Estimating the Economically Justifiable Price of Limited-Duration Treatment with Donanemab for Early Symptomatic Alzheimer's Disease in the United States.

Donanemab Alzheimer’s disease Amyloid-targeting therapies Cost-effectiveness Economically justifiable price

Journal

Neurology and therapy
ISSN: 2193-8253
Titre abrégé: Neurol Ther
Pays: New Zealand
ID NLM: 101637818

Informations de publication

Date de publication:
18 Sep 2024
Historique:
received: 28 05 2024
accepted: 19 07 2024
medline: 18 9 2024
pubmed: 18 9 2024
entrez: 18 9 2024
Statut: aheadofprint

Résumé

The goal of this economic model is to estimate an economically justifiable price (EJP) for using donanemab for the treatment of early symptomatic Alzheimer's disease (AD) in the United States based on clinical data from the phase 3 TRAILBLAZER-ALZ 2 trial (NCT04437511). We adapted an AD Markov state-transition model developed by the Institute for Clinical and Economic Review to estimate the EJP for donanemab at different willingness-to-pay (WTP) thresholds from the health care system perspective and the societal perspective as co-base cases. Assuming a WTP threshold of $150,000 per quality-adjusted life-year (QALY) gained, the model estimates a 1-year (13-dose) EJP for donanemab of $80,538 from the health care system perspective and $91,126 from the societal perspective; at a WTP threshold of $100,000 per QALY gained, the model estimates a 1-year (13-dose) EJP for donanemab of $44,691 from the health care system perspective and $55,419 from the societal perspective. Mean total treatment costs per patient at the $150,000 per QALY gained EJP derived from the health care system perspective were estimated at $77,812 based on the average number of doses of donanemab patients received in the co-base case analysis. One-way sensitivity analysis (OWSA) indicated that treatment efficacy, disease severity at the time of treatment initiation, and duration of treatment effect were the main drivers of the potential EJP. Results from this modeling simulation informed by the TRAILBLAZER-ALZ 2 study support an EJP for limited-duration treatment with donanemab that exceeds per-dose list prices for currently available amyloid-targeting therapies, implying potentially lower lifetime costs and better value for money.

Identifiants

pubmed: 39292433
doi: 10.1007/s40120-024-00649-y
pii: 10.1007/s40120-024-00649-y
doi:

Banques de données

ClinicalTrials.gov
['NCT04437511']

Types de publication

Journal Article

Langues

eng

Informations de copyright

© 2024. The Author(s).

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Auteurs

Malaz Boustani (M)

Division of Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

Erin G Doty (EG)

Lilly Corporate Center, Indianapolis, IN, 46285, USA.

Louis P Garrison (LP)

Department of Pharmacy, The CHOICE Institute, University of Washington, Seattle, WA, USA.

Lee J Smolen (LJ)

Medical Decision Modeling Inc, Indianapolis, IN, USA.

Timothy M Klein (TM)

Medical Decision Modeling Inc, Indianapolis, IN, USA.

Daniel R Murphy (DR)

Medical Decision Modeling Inc, Indianapolis, IN, USA.

Andrew W Spargo (AW)

Lilly Corporate Center, Indianapolis, IN, 46285, USA.

Mark Belger (M)

Eli Lilly and Company, Bracknell, UK.

Joseph A Johnston (JA)

Lilly Corporate Center, Indianapolis, IN, 46285, USA. johnston_joseph_a@lilly.com.

Classifications MeSH