Development of specific anti-mouse atypical chemokine receptor 4 monoclonal antibodies.

Leukocyte migration is an essential function of innate and adaptive immune responses. Chemokines and their receptors control the migration system. The abundance of chemokines is controlled by atypical chemokine receptors (ACKRs), chemokine receptor-like molecules that do not couple to the G protein signaling pathways. Among them, ACKR4 regulates dendritic cell migration by controlling the ligands and is involved in tumor development in mouse models. Because no anti-mouse ACKR4 (mACKR4) monoclonal antibody (mAb) for flow cytometry has been reported, this study aimed to develop a novel mAb for mACKR4. Among the established anti-mACKR4 mAbs, A

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Déclaration de conflit d'intérêts

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yukinari Kato reports financial support was provided by 10.13039/100009619Japan Agency for Medical Research and Development. Hiroyuki Suzuki reports financial support was provided by 10.13039/501100001691Japan Society for the Promotion of Science. Mika K. Kaneko reports financial support was provided by 10.13039/501100001691Japan Society for the Promotion of Science. Tomohiro Tanaka reports financial support was provided by 10.13039/501100001691Japan Society for the Promotion of Science. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.