The Role and Research Progress of Mitochondria in Sensorineural Hearing Loss.
Hair cell
Inner ear
Mitochondrial
Mitophagy
Oxidative stress
mtDNA
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
18 Sep 2024
18 Sep 2024
Historique:
received:
26
02
2024
accepted:
30
08
2024
medline:
18
9
2024
pubmed:
18
9
2024
entrez:
18
9
2024
Statut:
aheadofprint
Résumé
Hearing loss is one of the most common human diseases, seriously affecting everyday lives. Mitochondria, as the energy metabolism center in cells, are also involved in regulating active oxygen metabolism and mediating the occurrence of inflammation and apoptosis. Mitochondrial defects are closely related to hearing diseases. Studies have shown that mitochondrial DNA mutations are one of the causes of hereditary hearing loss. In addition, changes in mitochondrial homeostasis are directly related to noise-induced hearing loss and presbycusis. This review mainly summarizes and discusses the effects of mitochondrial dysfunction and mitophagy on hearing loss. Subsequently, we introduce the recent research progress of targeted mitochondria therapy in the hearing system.
Identifiants
pubmed: 39292339
doi: 10.1007/s12035-024-04470-4
pii: 10.1007/s12035-024-04470-4
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Coffin AB, Rubel EW, Raible DW (2013) Bax, Bcl2, and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line. J Assoc Res Otolaryngol: JARO 14:645–659. https://doi.org/10.1007/s10162-013-0404-1
doi: 10.1007/s10162-013-0404-1
pubmed: 23821348
pmcid: 3767879
Tan WJT, Song L (2023) Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss. Hear Res 434:108783. https://doi.org/10.1016/j.heares.2023.108783
doi: 10.1016/j.heares.2023.108783
pubmed: 37167889
Hutchin TP, Cortopassi GA (2000) Mitochondrial defects and hearing loss. Cell Mol Life Sci: CMLS 57:1927–1937. https://doi.org/10.1007/pl00000673
doi: 10.1007/pl00000673
pubmed: 11215518
pmcid: 11146800
Zheng J, Ji Y, Guan MX (2012) Mitochondrial tRNA mutations associated with deafness. Mitochondrion 12:406–413. https://doi.org/10.1016/j.mito.2012.04.001
doi: 10.1016/j.mito.2012.04.001
pubmed: 22538251
Fu X et al (2021) Mechanism and prevention of ototoxicity induced by aminoglycosides. Front Cell Neurosci 15:692762. https://doi.org/10.3389/fncel.2021.692762
doi: 10.3389/fncel.2021.692762
pubmed: 34211374
pmcid: 8239227
Johnson KR, Zheng QY, Bykhovskaya Y, Spirina O, Fischel-Ghodsian N (2001) A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice. Nat Genet 27:191–194. https://doi.org/10.1038/84831
doi: 10.1038/84831
pubmed: 11175788
pmcid: 2862214
Tan WJT et al (2017) Novel role of the mitochondrial protein Fus1 in protection from premature hearing loss via regulation of oxidative stress and nutrient and energy sensing pathways in the inner ear. Antioxid Redox Signal 27:489–509. https://doi.org/10.1089/ars.2016.6851
doi: 10.1089/ars.2016.6851
pubmed: 28135838
pmcid: 5564041
Niu X, Trifunovic A, Larsson NG, Canlon B (2007) Somatic mtDNA mutations cause progressive hearing loss in the mouse. Exp Cell Res 313:3924–3934. https://doi.org/10.1016/j.yexcr.2007.05.029
doi: 10.1016/j.yexcr.2007.05.029
pubmed: 17662273
Xie C et al (2022) Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow. Nat Biomed Eng 6:76–93. https://doi.org/10.1038/s41551-021-00819-5
doi: 10.1038/s41551-021-00819-5
pubmed: 34992270
pmcid: 8782726
Li P et al (2023) Mitochondrial dysfunction in hearing loss: oxidative stress, autophagy and NLRP3 inflammasome. Front Cell Dev Biol 11:1119773. https://doi.org/10.3389/fcell.2023.1119773
doi: 10.3389/fcell.2023.1119773
pubmed: 36891515
pmcid: 9986271
Yu X et al (2021) The expression of PHB2 in the cochlea: possible relation to age-related hearing loss. Cell Biol Int 45:2490–2498. https://doi.org/10.1002/cbin.11693
doi: 10.1002/cbin.11693
pubmed: 34435719
Anderson S et al (1981) Sequence and organization of the human mitochondrial genome. Nature 290:457–465. https://doi.org/10.1038/290457a0
doi: 10.1038/290457a0
pubmed: 7219534
Kauppila TES, Kauppila JHK, Larsson NG (2017) Mammalian mitochondria and aging: an update. Cell Metab 25:57–71. https://doi.org/10.1016/j.cmet.2016.09.017
doi: 10.1016/j.cmet.2016.09.017
pubmed: 28094012
Markaryan A, Nelson EG, Hinojosa R (2009) Quantification of the mitochondrial DNA common deletion in presbycusis. Laryngoscope 119:1184–1189. https://doi.org/10.1002/lary.20218
doi: 10.1002/lary.20218
pubmed: 19358252
Mkaouar-Rebai E et al (2010) Whole mitochondrial genome screening in two families with hearing loss: detection of a novel mutation in the 12S rRNA gene. Biosci Rep 30:405–411. https://doi.org/10.1042/bsr20090120
doi: 10.1042/bsr20090120
pubmed: 20055758
Muyderman H et al (2012) The mitochondrial T1095C mutation increases gentamicin-mediated apoptosis. Mitochondrion 12:465–471. https://doi.org/10.1016/j.mito.2012.06.006
doi: 10.1016/j.mito.2012.06.006
pubmed: 22735573
Ibrahim I, Dominguez-Valentin M, Segal B, Zeitouni A, da Silva SD (2018) Mitochondrial mutations associated with hearing and balance disorders. Mutat Res 810:39–44. https://doi.org/10.1016/j.mrfmmm.2018.03.003
doi: 10.1016/j.mrfmmm.2018.03.003
pubmed: 29615272
Kokotas H et al (2011) Detection of deafness-causing mutations in the Greek mitochondrial genome. Dis Markers 30:283–289. https://doi.org/10.3233/dma-2011-0786
doi: 10.3233/dma-2011-0786
pubmed: 21725156
pmcid: 3825241
Li X et al (2004) Biochemical characterization of the mitochondrial tRNASer(UCN) T7511C mutation associated with nonsyndromic deafness. Nucleic Acids Res 32:867–877. https://doi.org/10.1093/nar/gkh226
doi: 10.1093/nar/gkh226
pubmed: 14960712
pmcid: 373379
Maassen JA et al (2004) Mitochondrial diabetes: molecular mechanisms and clinical presentation. Diabetes 53(Suppl 1):S103-109. https://doi.org/10.2337/diabetes.53.2007.s103
doi: 10.2337/diabetes.53.2007.s103
pubmed: 14749274
Chomyn A, Enriquez JA, Micol V, Fernandez-Silva P, Attardi G (2000) The mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode syndrome-associated human mitochondrial tRNALeu(UUR) mutation causes aminoacylation deficiency and concomitant reduced association of mRNA with ribosomes. J Biol Chem 275:19198–19209. https://doi.org/10.1074/jbc.M908734199
doi: 10.1074/jbc.M908734199
pubmed: 10858457
Li R, Guan MX (2010) Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes. Mol Cell Biol 30:2147–2154. https://doi.org/10.1128/mcb.01614-09
doi: 10.1128/mcb.01614-09
pubmed: 20194621
pmcid: 2863588
Levinger L, Giegé R, Florentz C (2003) Pathology-related substitutions in human mitochondrial tRNA(Ile) reduce precursor 3′ end processing efficiency in vitro. Nucleic Acids Res 31:1904–1912. https://doi.org/10.1093/nar/gkg282
doi: 10.1093/nar/gkg282
pubmed: 12655007
pmcid: 152798
Gutiérrez Cortés N et al (2012) Novel mitochondrial DNA mutations responsible for maternally inherited nonsyndromic hearing loss. Hum Mutat 33:681–689. https://doi.org/10.1002/humu.22023
doi: 10.1002/humu.22023
pubmed: 22241583
Yan X et al (2011) Maternally transmitted late-onset non-syndromic deafness is associated with the novel heteroplasmic T12201C mutation in the mitochondrial tRNAHis gene. J Med Genet 48:682–690. https://doi.org/10.1136/jmedgenet-2011-100219
doi: 10.1136/jmedgenet-2011-100219
pubmed: 21931169
Ding Y, Leng J, Fan F, Xia B, Xu P (2013) The role of mitochondrial DNA mutations in hearing loss. Biochem Genet 51:588–602. https://doi.org/10.1007/s10528-013-9589-6
doi: 10.1007/s10528-013-9589-6
pubmed: 23605717
Lévêque M et al (2007) Whole mitochondrial genome screening in maternally inherited non-syndromic hearing impairment using a microarray resequencing mitochondrial DNA chip. Eur J Hum Genet: EJHG 15:1145–1155. https://doi.org/10.1038/sj.ejhg.5201891
doi: 10.1038/sj.ejhg.5201891
pubmed: 17637808
Jornayvaz FR, Shulman GI (2010) Regulation of mitochondrial biogenesis. Essays Biochem 47:69–84. https://doi.org/10.1042/bse0470069
doi: 10.1042/bse0470069
pubmed: 20533901
Itoh K, Nakamura K, Iijima M, Sesaki H (2013) Mitochondrial dynamics in neurodegeneration. Trends Cell Biol 23:64–71. https://doi.org/10.1016/j.tcb.2012.10.006
doi: 10.1016/j.tcb.2012.10.006
pubmed: 23159640
Fujimoto C, Yamasoba T (2014) Oxidative stresses and mitochondrial dysfunction in age-related hearing loss. Oxid Med Cell Longev 2014:582849. https://doi.org/10.1155/2014/582849
doi: 10.1155/2014/582849
pubmed: 25110550
pmcid: 4106174
Zhong Y et al (2012) Age-related decline of the cytochrome c oxidase subunit expression in the auditory cortex of the mimetic aging rat model associated with the common deletion. Hear Res 294:40–48. https://doi.org/10.1016/j.heares.2012.09.006
doi: 10.1016/j.heares.2012.09.006
pubmed: 23022596
Zhao XY et al (2013) The effect of overexpression of PGC-1α on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model. Hear Res 296:13–24. https://doi.org/10.1016/j.heares.2012.11.007
doi: 10.1016/j.heares.2012.11.007
pubmed: 23159434
Su Z et al (2019) LncRNA AW112010 promotes mitochondrial biogenesis and hair cell survival: implications for age-related hearing loss. Oxid Med Cell Longev 2019:6150148. https://doi.org/10.1155/2019/6150148
doi: 10.1155/2019/6150148
pubmed: 31781342
pmcid: 6855056
He Z et al (2016) Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro. Sci Rep 6:29621. https://doi.org/10.1038/srep29621
doi: 10.1038/srep29621
pubmed: 27405449
pmcid: 4942793
Gong S et al (2020) Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNA(His) mutation. J Biol Chem 295:940–954. https://doi.org/10.1074/jbc.RA119.010998
doi: 10.1074/jbc.RA119.010998
pubmed: 31819004
Agnew T et al (2018) A Wars2 mutant mouse model displays OXPHOS deficiencies and activation of tissue-specific stress response pathways. Cell Rep 25:3315-3328.e3316. https://doi.org/10.1016/j.celrep.2018.11.080
doi: 10.1016/j.celrep.2018.11.080
pubmed: 30566859
pmcid: 6315286
Gardeitchik T et al (2018) Bi-allelic mutations in the mitochondrial ribosomal protein MRPS2 cause sensorineural hearing loss, hypoglycemia, and multiple OXPHOS complex deficiencies. Am J Hum Genet 102:685–695. https://doi.org/10.1016/j.ajhg.2018.02.012
doi: 10.1016/j.ajhg.2018.02.012
pubmed: 29576219
pmcid: 5985281
Di Fonzo A et al (2009) The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency. Am J Hum Genet 84:594–604. https://doi.org/10.1016/j.ajhg.2009.04.004
doi: 10.1016/j.ajhg.2009.04.004
pubmed: 19409522
pmcid: 2681006
Bahmad F Jr, Merchant SN, Nadol JB Jr, Tranebjaerg L (2007) Otopathology in Mohr-Tranebjaerg syndrome. Laryngoscope 117:1202–1208. https://doi.org/10.1097/MLG.0b013e3180581944
doi: 10.1097/MLG.0b013e3180581944
pubmed: 17471106
pmcid: 2515094
Wang X et al (2018) Mitochondrial calcium transporters mediate sensitivity to noise-induced losses of hair cells and cochlear synapses. Front Mol Neurosci 11:469. https://doi.org/10.3389/fnmol.2018.00469
doi: 10.3389/fnmol.2018.00469
pubmed: 30670946
Wu F et al (2022) Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ. Cell Mol Life Sci: CMLS 79:249. https://doi.org/10.1007/s00018-022-04268-4
doi: 10.1007/s00018-022-04268-4
pubmed: 35438341
pmcid: 9844253
Fujinami Y et al (2010) Enhanced expression of C/EBP homologous protein (CHOP) precedes degeneration of fibrocytes in the lateral wall after acute cochlear mitochondrial dysfunction induced by 3-nitropropionic acid. Neurochem Int 56:487–494. https://doi.org/10.1016/j.neuint.2009.12.008
doi: 10.1016/j.neuint.2009.12.008
pubmed: 20026213
Fujioka M et al (2014) Pharmacological inhibition of cochlear mitochondrial respiratory chain induces secondary inflammation in the lateral wall: a potential therapeutic target for sensorineural hearing loss. PLoS One 9:e90089. https://doi.org/10.1371/journal.pone.0090089
doi: 10.1371/journal.pone.0090089
pubmed: 24614528
pmcid: 3948682
Chen B et al (2020) Mechanisms of hearing loss and cell death in the cochlea of connexin mutant mice. Am J Physiol Cell Physiol 319:C569-c578. https://doi.org/10.1152/ajpcell.00483.2019
doi: 10.1152/ajpcell.00483.2019
pubmed: 32755449
Huebner AK et al (2019) Early hearing loss upon disruption of Slc4a10 in C57BL/6 mice. J Assoc Res Otolaryngol: JARO 20:233–245. https://doi.org/10.1007/s10162-019-00719-1
doi: 10.1007/s10162-019-00719-1
pubmed: 31001720
pmcid: 6514043
Miwa T, Wei FY, Tomizawa K (2021) Cdk5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss. Mol Brain 14:82. https://doi.org/10.1186/s13041-021-00791-w
doi: 10.1186/s13041-021-00791-w
pubmed: 34001214
pmcid: 8130336
Lee YY et al (2020) Type 1 diabetes induces hearing loss: functional and histological findings in an Akita mouse model. Biomedicines 8(9):343. https://doi.org/10.3390/biomedicines8090343
doi: 10.3390/biomedicines8090343
pubmed: 32932780
pmcid: 7555388
Milkovic L, CipakGasparovic A, Cindric M, Mouthuy PA, Zarkovic N (2019) Short overview of ROS as cell function regulators and their implications in therapy concepts. Cells 8(8):793. https://doi.org/10.3390/cells8080793
doi: 10.3390/cells8080793
pubmed: 31366062
pmcid: 6721558
He ZH et al (2021) FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway. Autophagy 17:4341–4362. https://doi.org/10.1080/15548627.2021.1916194
doi: 10.1080/15548627.2021.1916194
pubmed: 34006186
pmcid: 8726647
Alvarado JC et al (2015) Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss. Front Aging Neurosci 7:86. https://doi.org/10.3389/fnagi.2015.00086
doi: 10.3389/fnagi.2015.00086
pubmed: 26029103
pmcid: 4432684
Menardo J et al (2012) Oxidative stress, inflammation, and autophagic stress as the key mechanisms of premature age-related hearing loss in SAMP8 mouse Cochlea. Antioxid Redox Signal 16:263–274. https://doi.org/10.1089/ars.2011.4037
doi: 10.1089/ars.2011.4037
pubmed: 21923553
McFadden SL, Ding D, Reaume AG, Flood DG, Salvi RJ (1999) Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase. Neurobiol Aging 20:1–8. https://doi.org/10.1016/s0197-4580(99)00018-4
doi: 10.1016/s0197-4580(99)00018-4
pubmed: 10466888
Someya S et al (2009) Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci USA 106:19432–19437. https://doi.org/10.1073/pnas.0908786106
doi: 10.1073/pnas.0908786106
pubmed: 19901338
pmcid: 2780799
Bermúdez-Muñoz JM et al (2020) G6PD overexpression protects from oxidative stress and age-related hearing loss. Aging Cell 19:e13275. https://doi.org/10.1111/acel.13275
doi: 10.1111/acel.13275
pubmed: 33222382
pmcid: 7744953
Lautermann J, Crann SA, McLaren J, Schacht J (1997) Glutathione-dependent antioxidant systems in the mammalian inner ear: effects of aging, ototoxic drugs and noise. Hear Res 114:75–82. https://doi.org/10.1016/s0378-5955(97)00154-8
doi: 10.1016/s0378-5955(97)00154-8
pubmed: 9447921
Van Eyken E et al (2007) Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment. J Med Genet 44:570–578. https://doi.org/10.1136/jmg.2007.049205
doi: 10.1136/jmg.2007.049205
pubmed: 17513527
pmcid: 2597944
White K et al (2018) Loss of IDH2 accelerates age-related hearing loss in male mice. Sci Rep 8:5039. https://doi.org/10.1038/s41598-018-23436-w
doi: 10.1038/s41598-018-23436-w
pubmed: 29567975
pmcid: 5864918
Kim YR et al (2019) Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency. Redox Biol 20:544–555. https://doi.org/10.1016/j.redox.2018.11.013
doi: 10.1016/j.redox.2018.11.013
pubmed: 30508699
Sugiura S, Uchida Y, Nakashima T, Ando F, Shimokata H (2010) The association between gene polymorphisms in uncoupling proteins and hearing impairment in Japanese elderly. Acta Otolaryngol 130:487–492. https://doi.org/10.3109/00016480903283758
doi: 10.3109/00016480903283758
pubmed: 19895332
Kwon DN, Park WJ, Choi YJ, Gurunathan S, Kim JH (2015) Oxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing loss. Aging (Albany NY) 7:579–594. https://doi.org/10.18632/aging.100800
doi: 10.18632/aging.100800
pubmed: 26319214
Shih CP et al (2021) Inhibition of cochlear HMGB1 expression attenuates oxidative stress and inflammation in an experimental murine model of noise-induced hearing loss. Cells 10(4):810. https://doi.org/10.3390/cells10040810
doi: 10.3390/cells10040810
pubmed: 33916471
pmcid: 8066810
Sergi B, Ferraresi A, Troiani D, Paludetti G, Fetoni AR (2003) Cisplatin ototoxicity in the guinea pig: vestibular and cochlear damage. Hear Res 182:56–64. https://doi.org/10.1016/s0378-5955(03)00142-4
doi: 10.1016/s0378-5955(03)00142-4
pubmed: 12948602
He Y et al (2020) Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death. Theranostics 10:133–150. https://doi.org/10.7150/thno.37362
doi: 10.7150/thno.37362
pubmed: 31903111
pmcid: 6929624
Chen H, Tang J (2014) The role of mitochondria in age-related hearing loss. Biogerontology 15:13–19. https://doi.org/10.1007/s10522-013-9475-y
doi: 10.1007/s10522-013-9475-y
pubmed: 24202185
Hobbie SN et al (2008) Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity. Proc Natl Acad Sci USA 105:20888–20893. https://doi.org/10.1073/pnas.0811258106
doi: 10.1073/pnas.0811258106
pubmed: 19104050
pmcid: 2634874
Pickett SB et al (2018) Cumulative mitochondrial activity correlates with ototoxin susceptibility in zebrafish mechanosensory hair cells. Elife 7:e38062. https://doi.org/10.7554/eLife.38062
doi: 10.7554/eLife.38062
pubmed: 30596476
pmcid: 6345563
Wu J, Ye J, Kong W, Zhang S, Zheng Y (2020) Programmed cell death pathways in hearing loss: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 53:e12915. https://doi.org/10.1111/cpr.12915
doi: 10.1111/cpr.12915
pubmed: 33047870
pmcid: 7653260
Sha SH, Chen FQ, Schacht J (2009) Activation of cell death pathways in the inner ear of the aging CBA/J mouse. Hear Res 254:92–99. https://doi.org/10.1016/j.heares.2009.04.019
doi: 10.1016/j.heares.2009.04.019
pubmed: 19422898
pmcid: 2749985
Vicente-Torres MA, Schacht J (2006) A BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss. J Neurosci Res 83:1564–1572. https://doi.org/10.1002/jnr.20832
doi: 10.1002/jnr.20832
pubmed: 16521126
pmcid: 1525045
Youle RJ, Narendra DP (2011) Mechanisms of mitophagy. Nat Rev Mol Cell Biol 12:9–14. https://doi.org/10.1038/nrm3028
doi: 10.1038/nrm3028
pubmed: 21179058
pmcid: 4780047
Dombi E, Mortiboys H, Poulton J (2018) Modulating mitophagy in mitochondrial disease. Curr Med Chem 25:5597–5612. https://doi.org/10.2174/0929867324666170616101741
doi: 10.2174/0929867324666170616101741
pubmed: 28618992
Oh J, Youn CK, Jun Y, Jo ER, Cho SI (2020) Reduced mitophagy in the cochlea of aged C57BL/6J mice. Exp Gerontol 137:110946. https://doi.org/10.1016/j.exger.2020.110946
doi: 10.1016/j.exger.2020.110946
pubmed: 32387126
Youn CK, Jun Y, Jo ER, Cho SI (2020) Age-related hearing loss in C57BL/6J mice is associated with mitophagy impairment in the central auditory system. Int J Mol Sci 21(19):7202. https://doi.org/10.3390/ijms21197202
doi: 10.3390/ijms21197202
pubmed: 33003463
pmcid: 7584026
Xiong H et al (2019) Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis. Neurobiol Aging 79:30–42. https://doi.org/10.1016/j.neurobiolaging.2019.03.013
doi: 10.1016/j.neurobiolaging.2019.03.013
pubmed: 31026620
Lin H et al (2019) Inhibition of DRP-1-dependent mitophagy promotes cochlea hair cell senescence and exacerbates age-related hearing loss. Front Cell Neurosci 13:550. https://doi.org/10.3389/fncel.2019.00550
doi: 10.3389/fncel.2019.00550
pubmed: 31920551
pmcid: 6929675
Kros CJ, Steyger PS (2019) Aminoglycoside- and cisplatin-induced ototoxicity: mechanisms and otoprotective strategies. Cold Spring Harbor Perspect Med 9(11):a033548. https://doi.org/10.1101/cshperspect.a033548
doi: 10.1101/cshperspect.a033548
Wang X et al (2023) Cisplatin-induced ototoxicity: from signaling network to therapeutic targets. Biomed Pharmacother 157:114045. https://doi.org/10.1016/j.biopha.2022.114045
doi: 10.1016/j.biopha.2022.114045
pubmed: 36455457
He Y et al (2022) Inhibiting DNA methylation alleviates cisplatin-induced hearing loss by decreasing oxidative stress-induced mitochondria-dependent apoptosis via the LRP1-PI3K/AKT pathway. Acta pharmaceutica Sinica B 12:1305–1321. https://doi.org/10.1016/j.apsb.2021.11.002
doi: 10.1016/j.apsb.2021.11.002
pubmed: 35530135
Dehne N, Lautermann J, Petrat F, Rauen U, de Groot H (2001) Cisplatin ototoxicity: involvement of iron and enhanced formation of superoxide anion radicals. Toxicol Appl Pharmacol 174:27–34. https://doi.org/10.1006/taap.2001.9171
doi: 10.1006/taap.2001.9171
pubmed: 11437646
Qiao X et al (2024) Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress. Int J Biol Sci 20:784–800. https://doi.org/10.7150/ijbs.82003
doi: 10.7150/ijbs.82003
pubmed: 38169643
pmcid: 10758089
Liu W et al (2021) PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage. Autophagy 17:4159–4181. https://doi.org/10.1080/15548627.2021.1905466
doi: 10.1080/15548627.2021.1905466
pubmed: 33749526
pmcid: 8726717
Dirain CO, Ng M, Milne-Davies B, Joseph JK, Antonelli PJ (2018) Evaluation of mitoquinone for protecting against amikacin-induced ototoxicity in guinea pigs. Otol Neurotol 39:111–118. https://doi.org/10.1097/mao.0000000000001638
doi: 10.1097/mao.0000000000001638
pubmed: 29194212
pmcid: 5728173
Li J, Liu C, Müller U, Zhao B (2023) Autophagy proteins are essential for aminoglycoside-induced hearing loss. Autophagy 19:1599–1600. https://doi.org/10.1080/15548627.2022.2127525
doi: 10.1080/15548627.2022.2127525
pubmed: 36184596
Zhang Y et al (2023) Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage. Autophagy 19:75–91. https://doi.org/10.1080/15548627.2022.2062872
doi: 10.1080/15548627.2022.2062872
pubmed: 35471096
Jankauskas SS et al (2012) Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss. Biochemistry Biokhimiia 77:666–670. https://doi.org/10.1134/s0006297912060144
doi: 10.1134/s0006297912060144
pubmed: 22817467
Ding ZJ et al (2015) Calpain inhibitor PD150606 attenuates glutamate induced spiral ganglion neuron apoptosis through apoptosis inducing factor pathway in vitro. PLoS One 10:e0123130. https://doi.org/10.1371/journal.pone.0123130
doi: 10.1371/journal.pone.0123130
pubmed: 25874633
pmcid: 4398365
Li Y et al (2023) Sestrin 2 deficiency exacerbates noise-induced cochlear injury through inhibiting ULK1/Parkin-mediated mitophagy. Antioxid Redox Signal 38:115–136. https://doi.org/10.1089/ars.2021.0283
doi: 10.1089/ars.2021.0283
pubmed: 35708118
pmcid: 9885551