The divisome is a self-enhancing machine in Escherichia coli and Caulobacter crescentus.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 Sep 2024
18 Sep 2024
Historique:
received:
12
03
2024
accepted:
27
08
2024
medline:
19
9
2024
pubmed:
19
9
2024
entrez:
18
9
2024
Statut:
epublish
Résumé
During bacterial cytokinesis, polymers of the bacterial tubulin FtsZ coalesce into the Z ring to orchestrate divisome assembly and septal cell wall synthesis. Previous studies have found that Z ring condensation and stability is critical for successful cell division. However, how FtsZ filaments condense into a Z ring remains enigmatic and whether septal cell wall synthesis can feedback to the Z ring has not been investigated. Here, we show that FtsZ-associated proteins (Zaps) play important roles in Z ring condensation and stability, and discover septal cell wall synthesis as a novel player for Z ring condensation and stabilization in Escherichia coli and Caulobacter crescentus. Moreover, we find that the interaction between the Z ring membrane anchor, FtsA, and components of the septal cell wall synthetic complex are critical for septal cell wall synthesis-mediated Z ring condensation. Altogether, these findings suggest that the divisome is a self-enhancing machine in these two gram-negative bacteria, where the Z ring and the septal cell wall synthetic complex communicate with and reinforce each other to ensure robustness of cell division.
Identifiants
pubmed: 39294118
doi: 10.1038/s41467-024-52217-5
pii: 10.1038/s41467-024-52217-5
doi:
Substances chimiques
Bacterial Proteins
0
FtsZ protein, Bacteria
0
Cytoskeletal Proteins
0
Escherichia coli Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8198Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32070032
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32270049
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32270035
Organisme : Natural Science Foundation of Anhui Province (Anhui Provincial Natural Science Foundation)
ID : 2208085MC40
Informations de copyright
© 2024. The Author(s).
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