Characterization of Shy1, the Schizosaccharomyces pombe homolog of human SURF1.
Schizosaccharomyces pombe
SURF1
Shy1
cytochrome c oxidase
mitochondria
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
17 Sep 2024
17 Sep 2024
Historique:
received:
19
02
2024
accepted:
10
09
2024
medline:
18
9
2024
pubmed:
18
9
2024
entrez:
17
9
2024
Statut:
epublish
Résumé
Cytochrome c oxidase (complex IV) is the terminal enzyme in the mitochondrial respiratory chain. As a rare neurometabolic disorder caused by mutations in the human complex IV assembly factor SURF1, Leigh Syndrome (LS) is associated with complex IV deficiency. In this study, we comprehensively characterized Schizosaccharomyces pombe Shy1, the homolog of human SURF1. Bioinformatics analysis revealed that Shy1 contains a conserved SURF1 domain that links to the biogenesis of complex IV and shares high structural similarity with its homologs in Saccharomyces cerevisiae and humans. Our study showed that Shy1 is required for the expression of mtDNA-encoded genes and physically interacts with structural subunits and assembly factors of complex IV. Interestingly, Rip1, the subunit of ubiquinone-cytochrome c oxidoreductase or cytochrome bc
Identifiants
pubmed: 39289458
doi: 10.1038/s41598-024-72681-9
pii: 10.1038/s41598-024-72681-9
doi:
Substances chimiques
Mitochondrial Proteins
0
Schizosaccharomyces pombe Proteins
0
Membrane Proteins
0
Electron Transport Complex IV
EC 1.9.3.1
Surf-1 protein
0
DNA, Mitochondrial
0
Mitochondrial Membrane Transport Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21678Subventions
Organisme : Graduate Research and Innovation Projects of Jiangsu Province
ID : KYCX23_1732
Organisme : China Scholarship Council
ID : No. 202306860040
Organisme : National Natural Science Foundation of China
ID : 31770810
Informations de copyright
© 2024. The Author(s).
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