Benign-by-Design SAHA Analogues for Human and Animal Vector-Borne Parasitic Diseases.

Journal

ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073

Informations de publication

Date de publication:
12 Sep 2024
Historique:
received: 28 05 2024
revised: 24 07 2024
accepted: 08 08 2024
pmc-release: 12 09 2025
medline: 18 9 2024
pubmed: 18 9 2024
entrez: 18 9 2024
Statut: epublish

Résumé

The search for new drugs fulfilling One Health and Green Chemistry requirements is an urgent call. Here, for the first time, we envisaged developing SAHA analogues by starting from the cashew nutshell liquid (CNSL) agro-industrial waste and employing a metathesis approach. This sustainable combination (comprising principles #7 and #9) allowed a straightforward synthesis of compounds

Identifiants

DOI: 10.1021/acsmedchemlett.4c00242 PMID: 39291036 PMC: PMC11403742
pubmed: 39291036
doi: 10.1021/acsmedchemlett.4c00242
pmc: PMC11403742
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1506-1515

Informations de copyright

© 2024 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

Auteurs

Michele Rossi (M)

Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, Bologna 40126, Italy.

Bianca Martinengo (B)

Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, Bologna 40126, Italy.
ORCID: 0000-0002-4239-8120

Eleonora Diamanti (E)

Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, Bologna 40126, Italy.

Alessandra Salerno (A)

Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, Bologna 40126, Italy.

Nicola Rizzardi (N)

Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, Bologna 40126, Italy.

Romana Fato (R)

Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, Bologna 40126, Italy.

Christian Bergamini (C)

Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, Bologna 40126, Italy.

Andressa Souza de Oliveira (A)

Laboratório de Desenvolvimento de Inovações Terapêuticas, Núcleo de Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasília 70910-900, Brazil.

Thais de Araújo Marques Ferreira (T)

Laboratório de Desenvolvimento de Inovações Terapêuticas, Núcleo de Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasília 70910-900, Brazil.

Cleonice Andrade Holanda (C)

Laboratório de Desenvolvimento de Inovações Terapêuticas, Núcleo de Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasília 70910-900, Brazil.

Luiz Antonio Soares Romeiro (LAS)

Laboratório de Desenvolvimento de Inovações Terapêuticas, Núcleo de Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasília 70910-900, Brazil.
ORCID: 0000-0001-5679-0820

Maria de Nazaré Correia Soeiro (MNC)

Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fiocruz. Avenida Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040360, Brazil.

Krislayne Nunes (K)

Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fiocruz. Avenida Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040360, Brazil.

Ludmila Ferreira de Almeida Fiuza (L)

Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fiocruz. Avenida Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040360, Brazil.

Marcos Meuser Batista (M)

Laboratório de Biologia Celular do Instituto Oswaldo Cruz, Fiocruz. Avenida Brasil 4365, Manguinhos, Rio de Janeiro CEP 21040360, Brazil.

Carlos A M Fraga (CAM)

Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
ORCID: 0000-0001-6733-7079

Hamed E A Alkhalaf (H)

School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G43 2DX, United Kingdom.

Ehab Kotb Elmahallawy (EK)

Departamento de Sanidad Animal, Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), Facultad de Veterinaria, Universidad de Córdoba, Córdoba 14014, Spain.
Department of Zoonoses, Faculty of Veterinary Medicine, Sohag University, Sohag 82524, Egypt.

Godwin U Ebiloma (GU)

School of Science, Engineering & Environment, University of Salford, Manchester M5 4NT, United Kingdom.

Harry P De Koning (HP)

School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G43 2DX, United Kingdom.
ORCID: 0000-0002-9963-1827

Serena Vittorio (S)

Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, Milan 20133, Italy.

Giulio Vistoli (G)

Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, Milan 20133, Italy.
ORCID: 0000-0002-3939-5172

Christophe Blanquart (C)

Nantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, Nantes CRCI2NA, France.

Philippe Bertrand (P)

University of Poitiers IC2MP UMR CNRS 7285, 4, rue Michel Brunet - TSA 51106. B27, Poitiers cedex 9 86073, France.
ORCID: 0000-0001-8171-2031

Maria Laura Bolognesi (ML)

Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, Bologna 40126, Italy.
ORCID: 0000-0002-1289-5361

Classifications MeSH