Incidental finding of intramural splenic heterotopy in the colon mimicking subepithelial neoplasm: a case report.
Colonoscopies
Congenital defects
EUS-FNA
Splenosis
Journal
Journal of medical case reports
ISSN: 1752-1947
Titre abrégé: J Med Case Rep
Pays: England
ID NLM: 101293382
Informations de publication
Date de publication:
19 Sep 2024
19 Sep 2024
Historique:
received:
10
11
2023
accepted:
21
08
2024
medline:
19
9
2024
pubmed:
19
9
2024
entrez:
18
9
2024
Statut:
epublish
Résumé
The aim of this case report is describe an unprecedented case with histological and immunohistochemical diagnosis of splenic heterotopy in the colon using material obtained by endoscopic ultrasound-guided biopsy. Splenic heterotopia is a benign condition characterized by the implantation of splenic tissue in areas distant from its usual anatomical site, such as the peritoneum, omentum, mesentery, liver, pancreas, and subcutaneous tissue and, more rarely, in locations such as the colon and brain. It is generally associated with a history of splenic trauma or splenectomy and typically does not cause specific symptoms. A 35-year-old white male patient who was healthy, with no history of trauma or splenectomy, but had a family history of colorectal neoplasia underwent colonoscopy for screening. The examination revealed a large bulge in the proximal descending colon, covered by normal-appearing mucosa. Endoscopic ultrasound-guided puncture was performed with a 22 gauge fine needle biopsy, and the histopathological and immunohistochemical analysis results were consistent with a heterotopic spleen. This is the first report of a primary intramural colic splenosis case with histological and immunohistochemical diagnosis of splenic heterotopia in the colon, using material obtained by endoscopic ultrasound and ultrasound-guided biopsy.
Sections du résumé
AIM
OBJECTIVE
The aim of this case report is describe an unprecedented case with histological and immunohistochemical diagnosis of splenic heterotopy in the colon using material obtained by endoscopic ultrasound-guided biopsy.
BACKGROUND
BACKGROUND
Splenic heterotopia is a benign condition characterized by the implantation of splenic tissue in areas distant from its usual anatomical site, such as the peritoneum, omentum, mesentery, liver, pancreas, and subcutaneous tissue and, more rarely, in locations such as the colon and brain. It is generally associated with a history of splenic trauma or splenectomy and typically does not cause specific symptoms.
CASE PRESENTATION
METHODS
A 35-year-old white male patient who was healthy, with no history of trauma or splenectomy, but had a family history of colorectal neoplasia underwent colonoscopy for screening. The examination revealed a large bulge in the proximal descending colon, covered by normal-appearing mucosa. Endoscopic ultrasound-guided puncture was performed with a 22 gauge fine needle biopsy, and the histopathological and immunohistochemical analysis results were consistent with a heterotopic spleen.
CONCLUSIONS
CONCLUSIONS
This is the first report of a primary intramural colic splenosis case with histological and immunohistochemical diagnosis of splenic heterotopia in the colon, using material obtained by endoscopic ultrasound and ultrasound-guided biopsy.
Identifiants
pubmed: 39294715
doi: 10.1186/s13256-024-04766-y
pii: 10.1186/s13256-024-04766-y
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
437Informations de copyright
© 2024. The Author(s).
Références
Vergara D, Ginolfi F, Moscati S, Giordano B, Ferrara N, Panico C, et al. Multiple intra-hepatic and abdominal splenosis: an easy call if you know about it. Acta Radiol Open. 2018;7(5):2058460118772324.
pubmed: 29780616
pmcid: 5952290
Kravarusic D, Feigin E, Freud E. Unique case of intramural colonic splenosis. J Pediatr Surg. 2006;41(5):e15–7.
doi: 10.1016/j.jpedsurg.2005.12.057
pubmed: 16677869
Mackie WJ, Miller DF. Splenosis. A case report and some considerations on the function of splenotic tissue. Br J Surg. 1973;60(1):56–8.
doi: 10.1002/bjs.1800600115
pubmed: 4685922
Fleming CR, Dickson ER, Harrison EG Jr. Splenosis: autotransplantation of splenic tissue. Am J Med. 1976;61(3):414–9.
doi: 10.1016/0002-9343(76)90380-6
pubmed: 961705
Cohen EA. Splenosis; review and report of subcutaneous splenic implant. AMA Arch Surg. 1954;69(6):777–84.
doi: 10.1001/archsurg.1954.01270060019004
pubmed: 13206574
Mccann WJ. Splenosis: rupture of spleen, with splenic implants; review of literature and report of case. Br Med J. 1956;1(4978):1271–2.
doi: 10.1136/bmj.1.4978.1271
pubmed: 13316128
pmcid: 1979695
Widmann WD, Laubscher FA. Splenosis. A disease or a beneficial condition? Arch Surg. 1971;102(2):152–8.
doi: 10.1001/archsurg.1971.01350020062018
pubmed: 5101334
Basile RM, Morales JM, Zupanec R. Splenosis. A cause of massive gastrointestinal hemorrhage. Arch Surg. 1989;124(9):1087–9.
doi: 10.1001/archsurg.1989.01410090097022
pubmed: 2789029
Grantham JR, Clore FC. Subcutaneous splenosis. AJR Am J Roentgenol. 1990;154(3):655.
doi: 10.2214/ajr.154.3.2106240
pubmed: 2106240
Akay S, Ilica AT, Battal B, Karaman B, Guvenc I. Pararectal mass: an atypical location of splenosis. J Clin Ultrasound. 2012;40(7):443–7.
doi: 10.1002/jcu.20843
pubmed: 21626516
Le Bars F, Pascot R, Ricordel C, Corbineau H, Verhoye JP, De Latour BR, et al. Thoracic splenosis: case report of a symptomatic case. Chin J Traumatol. 2020;23(3):185–6.
doi: 10.1016/j.cjtee.2020.05.003
pubmed: 32532660
pmcid: 7296354
Reinglas J, Perdrizet K, Ryan SE, Patel RV. Splenosis involving the gastric fundus, a rare cause of massive upper gastrointestinal bleeding: a case report and review of the literature. Clin Exp Gastroenterol. 2016;22(9):301–5.
doi: 10.2147/CEG.S91835
Schilling K. Über einen Fall von multiplen Nebenmilzen. Virchows Arch. 1907;188(1):65–87.
doi: 10.1007/BF01946085
Sirinek KR, Livingston CD, Bova JG, Levine BA. Bowel obstruction due to infarcted splenosis. South Med J. 1984;77(6):764–7.
doi: 10.1097/00007611-198406000-00026
pubmed: 6729556
Obokhare ID, Beckman E, Beck DE, Whitlow CB, Margolin DA. Intramural colonic splenosis: a rare case of lower gastrointestinal bleeding. J Gastrointest Surg. 2012;16(8):1632–4.
doi: 10.1007/s11605-012-1875-9
pubmed: 22450955
Liu Y, Ji B, Wang G, Wang Y. Abdominal multiple splenosis mimicking liver and colon tumors: a case report and review of the literature. Int J Med Sci. 2012;9(2):174–7.
doi: 10.7150/ijms.3983
pubmed: 22359484
pmcid: 3283864
Braga J, Pereira F, Fernandes C, Silva M, Boncoraglio T, Oliveira C. Abdominal splenosis mimicking a colon tumour. Eur J Case Rep Intern Med. 2021;8(1):002219.
pubmed: 33585344
pmcid: 7875586
Tang X, Gu P, Lu W. A rare case of adult colocolic intussusception secondary to splenosis. J Int Med Res. 2022;50(8):3000605221115386.
doi: 10.1177/03000605221115386
pubmed: 36036154
Trimble C, Eason FJ. A complication of splenosis. J Trauma. 1972;12(4):358–61.
doi: 10.1097/00005373-197204000-00014
pubmed: 5018416
Alvarez R, Diehl KM, Avram A, Brown R, Piert M. Localization of splenosis using 99mTc-damaged red blood cell SPECT/CT and intraoperative gamma probe measurements. Eur J Nucl Med Mol Imaging. 2007;34(6):969.
doi: 10.1007/s00259-007-0432-3
pubmed: 17457584
Franceschetto A, Casolo A, Cucca M, Bagni B. Splenosis: 99mTc-labelled colloids provide the diagnosis in splenectomised patients. Eur J Nucl Med Mol Imaging. 2006;33(9):1102.
doi: 10.1007/s00259-006-0102-x
pubmed: 16763821