1128/MCB.00745-15
pubmed: 26830228
pmcid: 4800797
Rome S, Blandin A, Le Lay S (2021) Adipocyte-derived extracellular vesicles: state of the art. Int J Mol Sci 22:1788. https://doi.org/10.3390/ijms22041788
pubmed: 33670146
pmcid: 7916840
Rosen ED, MacDougald OA (2006) Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7:885–896. https://doi.org/10.1038/nrm2066
pubmed: 17139329
Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL, MacDougald OA (2000) Inhibition of adipogenesis by Wnt signaling. Science 289:950–953. https://doi.org/10.1126/science.289.5481.950
pubmed: 10937998
Roush S, Slack FJ (2008) The let-7 family of microRNAs. Trends Cell Biol 18:505–516. https://doi.org/10.1016/j.tcb.2008.07.007
pubmed: 18774294
Ruby JG, Jan CH, Bartel DP (2007) Intronic microRNA precursors that bypass Drosha processing. Nature 448:83–86. https://doi.org/10.1038/nature05983
pubmed: 17589500
pmcid: 2475599
Samuel CE (2019) Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA-triggered innate immune responses. J Biol Chem 294:1710–1720. https://doi.org/10.1074/jbc.TM118.004166
pubmed: 30710018
pmcid: 6364763
Sangiao-Alvarellos S, Theofilatos K, Barwari T, Gutmann C, Takov K, Singh B, Juiz-Valiña P, Varela-Rodríguez BM, Outeiriño-Blanco E, Duregotti E, Zampetaki A, Lunger L, Ebenbichler C, Tilg H, García-Brao MJ, Willeit P, Mena E, Kiechl S, Cordido F, Mayr M (2020) Metabolic recovery after weight loss surgery is reflected in serum microRNAs. BMJ Open Diabetes Res Care 8:e001441. https://doi.org/10.1136/bmjdrc-2020-001441
pubmed: 33115818
pmcid: 7594349
Sano S, Izumi Y, Yamaguchi T, Yamazaki T, Tanaka M, Shiota M, Osada-Oka M, Nakamura Y, Wei M, Wanibuchi H, Iwao H, Yoshiyama M (2014) Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells. Biochem Biophys Res Commun 445:327–333. https://doi.org/10.1016/j.bbrc.2014.01.183
pubmed: 24513287
Schneeberger M, Altirriba J, García A, Esteban Y, Castaño C, García-Lavandeira M, Alvarez CV, Gomis R, Claret M (2012) Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity. Mol Metab 2:74–85. https://doi.org/10.1016/j.molmet.2012.10.001
pubmed: 24199146
pmcid: 3817393
Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R, Rajewsky N (2008) Widespread changes in protein synthesis induced by microRNAs. Nature 455:58–63. https://doi.org/10.1038/nature07228
pubmed: 18668040
Shan T, Zhang P, Jiang Q, Xiong Y, Wang Y, Kuang S (2016) Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice. Diabetologia 59:1995–2004. https://doi.org/10.1007/s00125-016-4006-4
pubmed: 27294611
pmcid: 5345851
Sharma H, Estep M, Birerdinc A, Afendy A, Moazzez A, Elariny H, Goodman Z, Chandhoke V, Baranova A, Younossi ZM (2013) Expression of genes for microRNA-processing enzymes is altered in advanced non-alcoholic fatty liver disease. J Gastroenterol Hepatol 28:1410–1415. https://doi.org/10.1111/jgh.12268
pubmed: 23663110
Shi C, Zhang M, Tong M, Yang L, Pang L, Chen L, Xu G, Chi X, Hong Q, Ni Y, Ji C, Guo X (2015) miR-148a is associated with obesity and modulates adipocyte differentiation of mesenchymal stem cells through Wnt signaling. Sci Rep 5:9930. https://doi.org/10.1038/srep09930
pubmed: 26001136
pmcid: 4441322
Shi C, Huang F, Gu X, Zhang M, Wen J, Wang X, You L, Cui X, Ji C, Guo X (2016) Adipogenic miRNA and meta-signature miRNAs involved in human adipocyte differentiation and obesity. Oncotarget 7:40830–40845. https://doi.org/10.18632/oncotarget.8518
pubmed: 27049726
pmcid: 5130048
Smas CM, Sul HS (1993) Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 73:725–734. https://doi.org/10.1016/0092-8674(93)90252-l
pubmed: 8500166
Song G, Xu G, Ji C, Shi C, Shen Y, Chen L, Zhu L, Yang L, Zhao Y, Guo X (2014) The role of microRNA-26b in human adipocyte differentiation and proliferation. Gene 533:481–487. https://doi.org/10.1016/j.gene.2013.10.011
pubmed: 24140453
Song M, Han L, Chen F-F, Wang D, Wang F, Zhang L, Wang Z-H, Zhong M, Tang M-X, Zhang W (2018) Adipocyte-derived exosomes carrying sonic hedgehog mediate M1 macrophage polarization-induced insulin resistance via Ptch and PI3K pathways. Cell Physiol Biochem 48:1416–1432. https://doi.org/10.1159/000492252
pubmed: 30064125
Strum JC, Johnson JH, Ward J, Xie H, Feild J, Hester A, Alford A, Waters KM (2009) MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1. Mol Endocrinol 23:1876–1884. https://doi.org/10.1210/me.2009-0117
pubmed: 19819989
pmcid: 5419165
Sun T, Fu M, Bookout AL, Kliewer SA, Mangelsdorf DJ (2009) MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol Endocrinol 23:925–931. https://doi.org/10.1210/me.2008-0298
pubmed: 19324969
pmcid: 2691679
Takahashi Y, Satoh M, Minami Y, Tabuchi T, Itoh T, Nakamura M (2010) Expression of miR-146a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin-angiotensin system blockade and statins on miRNA-146a/b and Toll-like receptor 4 levels. Clin Sci (Lond) 119:395–405. https://doi.org/10.1042/CS20100003
pubmed: 20524934
Takanabe R, Ono K, Abe Y, Takaya T, Horie T, Wada H, Kita T, Satoh N, Shimatsu A, Hasegawa K (2008) Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. Biochem Biophys Res Commun 376:728–732. https://doi.org/10.1016/j.bbrc.2008.09.050
pubmed: 18809385
Tan CK, Leuenberger N, Tan MJ, Yan YW, Chen Y, Kambadur R, Wahli W, Tan NS (2011) Smad3 deficiency in mice protects against insulin resistance and obesity induced by a high-fat diet. Diabetes 60:464–476. https://doi.org/10.2337/db10-0801
pubmed: 21270259
pmcid: 3028346
Tian H, Liu C, Zou X, Wu W, Zhang C, Yuan D (2015) MiRNA-194 regulates palmitic acid-induced toll-like receptor 4 inflammatory responses in THP-1 cells. Nutrients 7:3483–3496. https://doi.org/10.3390/nu7053483
pubmed: 25984739
pmcid: 4446763
Tian L, Song Z, Shao W, Du WW, Zhao LR, Zeng K, Yang BB, Jin T (2017) Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2. Cell Death Dis 8:e2559. https://doi.org/10.1038/cddis.2016.455
pubmed: 28102847
pmcid: 5386366
Urbich C, Kuehbacher A, Dimmeler S (2008) Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res 79:581–588. https://doi.org/10.1093/cvr/cvn156
pubmed: 18550634
Vanella L, Sodhi K, Kim DH, Puri N, Maheshwari M, Hinds TD, Bellner L, Goldstein D, Peterson SJ, Shapiro JI, Abraham NG (2013) Increased heme-oxygenase 1 expression in mesenchymal stem cell-derived adipocytes decreases differentiation and lipid accumulation via upregulation of the canonical Wnt signaling cascade. Stem Cell Res Ther 4:28. https://doi.org/10.1186/scrt176
pubmed: 23497794
pmcid: 3706794
Vaughan T, Li L (2010) Molecular mechanism underlying the inflammatory complication of leptin in macrophages. Mol Immunol 47:2515–2518. https://doi.org/10.1016/j.molimm.2010.06.006
pubmed: 20619458
Vergani-Junior CA, Tonon-da-Silva G, Inan MD, Mori MA (2021) DICER: structure, function, and regulation. Biophys Rev 13:1081–1090. https://doi.org/10.1007/s12551-021-00902-w
pubmed: 35059029
pmcid: 8724510
Villard A, Marchand L, Thivolet C, Rome S (2015) Diagnostic value of cell-free circulating microRNAs for obesity and type 2 diabetes: a meta-analysis. J Mol Biomark Diagn 6:251. https://doi.org/10.4172/2155-9929.1000251
pubmed: 27308097
pmcid: 4905583
Vinnikov IA, Hajdukiewicz K, Reymann J, Beneke J, Czajkowski R, Roth LC, Novak M, Roller A, Dörner N, Starkuviene V, Theis FJ, Erfle H, Schütz G, Grinevich V, Konopka W (2014) Hypothalamic miR-103 protects from hyperphagic obesity in mice. J Neurosci 34:10659–10674. https://doi.org/10.1523/JNEUROSCI.4251-13.2014
pubmed: 25100599
pmcid: 6802591
Wahid F, Shehzad A, Khan T, Kim YY (2010) MicroRNAs: synthesis, mechanism, function, and recent clinical trials. Biochim Biophys Acta 1803:1231–1243. https://doi.org/10.1016/j.bbamcr.2010.06.013
pubmed: 20619301
Wang L, Xu L, Xu M, Liu G, Xing J, Sun C, Ding H (2015) Obesity-associated MiR-342-3p promotes adipogenesis of mesenchymal stem cells by suppressing CtBP2 and releasing C/EBPα from CtBP2 binding. Cell Physiol Biochem 35:2285–2298. https://doi.org/10.1159/000374032
pubmed: 25895816
Wei Y, Corbalán-Campos J, Gurung R, Natarelli L, Zhu M, Exner N, Erhard F, Greulich F, Geißler C, Uhlenhaut NH, Zimmer R, Schober A (2018) Dicer in macrophages prevents atherosclerosis by promoting mitochondrial oxidative metabolism. Circulation 138:2007–2020. https://doi.org/10.1161/CIRCULATIONAHA.117.031589
pubmed: 29748186
Whittaker R, Loy PA, Sisman E, Suyama E, Aza-Blanc P, Ingermanson RS, Price JH, McDonough PM (2010) Identification of MicroRNAs that control lipid droplet formation and growth in hepatocytes via high-content screening. J Biomol Screen 15:798–805. https://doi.org/10.1177/1087057110374991
pubmed: 20639500
Wieser V, Adolph TE, Grander C, Grabherr F, Enrich B, Moser P, Moschen AR, Kaser S, Tilg H (2018) Adipose type I interferon signalling protects against metabolic dysfunction. Gut 67:157–165. https://doi.org/10.1136/gutjnl-2016-313155
pubmed: 28011892
Wildwater M, Sander N, de Vreede G, van den Heuvel S (2011) Cell shape and Wnt signaling redundantly control the division axis of C. elegans epithelial stem cells. Development 138:4375–4385. https://doi.org/10.1242/dev.066431
pubmed: 21937595
Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang A-H, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150:366–376. https://doi.org/10.1016/j.cell.2012.05.016
pubmed: 22796012
pmcid: 3402601
Xiang X, Zhao J, Xu G, Li Y, Zhang W (2011) mTOR and the differentiation of mesenchymal stem cells. Acta Biochim Biophys Sin Shanghai 43:501–510. https://doi.org/10.1093/abbs/gmr041
pubmed: 21642276
Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M (2005) Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals. Nature 434:338–345. https://doi.org/10.1038/nature03441
pubmed: 15735639
pmcid: 2923337
Xie H, Lim B, Lodish HF (2009a) MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 58:1050–1057. https://doi.org/10.2337/db08-1299
pubmed: 19188425
pmcid: 2671055
Xie H, Sun L, Lodish HF (2009b) Targeting microRNAs in obesity. Expert Opin Ther Targets 13:1227–1238. https://doi.org/10.1517/14728220903190707
pubmed: 19650761
pmcid: 3197810
Xu G, Ji C, Song G, Zhao C, Shi C, Song L, Chen L, Yang L, Huang F, Pang L, Zhang N, Zhao Y, Guo X (2015) MiR-26b modulates insulin sensitivity in adipocytes by interrupting the PTEN/PI3K/AKT pathway. Int J Obes 39:1523–1530. https://doi.org/10.1038/ijo.2015.95
Yang Z, Bian C, Zhou H, Huang S, Wang S, Liao L, Zhao RC (2011) MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1. Stem Cells Dev 20:259–267. https://doi.org/10.1089/scd.2010.0072
pubmed: 20486779
Yang W-M, Jeong H-J, Park S-W, Lee W (2015) Obesity-induced miR-15b is linked causally to the development of insulin resistance through the repression of the insulin receptor in hepatocytes. Mol Nutr Food Res 59:2303–2314. https://doi.org/10.1002/mnfr.201500107
pubmed: 26179126
Yao Z-Y, Chen W-B, Shao S-S, Ma S-Z, Yang C-B, Li M-Z, Zhao J-J, Gao L (2018) Role of exosome-associated microRNA in diagnostic and therapeutic applications to metabolic disorders. J Zhejiang Univ Sci B 19:183–198. https://doi.org/10.1631/jzus.B1600490
pubmed: 29504312
pmcid: 5854634
Yeh C-L, Cheng I-C, Hou Y-C, Wang W, Yeh S-L (2014) MicroRNA-125a-3p expression in abdominal adipose tissues is associated with insulin signalling gene expressions in morbid obesity: observations in Taiwanese. Asia Pac J Clin Nutr 23:331–337. https://doi.org/10.6133/apjcn.2014.23.2.20
pubmed: 24901105
Yekta S, Shih I-H, Bartel DP (2004) MicroRNA-directed cleavage of HOXB8 mRNA. Science 304:594–596. https://doi.org/10.1126/science.1097434
pubmed: 15105502
Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, Li P, Olefsky JM (2017) Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity. Cell 171:372–384.e12. https://doi.org/10.1016/j.cell.2017.08.035
pubmed: 28942920
Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K (2014) SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway. Cell Metab 19:712–721. https://doi.org/10.1016/j.cmet.2014.03.006
pubmed: 24703702
Yu Z, Luo R, Li Y, Li X, Yang Z, Peng J, Huang K (2022) ADAR1 inhibits adipogenesis and obesity by interacting with Dicer to promote the maturation of miR-155-5P. J Cell Sci 135:jcs259333. https://doi.org/10.1242/jcs.259333
pubmed: 35067718
Zaragosi L-E, Wdziekonski B, Brigand KL, Villageois P, Mari B, Waldmann R, Dani C, Barbry P (2011) Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis. Genome Biol 12:R64. https://doi.org/10.1186/gb-2011-12-7-r64
pubmed: 21767385
pmcid: 3218826
Zhang H, Kolb FA, Jaskiewicz L, Westhof E, Filipowicz W (2004) Single processing center models for human Dicer and bacterial RNase III. Cell 118:57–68. https://doi.org/10.1016/j.cell.2004.06.017
pubmed: 15242644
Zhang M, Zhu W, Li Y (2014) Small molecule inhibitors of human adipocyte fatty acid binding protein (FABP4). Med Chem 10:339–347. https://doi.org/10.2174/15734064113096660045
pubmed: 24024500
Zhao X, Mohan R, Özcan S, Tang X (2012) MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP 4K4) in pancreatic β-cells. J Biol Chem 287:31155–31164. https://doi.org/10.1074/jbc.M112.362632
pubmed: 22733810
pmcid: 3438947
Zhou Y, Tan C (2020) miRNAs in adipocyte-derived extracellular vesicles: multiple roles in development of obesity-associated disease. Front Mol Biosci 7:171. https://doi.org/10.3389/fmolb.2020.00171
pubmed: 32850961
pmcid: 7403463
Zhu L, Chen L, Shi C-M, Xu G-F, Xu L-L, Zhu L-L, Guo X-R, Ni Y, Cui Y, Ji C (2014) MiR-335, an adipogenesis-related microRNA, is involved in adipose tissue inflammation. Cell Biochem Biophys 68:283–290. https://doi.org/10.1007/s12013-013-9708-3
pubmed: 23801157
Zhuang G, Meng C, Guo X, Cheruku PS, Shi L, Xu H, Li H, Wang G, Evans AR, Safe S, Wu C, Zhou B (2012) A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation 125:2892–2903. https://doi.org/10.1161/CIRCULATIONAHA.111.087817
pubmed: 22580331