Synbiotics in patients at risk for spontaneous preterm birth: protocol for a multi-centre, double-blind, randomised placebo-controlled trial (PRIORI).

Humans Female Double-Blind Method Pregnancy Premature Birth / prevention & control Synbiotics / administration & dosage Multicenter Studies as Topic Randomized Controlled Trials as Topic Vagina / microbiology Risk Factors Microbiota Gestational Age Infant, Newborn Treatment Outcome Vaginosis, Bacterial / microbiology
Lactobacilli Next-generation sequencing PPROM Pregnancy Prematurity Preterm birth Probiotics Randomised controlled trial Synbiotics Vaginal microbiome

Journal

Trials
ISSN: 1745-6215
Titre abrégé: Trials
Pays: England
ID NLM: 101263253

Informations de publication

Date de publication:
17 Sep 2024
Historique:
received: 29 04 2024
accepted: 02 09 2024
medline: 18 9 2024
pubmed: 18 9 2024
entrez: 17 9 2024
Statut: epublish

Résumé

Prematurity remains one of the main causes of neonatal morbidity and mortality. Approximately two thirds of preterm births are spontaneous, i.e. secondary to preterm labour, preterm prelabour rupture of membranes (PPROM) or cervical insufficiency. Etiologically, the vaginal microbiome plays an important role in spontaneous preterm birth (sPTB). Vaginal dysbiosis and bacterial vaginosis are well-known risk factors for ascending lower genital tract infections and sPTB, while a Lactobacillus crispatus-dominated vaginal microbiome is associated with term deliveries. Synbiotics may help to achieve and/or maintain a normal, Lactobacillus-dominated vaginal microbiome. We will perform a multi-centre, double-blind, randomised, placebo-controlled trial. Women aged 18 years or older with a singleton pregnancy are eligible for inclusion at 8 This study will evaluate the effect of oral synbiotics on the vaginal microbiome during pregnancy in a high-risk population and correlate the microbial changes with the gestational age at delivery and relevant pregnancy outcomes. ClinicalTrials.gov, NCT05966649. Registered on April 5, 2024.

Sections du résumé

BACKGROUND BACKGROUND
Prematurity remains one of the main causes of neonatal morbidity and mortality. Approximately two thirds of preterm births are spontaneous, i.e. secondary to preterm labour, preterm prelabour rupture of membranes (PPROM) or cervical insufficiency. Etiologically, the vaginal microbiome plays an important role in spontaneous preterm birth (sPTB). Vaginal dysbiosis and bacterial vaginosis are well-known risk factors for ascending lower genital tract infections and sPTB, while a Lactobacillus crispatus-dominated vaginal microbiome is associated with term deliveries. Synbiotics may help to achieve and/or maintain a normal, Lactobacillus-dominated vaginal microbiome.
METHODS METHODS
We will perform a multi-centre, double-blind, randomised, placebo-controlled trial. Women aged 18 years or older with a singleton pregnancy are eligible for inclusion at 8
DISCUSSION CONCLUSIONS
This study will evaluate the effect of oral synbiotics on the vaginal microbiome during pregnancy in a high-risk population and correlate the microbial changes with the gestational age at delivery and relevant pregnancy outcomes.
TRIAL REGISTRATION BACKGROUND
ClinicalTrials.gov, NCT05966649. Registered on April 5, 2024.

Identifiants

DOI: 10.1186/s13063-024-08444-8 PMID: 39289685
pubmed: 39289685
doi: 10.1186/s13063-024-08444-8
pii: 10.1186/s13063-024-08444-8
doi:

Banques de données

ClinicalTrials.gov
['NCT05966649']

Types de publication

Journal Article Clinical Trial Protocol

Langues

eng

Sous-ensembles de citation

IM

Pagination

615

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Katrien Nulens (K)

Department of Obstetrics and Gynaecology, Ziekenhuis Oost-Limburg, Genk, Belgium. katrien_nulens@hotmail.com.
Department of Development and Regeneration, KULeuven, Cluster Woman and Child, Leuven, Belgium. katrien_nulens@hotmail.com.
ORCID: 0000-0002-6718-1454

Els Papy (E)

Department of Obstetrics and Gynaecology, Ziekenhuis Oost-Limburg, Genk, Belgium.

Katrien Tartaglia (K)

Clinical Trial Unit, Ziekenhuis Oost-Limburg, Genk, Belgium.

Isabelle Dehaene (I)

Department of Obstetrics and Gynaecology, Ghent University Hospital, Ghent, Belgium.

Hilde Logghe (H)

Department of Obstetrics and Gynaecology, AZ Sint-Lucas, Bruges, Belgium.
Department of Obstetrics and Gynaecology, AZ Sint-Jan, Bruges, Belgium.

Joachim Van Keirsbilck (J)

Department of Obstetrics and Gynaecology, AZ Sint-Jan, Bruges, Belgium.

Frédéric Chantraine (F)

Department of Obstetrics and Gynaecology, Hopital Citadelle, CHU Liège, Liège, Belgium.

Veronique Masson (V)

Department of Obstetrics and Gynaecology, Hopital Citadelle, CHU Liège, Liège, Belgium.

Eva Simoens (E)

Department of Obstetrics and Gynaecology, AZ Groeninge, Kortrijk, Belgium.

Willem Gysemans (W)

Department of Paediatrics and Neonatal Intensive Care Unit, Ziekenhuis Oost-Limburg, Genk, Belgium.

Liesbeth Bruckers (L)

Data Science Institute, I-Biostat, Hasselt University, Diepenbeek, Belgium.

Sarah Lebeer (S)

Department of Bioscience Engineering, Research Group Applied Microbiology and Biotechnology, University of Antwerp, Antwerp, Belgium.

Camille Nina Allonsius (CN)

Department of Bioscience Engineering, Research Group Applied Microbiology and Biotechnology, University of Antwerp, Antwerp, Belgium.

Eline Oerlemans (E)

Department of Bioscience Engineering, Research Group Applied Microbiology and Biotechnology, University of Antwerp, Antwerp, Belgium.

Deborah Steensels (D)

Department of Microbiology, Ziekenhuis Oost-Limburg, Genk, Belgium.
Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium.

Marijke Reynders (M)

Department of Microbiology, AZ Sint-Jan, Bruges, Belgium.

Dirk Timmerman (D)

Department of Development and Regeneration, KULeuven, Cluster Woman and Child, Leuven, Belgium.
Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.

Roland Devlieger (R)

Department of Development and Regeneration, KULeuven, Cluster Woman and Child, Leuven, Belgium.
Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.

Caroline Van Holsbeke (C)

Department of Obstetrics and Gynaecology, Ziekenhuis Oost-Limburg, Genk, Belgium.
Department of Obstetrics and Gynaecology, AZ Sint-Lucas, Bruges, Belgium.
Department of Obstetrics and Gynaecology, AZ Sint-Jan, Bruges, Belgium.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Méthode en double aveugle › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Complications du travail obstétrical › Travail obstétrical prématuré › Naissance prématurée › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Probiotiques › Synbiotiques › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études multicentriques comme sujet › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Appareil urogénital › Système génital › Système génital de la femme › Vagin › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Âge gestationnel › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Synbiotics in patients at risk for spontaneous...
questionsmedicales.fr › Maladies urogénitales › Maladies génitales › Maladies de l'appareil génital féminin › Maladies du vagin › Vaginite › Vaginose bactérienne › Synbiotics in patients at risk for spontaneous...