Genome scan reveals several loci associated with torus palatinus.
GWAS
exonic variants
exostosis
torus palatinus
Journal
Orthodontics & craniofacial research
ISSN: 1601-6343
Titre abrégé: Orthod Craniofac Res
Pays: England
ID NLM: 101144387
Informations de publication
Date de publication:
18 Sep 2024
18 Sep 2024
Historique:
revised:
29
08
2024
received:
27
06
2024
accepted:
05
09
2024
medline:
18
9
2024
pubmed:
18
9
2024
entrez:
18
9
2024
Statut:
aheadofprint
Résumé
Torus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest a hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study is to identify genetic variants associated with TP. We assessed the TP status of 829 individuals from various ancestral backgrounds using 3D palate scans. We then carried out a genome-wide association study (GWAS) to identify common variants associated with TP. We also performed gene-based tests across the exome to investigate the role of low-frequency coding variants. Our GWAS did not identify any genome-wide significant signals but identified suggestive associations including hits on chromosomes 2, 5 and 17 with p-values less than 5 × 10 These findings suggest that multiple genes likely influence the development of TP. Independent replication will be required to confirm our suggestive associations.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDCR NIH HHS
ID : R01-DE016148
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01-DE032122
Pays : United States
Organisme : NIDCR NIH HHS
ID : X01-HG011437
Pays : United States
Organisme : NIDCR NIH HHS
ID : R00-DE024571
Pays : United States
Organisme : NIDCR NIH HHS
ID : S21-MD001830
Pays : United States
Organisme : NIDCR NIH HHS
ID : U54-GM133807
Pays : United States
Informations de copyright
© 2024 The Author(s). Orthodontics & Craniofacial Research published by John Wiley & Sons Ltd.
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