Increased expression of psoriasin (S100A7) and interleukin 17 (IL-17) in lesional skin in lichen planopilaris.

Lichen planopilaris (LPP) is an inflammatory, primary scarring alopecia, however its pathogenesis is not completely elucidated. S100A7 is a multifunctional, antimicrobial protein with proinflammatory properties. Interleukin-17 (IL-17) is implicated in the development of various autoimmune skin diseases. To determine the tissue expression of S100A7, S100A4 and IL-17 in LPP. The immunohistochemical analysis was performed on biopsy specimens obtained from individuals with histologically confirmed lichen planopilaris ( The number of cells showing S100A7 expression was significantly higher in LPP lesional skin compared to AA lesional skin ( The results of our study suggest the possible role of S100A7 and IL-17 in the pathogenesis of LPP.

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