Toxoplasma FER1 is a versatile and dynamic mediator of differential microneme trafficking and microneme exocytosis.
Toxoplasma
Exocytosis
Ferlin
Microneme
Trafficking
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 Sep 2024
18 Sep 2024
Historique:
received:
11
06
2024
accepted:
09
09
2024
medline:
19
9
2024
pubmed:
19
9
2024
entrez:
18
9
2024
Statut:
epublish
Résumé
Toxoplasma gondii is a polarized cell concentrating several secretory organelles at the apical pole. The secretory micronemes come in two sub-populations differentiated by dependence on Rab5A/C in their biogenesis. Calcium-dependent exocytosis of micronemes occurs at the very apical tip and is critical for parasite egress from its host cell, adhesion and invasion of the next cell. Ferlins represent a protein family with roles in exocytosis containing multiple Ca
Identifiants
pubmed: 39294204
doi: 10.1038/s41598-024-72628-0
pii: 10.1038/s41598-024-72628-0
doi:
Substances chimiques
Protozoan Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21819Subventions
Organisme : NIH HHS
ID : AI060767
Pays : United States
Organisme : NIH HHS
ID : AI108251
Pays : United States
Organisme : NIH HHS
ID : AI122042
Pays : United States
Organisme : American Cancer Society
ID : RSG-12-175-01-MPC
Organisme : National Science Foundation
ID : 1626072
Informations de copyright
© 2024. The Author(s).
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