Smoking and cluster headache presentation and responsiveness to treatment.
Cluster headache
Presentation
Responsiveness
Smoking
Journal
BMC neurology
ISSN: 1471-2377
Titre abrégé: BMC Neurol
Pays: England
ID NLM: 100968555
Informations de publication
Date de publication:
17 Sep 2024
17 Sep 2024
Historique:
received:
09
02
2024
accepted:
31
05
2024
medline:
18
9
2024
pubmed:
18
9
2024
entrez:
17
9
2024
Statut:
epublish
Résumé
Though an association between cluster headache (CH) and smoking has been postulated, data from the Middle East region is scarce. To study the relationship between smoking and CH clinical characteristics and responsiveness to therapy in Egypt. This was a prospective cohort hospital-based study conducted on patients with episodic and chronic CH in a tertiary headache clinic in Egypt during the period between 2019 and 2023. Patients were consecutively recruited at the time of their presentation and were followed up for two weeks after initiation of prophylactic treatment and steroids (as transitional therapy). Of 172 patients with CH recruited, 144 (83.7%) were smokers. Twenty-eight patients (16.3%) had chronic CH. The mean age was 42.08 ± 10.93 (20-66) years, and 131 (76.2%) were males. Smokers had a significantly higher median number of cluster bouts in the past five years (3.0 (IQR2.0-4.0) versus 2.0 (IQR 1.0-2.0)) and worse HIT-6 scores [51.0 (44.0-59.75) versus 41.0 (38.0-41.75)] than non-smokers (p < 0.001). The number of cluster bouts in the past five years was positively correlated with the smoking index (r = 0.249 (p = 0.006) and the smoking duration (in years) (r = 0.392 (p < 0.001)). HIT-6 scores were significantly correlated with the age at smoking onset (r=-0.190, = 0.023), smoking index (r = 0.519, p < 0.001), smoking duration (r = 0.611, p < 0.001), and number of cigarettes consumed per day (r = 0.392, p < 0.001). Smoking is significantly correlated with the daily frequency of CH attacks, the frequency of CH bouts in the past five years, and the HIT-6 scores among our cohort.
Sections du résumé
BACKGROUND
BACKGROUND
Though an association between cluster headache (CH) and smoking has been postulated, data from the Middle East region is scarce.
AIM OF WORK
OBJECTIVE
To study the relationship between smoking and CH clinical characteristics and responsiveness to therapy in Egypt.
METHODOLOGY
METHODS
This was a prospective cohort hospital-based study conducted on patients with episodic and chronic CH in a tertiary headache clinic in Egypt during the period between 2019 and 2023. Patients were consecutively recruited at the time of their presentation and were followed up for two weeks after initiation of prophylactic treatment and steroids (as transitional therapy).
RESULTS
RESULTS
Of 172 patients with CH recruited, 144 (83.7%) were smokers. Twenty-eight patients (16.3%) had chronic CH. The mean age was 42.08 ± 10.93 (20-66) years, and 131 (76.2%) were males. Smokers had a significantly higher median number of cluster bouts in the past five years (3.0 (IQR2.0-4.0) versus 2.0 (IQR 1.0-2.0)) and worse HIT-6 scores [51.0 (44.0-59.75) versus 41.0 (38.0-41.75)] than non-smokers (p < 0.001). The number of cluster bouts in the past five years was positively correlated with the smoking index (r = 0.249 (p = 0.006) and the smoking duration (in years) (r = 0.392 (p < 0.001)). HIT-6 scores were significantly correlated with the age at smoking onset (r=-0.190, = 0.023), smoking index (r = 0.519, p < 0.001), smoking duration (r = 0.611, p < 0.001), and number of cigarettes consumed per day (r = 0.392, p < 0.001).
CONCLUSION
CONCLUSIONS
Smoking is significantly correlated with the daily frequency of CH attacks, the frequency of CH bouts in the past five years, and the HIT-6 scores among our cohort.
Identifiants
pubmed: 39289616
doi: 10.1186/s12883-024-03706-z
pii: 10.1186/s12883-024-03706-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
349Informations de copyright
© 2024. The Author(s).
Références
May A, Schwedt TJ, Magis D, Pozo-Rosich P, Evers S, Wang SJ. Cluster headache. Nat Rev Dis Primers. 2018;4. https://doi.org/10.1038/NRDP.2018.6 .
3.1 Cluster headache - ICHD-3. Accessed April 19. 2024. https://ichd-3.org/3-trigeminal-autonomic-cephalalgias/3-1-cluster-headache/ .
3.1.1 Episodic cluster headache - ICHD-3. Accessed January 7. 2023. https://ichd-3.org/3-trigeminal-autonomic-cephalalgias/3-1-cluster-headache/3-1-1-episodic-cluster-headache/ .
3.1.2 Chronic cluster headache - ICHD-3. Accessed January 7. 2023. https://ichd-3.org/3-trigeminal-autonomic-cephalalgias/3-1-cluster-headache/3-1-2-chronic-cluster-headache/ .
Wei DYT, Yuan Ong JJ, Goadsby PJ. Cluster headache: epidemiology, pathophysiology, clinical features, and diagnosis. Ann Indian Acad Neurol. 2018;21(Suppl 1):S3. https://doi.org/10.4103/AIAN.AIAN_349_17 .
doi: 10.4103/AIAN.AIAN_349_17
pubmed: 29720812
pmcid: 5909131
Kim SA, Choi SY, Youn MS, Pozo-Rosich P, Lee MJ. Epidemiology, burden and clinical spectrum of cluster headache: a global update. https://doi.org/101177/03331024231201577 2023;43(9). https://doi.org/10.1177/03331024231201577 .
Petersen AS, Lund N, Snoer A, Jensen RH, Barloese M. The economic and personal burden of cluster headache: a controlled cross-sectional study. J Headache Pain. 2022;23(1):1–11. https://doi.org/10.1186/S10194-022-01427-7/FIGURES/3 .
doi: 10.1186/S10194-022-01427-7/FIGURES/3
Lund N, Petersen A, Snoer A, Jensen RH, Barloese M. Cluster headache is associated with unhealthy lifestyle and lifestyle-related comorbid diseases: results from the Danish cluster Headache Survey. Cephalalgia. 2019;39(2):254–63. https://doi.org/10.1177/0333102418784751 .
doi: 10.1177/0333102418784751
pubmed: 29933701
Schürks M, Diener HC. Cluster headache and lifestyle habits. Curr Pain Headache Rep. 2008;12(2):115–21. https://doi.org/10.1007/S11916-008-0022-5 .
doi: 10.1007/S11916-008-0022-5
pubmed: 18474191
Rozen TD. Cluster headache as the result of secondhand cigarette smoke exposure during childhood. Headache. 2010;50(1):130–2. https://doi.org/10.1111/J.1526-4610.2009.01542.X .
doi: 10.1111/J.1526-4610.2009.01542.X
pubmed: 19804394
Lund NLT, Snoer AH, Jensen RH. The influence of lifestyle and gender on cluster headache. Curr Opin Neurol. 2019;32(3):443–8. https://doi.org/10.1097/WCO.0000000000000680 .
doi: 10.1097/WCO.0000000000000680
pubmed: 30844861
Al-Hashel J, Ibrahim I, Youssry D, Ahmed SF, Goadsby P. Cluster headache in Kuwait: a hospital-based study. Front Neurol. 2019;10(JUN):573. https://doi.org/10.3389/FNEUR.2019.00573/BIBTEX .
doi: 10.3389/FNEUR.2019.00573/BIBTEX
pubmed: 31214109
pmcid: 6558162
Chung PW, Kim BS, Park JW, et al. Smoking history and clinical features of Cluster Headache: results from the Korean cluster Headache Registry. J Clin Neurol. 2021;17(2):229. https://doi.org/10.3988/JCN.2021.17.2.229 .
doi: 10.3988/JCN.2021.17.2.229
pubmed: 33835743
pmcid: 8053542
Rozen TD. Linking cigarette Smoking/Tobacco exposure and cluster headache: a Pathogenesis Theory. Headache. 2018;58(7):1096–112. https://doi.org/10.1111/HEAD.13338 .
doi: 10.1111/HEAD.13338
pubmed: 30011061
Winsvold BS, Harder AVE, Ran C, et al. Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and implicates smoking as causal risk factor. Ann Neurol. 2023;94(4):713–26. https://doi.org/10.1002/ANA.26743 .
doi: 10.1002/ANA.26743
pubmed: 37486023
pmcid: 10952302
Chung PW, Kim BS, Park JW, et al. Smoking history and clinical features of Cluster Headache: results from the Korean cluster Headache Registry. J Clin Neurol. 2021;17(2):229–35. https://doi.org/10.3988/JCN.2021.17.2.229 .
doi: 10.3988/JCN.2021.17.2.229
pubmed: 33835743
pmcid: 8053542
Rozen TD. Cluster headache clinical phenotypes: Tobacco Nonexposed (never smoker and no parental secondary smoke exposure as a child) versus Tobacco-Exposed: results from the United States Cluster Headache Survey. Headache. 2018;58(5):688–99. https://doi.org/10.1111/HEAD.13295 .
doi: 10.1111/HEAD.13295
pubmed: 29536529
Nachit-Ouinekh F, Dartigues JF, Henry P, et al. Use of the headache impact test (HIT-6) in general practice: relationship with quality of life and severity. Eur J Neurol. 2005;12(3):189–93. https://doi.org/10.1111/J.1468-1331.2004.00934.X .
doi: 10.1111/J.1468-1331.2004.00934.X
pubmed: 15693807
Kosinski M, Bayliss MS, Bjorner JB, et al. A six-item short-form survey for measuring headache impact: the HIT-6. Qual Life Res. 2003;12(8):963–74. https://doi.org/10.1023/A:1026119331193 .
doi: 10.1023/A:1026119331193
pubmed: 14651415
ICH GCP. ICH GCP (Good Clinical Practice) Training Course. Published 2011. Accessed April 4. 2020. https://ichgcp.net/ .
HHS. Federalwide Assurance (FWA) for the Protection of Human Subjects | HHS.gov. Accessed August 6. 2021. https://www.hhs.gov/ohrp/register-irbs-and-obtain-fwas/fwas/fwa-protection-of-human-subjecct/index.html .
Rozen TD. Cluster headache as the result of secondhand cigarette smoke exposure during Childhood. Headache: J Head Face Pain. 2010;50(1):130–2. https://doi.org/10.1111/J.1526-4610.2009.01542.X .
doi: 10.1111/J.1526-4610.2009.01542.X
Govare A, Leroux E. Licit and illicit drug use in cluster headache. Curr Pain Headache Rep. 2014;18(5):1–8. https://doi.org/10.1007/S11916-014-0413-8/TABLES/1 .
doi: 10.1007/S11916-014-0413-8/TABLES/1
Tiraferri I, Righi F, Zappaterra M et al. Can cigarette smoking worsen the clinical course of cluster headache? The Journal of Headache and Pain 2013 14:1. 2013;14(1):1–1. https://doi.org/10.1186/1129-2377-14-S1-P54 .
Hannerz J. Symptoms and diseases and smoking habits in female episodic cluster headache and migraine patients. Cephalalgia. 1997;17(4):499–500. https://doi.org/10.1046/J.1468-2982.1997.1704499.X .
doi: 10.1046/J.1468-2982.1997.1704499.X
pubmed: 9209769
Levi R, Edman GV, Ekbom K, Waldenlind E. Episodic cluster headache II: high Tobacco and Alcohol Consumption in Males1. Headache: J Head Face Pain. 1992;32(4):184–7. https://doi.org/10.1111/J.1526-4610.1992.HED3204184.X .
doi: 10.1111/J.1526-4610.1992.HED3204184.X
Lin KH, Wang PJ, Fuh JL, et al. Cluster headache in the Taiwanese - A clinic-based study. Cephalalgia. 2004;24(8):631–8. https://doi.org/10.1111/J.1468-2982.2003.00721.X/ASSET/IMAGES/LARGE/10.1111_J.1468-2982.2003.00721.X-FIG3.JPEG .
doi: 10.1111/J.1468-2982.2003.00721.X/ASSET/IMAGES/LARGE/10.1111_J.1468-2982.2003.00721.X-FIG3.JPEG
pubmed: 15265051
Al-Hashel J, Ibrahim I, Youssry D, Ahmed SF, Goadsby P. Cluster headache in Kuwait: a hospital-based study. Front Neurol. 2019;10(JUN):462955. https://doi.org/10.3389/FNEUR.2019.00573/BIBTEX .
doi: 10.3389/FNEUR.2019.00573/BIBTEX
Yalinay Dikmen P, Ari C, Sahin E, et al. Cluster analysis revealed two hidden phenotypes of Cluster Headache. Front Neurol. 2022;13:898022. https://doi.org/10.3389/FNEUR.2022.898022/BIBTEX .
doi: 10.3389/FNEUR.2022.898022/BIBTEX
pubmed: 35669872
pmcid: 9163308
Sjöstrand C, Russell MB, Ekbom K, Waldenlind E. Familial cluster headache: demographic patterns in affected and nonaffected. Headache: J Head Face Pain. 2010;50(3):374–82. https://doi.org/10.1111/J.1526-4610.2009.01426.X .
doi: 10.1111/J.1526-4610.2009.01426.X
Rozen TD, Fishman RS. Female cluster headache in the United States of America: what are the gender differences? Results from the United States Cluster Headache Survey. J Neurol Sci. 2012;317(1–2):17–28. https://doi.org/10.1016/J.JNS.2012.03.006 .
doi: 10.1016/J.JNS.2012.03.006
pubmed: 22482825
Fouda S, Kelany M, Moustafa N, et al. Tobacco smoking in Egypt: a scoping literature review of its epidemiology and control measures. East Mediterr Health J. 2018;24(2):198–215. https://doi.org/10.26719/2018.24.2.198 .
doi: 10.26719/2018.24.2.198
pubmed: 29748949
Lund N, Petersen A, Snoer A, Jensen RH, Barloese M. Cluster headache is associated with unhealthy lifestyle and lifestyle-related comorbid diseases: results from the Danish cluster Headache Survey. Cephalalgia. 2019;39(2):254–63. https://doi.org/10.1177/0333102418784751/ASSET/IMAGES/LARGE/10.1177_0333102418784751-FIG1.JPEG .
doi: 10.1177/0333102418784751/ASSET/IMAGES/LARGE/10.1177_0333102418784751-FIG1.JPEG
pubmed: 29933701