Why do we study sphingolipids?

Ceramide Evolution Metabolic pathways Sphingolipids Sphingosine 1-phosphate

Journal

Pflugers Archiv : European journal of physiology

ISSN: 1432-2013

Titre abrégé: Pflugers Arch

Pays: Germany

ID NLM: 0154720

Informations de publication

Date de publication:
19 Sep 2024

Historique:

received: 22 08 2024

accepted: 10 09 2024

revised: 22 08 2024

medline: 19 9 2024

pubmed: 19 9 2024

entrez: 18 9 2024

Statut: aheadofprint

Résumé

Research on sphingolipids has proliferated exponentially over the past couple of decades, as exemplified in the findings reported at the International Leopoldina Symposium on Lipid Signaling held in Frankfurt in late 2023. Most researchers in the field study how sphingolipids function in regulating a variety of cellular processes and, in particular, how they are dysregulated in numerous human diseases; however, I now propose that we implement a more holistic research program in our study of sphingolipids, which embraces a sense of awe and wonder at the complexities and beauty of sphingolipids and of sphingolipid metabolism. I will outline the chemical complexity of sphingolipids, their modes of interaction within the lipid bilayer, and their biosynthetic pathways. I will then briefly touch upon the ability of current neo-Darwinian mechanisms to explain the emergence of both sphingolipids and of the complex pathways that generate them. Although such discussion is normally considered taboo in biological circles, I nevertheless submit that in-depth analysis of the minutiae of metabolic pathways, such as those of the sphingolipid biosynthetic pathway, raises challenges to current neo-Darwinian mechanisms that should not be shunned or ignored.

Identifiants

DOI: 10.1007/s00424-024-03020-0 PMID: 39294442

pubmed: 39294442

doi: 10.1007/s00424-024-03020-0

pii: 10.1007/s00424-024-03020-0

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Informations de copyright

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