Atomic vacancies of molybdenum disulfide nanoparticles stimulate mitochondrial biogenesis.

Molybdenum / pharmacology Disulfides / chemistry Mitochondria / metabolism Humans Nanoparticles / chemistry Organelle Biogenesis DNA, Mitochondrial / genetics Animals Adenosine Triphosphate / metabolism Mitochondrial Proteins / metabolism Mice

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
17 Sep 2024
Historique:
received: 13 08 2023
accepted: 02 09 2024
medline: 18 9 2024
pubmed: 18 9 2024
entrez: 17 9 2024
Statut: epublish

Résumé

Diminished mitochondrial function underlies many rare inborn errors of energy metabolism and contributes to more common age-associated metabolic and neurodegenerative disorders. Thus, boosting mitochondrial biogenesis has been proposed as a potential therapeutic approach for these diseases; however, currently we have a limited arsenal of compounds that can stimulate mitochondrial function. In this study, we designed molybdenum disulfide (MoS

Identifiants

DOI: 10.1038/s41467-024-52276-8 PMID: 39289340
pubmed: 39289340
doi: 10.1038/s41467-024-52276-8
pii: 10.1038/s41467-024-52276-8
doi:

Substances chimiques

Molybdenum 81AH48963U
Disulfides 0
molybdenum disulfide ZC8B4P503V
DNA, Mitochondrial 0
Adenosine Triphosphate 8L70Q75FXE
Mitochondrial Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8136

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR)
ID : DE032031
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB)
ID : EB026265
Organisme : United States Department of Defense | United States Army | Army Medical Command | Congressionally Directed Medical Research Programs (CDMRP)
ID : W81XWH2210932
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : NS121945
Organisme : Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas)
ID : RP230204
Organisme : U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics)
ID : CA282251
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R01GM143630
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R35GM152102

Informations de copyright

© 2024. The Author(s).

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Auteurs

Kanwar Abhay Singh (KA)

Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA.
ORCID: 0000-0001-9704-0495

John Soukar (J)

Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA.
Interdisiplinary program in Genetics and Genomics, Texas A&M University, College Station, TX, USA.
ORCID: 0000-0002-1175-2895

Mohammad Zulkifli (M)

Department of Biochemistry and Biophysics, College of Agriculture & Life Sciences, Texas A&M University, College Station, TX, USA.
ORCID: 0000-0002-9110-9508

Anna Kersey (A)

Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA.
Center for Remote Health Technologies and Systems, Texas A&M Engineering Experiment Station, College Station, TX, USA.

Giriraj Lokhande (G)

Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA.

Sagnika Ghosh (S)

Department of Biochemistry and Biophysics, College of Agriculture & Life Sciences, Texas A&M University, College Station, TX, USA.
ORCID: 0000-0003-2883-7008

Aparna Murali (A)

Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA.
Center for Remote Health Technologies and Systems, Texas A&M Engineering Experiment Station, College Station, TX, USA.

Natalie M Garza (NM)

Department of Biochemistry and Biophysics, College of Agriculture & Life Sciences, Texas A&M University, College Station, TX, USA.

Harman Kaur (H)

Department of Biochemistry and Biophysics, College of Agriculture & Life Sciences, Texas A&M University, College Station, TX, USA.

Justin N Keeney (JN)

Department of Cell biology and Genetics, College of Medicine, Texas A&M University, Bryan, TX, USA.
ORCID: 0000-0003-1748-0971

Ramu Banavath (R)

Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA.
Center for Remote Health Technologies and Systems, Texas A&M Engineering Experiment Station, College Station, TX, USA.
ORCID: 0000-0003-2618-4365

Hatice Ceylan Koydemir (H)

Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA.
Center for Remote Health Technologies and Systems, Texas A&M Engineering Experiment Station, College Station, TX, USA.
ORCID: 0000-0002-8612-5167

Raquel Sitcheran (R)

Interdisiplinary program in Genetics and Genomics, Texas A&M University, College Station, TX, USA.
Department of Cell biology and Genetics, College of Medicine, Texas A&M University, Bryan, TX, USA.
ORCID: 0000-0001-8916-9707

Irtisha Singh (I)

Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA. isingh@tamu.edu.
Interdisiplinary program in Genetics and Genomics, Texas A&M University, College Station, TX, USA. isingh@tamu.edu.
Department of Cell biology and Genetics, College of Medicine, Texas A&M University, Bryan, TX, USA. isingh@tamu.edu.
ORCID: 0000-0002-9460-3587

Vishal M Gohil (VM)

Interdisiplinary program in Genetics and Genomics, Texas A&M University, College Station, TX, USA. vgohil@tamu.edu.
Department of Biochemistry and Biophysics, College of Agriculture & Life Sciences, Texas A&M University, College Station, TX, USA. vgohil@tamu.edu.
ORCID: 0000-0002-9920-2563

Akhilesh K Gaharwar (AK)

Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, TX, USA. gaharwar@tamu.edu.
Interdisiplinary program in Genetics and Genomics, Texas A&M University, College Station, TX, USA. gaharwar@tamu.edu.
Department of Cell biology and Genetics, College of Medicine, Texas A&M University, Bryan, TX, USA. gaharwar@tamu.edu.
Department of Material Science and Engineering, College of Engineering, Texas A&M University, College Station, TX, USA. gaharwar@tamu.edu.
ORCID: 0000-0002-0284-0201

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Molybdène › Atomic vacancies of molybdenum disulfide...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfures › Disulfures › Atomic vacancies of molybdenum disulfide...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Atomic vacancies of molybdenum disulfide...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Atomic vacancies of molybdenum disulfide...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Atomic vacancies of molybdenum disulfide...
questionsmedicales.fr › Phénomènes biologiques › Biogenèse des organelles › Atomic vacancies of molybdenum disulfide...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › Atomic vacancies of molybdenum disulfide...
questionsmedicales.fr › Eucaryotes › Animaux › Atomic vacancies of molybdenum disulfide...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Atomic vacancies of molybdenum disulfide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Atomic vacancies of molybdenum disulfide...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Atomic vacancies of molybdenum disulfide...