The impact of different reconstruction parameters on quantitative
99mTc-DPD SPECT/CT
ATTR cardiac amyloidosis
Quantification
Quantitative SPECT/CT
Reconstruction parameter
SUV
Journal
The international journal of cardiovascular imaging
ISSN: 1875-8312
Titre abrégé: Int J Cardiovasc Imaging
Pays: United States
ID NLM: 100969716
Informations de publication
Date de publication:
18 Sep 2024
18 Sep 2024
Historique:
received:
23
01
2024
accepted:
21
08
2024
medline:
18
9
2024
pubmed:
18
9
2024
entrez:
18
9
2024
Statut:
aheadofprint
Résumé
To assess in a phantom and in a clinical study the influence of different reconstruction parameters on quantitative SPECT/CT values in the assessment of cardiac transthyretin amyloidosis (ATTR-CA). A hybrid SPECT/CT camera with a proprietary software for SPECT/CT-based quantification of myocardial uptake of The standard parameters provided by the manufacturer (reconstruction 1) yielded higher accuracy in quantifying, with measuring 97.1% of the expected activity in the phantom. Reconstructions with higher Gaussian filter caused a systematic underestimation of quantified values of 27.2% (p < 0.01). Results were replicated in the clinical study consisting of 155 patients with suspected ATTR-CA, wherein changing the number of iterations and subsets was not associated with a statistically significant difference in quantitative values compared to reconstruction 1, while a higher Gaussian filter caused inaccurate quantification with up to 24% of difference measured. Different reconstruction parameters can impact quantitative values on
Identifiants
pubmed: 39292397
doi: 10.1007/s10554-024-03231-7
pii: 10.1007/s10554-024-03231-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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