Clinical analysis of influenza in the neonatal intensive care unit.
Influenza
Neonatal
Virus
Journal
Italian journal of pediatrics
ISSN: 1824-7288
Titre abrégé: Ital J Pediatr
Pays: England
ID NLM: 101510759
Informations de publication
Date de publication:
18 Sep 2024
18 Sep 2024
Historique:
received:
21
02
2024
accepted:
31
08
2024
medline:
19
9
2024
pubmed:
19
9
2024
entrez:
18
9
2024
Statut:
epublish
Résumé
The aim was to investigate the clinical characteristics, treatment and prognosis of neonatal influenza. The clinical data of 21 neonates who were diagnosed with influenza and admitted to the neonatal intensive care unit of Henan Provincial Children's Hospital, China, between January 2023 and January 2024 were retrospectively analyzed. A total of 21 patients were admitted, including 14 with influenza A and 7 with influenza B. Eighteen of these patients were reported to have been exposed to family members with respiratory symptoms before hospitalization. Among all the patients' mothers, only 1 received the influenza vaccine during pregnancy. Fifteen newborns had fever, 13 appetite loss, 10 cough, 9 shortness of breath, 9 nasal obstruction, 3 runny nose, 3 vomiting, 2 severe wheezing, 2 choking, 2 diarrhea, 1 bloating, and 1 sputum in the throat. The pulmonary auscultation sounds were coarse in 19 neonates, weak in 2, moist rales were appreciated in 5 and wheezing in 4 of them. The peripheral total white blood cell count was normal in 18 patients and elevated in 3. The C-reactive protein level was normal in all subjects, and the procalcitonin level was elevated in 1. Nineteen patients had pneumonia on chest imaging. All patients were treated with oseltamivir and finally recovered. Influenza A is the most common type of neonatal influenza. The clinical symptoms are atypical, and fever is the main symptom. Treatment with oseltamivir is safe and effective, and the prognosis is mostly favorable.
Sections du résumé
BACKGROUND
BACKGROUND
The aim was to investigate the clinical characteristics, treatment and prognosis of neonatal influenza.
METHODS
METHODS
The clinical data of 21 neonates who were diagnosed with influenza and admitted to the neonatal intensive care unit of Henan Provincial Children's Hospital, China, between January 2023 and January 2024 were retrospectively analyzed.
RESULTS
RESULTS
A total of 21 patients were admitted, including 14 with influenza A and 7 with influenza B. Eighteen of these patients were reported to have been exposed to family members with respiratory symptoms before hospitalization. Among all the patients' mothers, only 1 received the influenza vaccine during pregnancy. Fifteen newborns had fever, 13 appetite loss, 10 cough, 9 shortness of breath, 9 nasal obstruction, 3 runny nose, 3 vomiting, 2 severe wheezing, 2 choking, 2 diarrhea, 1 bloating, and 1 sputum in the throat. The pulmonary auscultation sounds were coarse in 19 neonates, weak in 2, moist rales were appreciated in 5 and wheezing in 4 of them. The peripheral total white blood cell count was normal in 18 patients and elevated in 3. The C-reactive protein level was normal in all subjects, and the procalcitonin level was elevated in 1. Nineteen patients had pneumonia on chest imaging. All patients were treated with oseltamivir and finally recovered.
CONCLUSION
CONCLUSIONS
Influenza A is the most common type of neonatal influenza. The clinical symptoms are atypical, and fever is the main symptom. Treatment with oseltamivir is safe and effective, and the prognosis is mostly favorable.
Identifiants
pubmed: 39294774
doi: 10.1186/s13052-024-01742-6
pii: 10.1186/s13052-024-01742-6
doi:
Substances chimiques
Antiviral Agents
0
Oseltamivir
20O93L6F9H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
184Subventions
Organisme : 2023 Open Subjects of Henan Provincial Engineering Research Center for Diagnosis and Treatment of Pediatric Infections and Critical Illnesses
ID : ERC202304
Organisme : Medical Science and Technology Project of Zhejiang Province
ID : LHGJ20220734
Organisme : Jiangsu Provincial Agricultural Science and Technology Independent Innovation Fund
ID : LHGJ20230600
Informations de copyright
© 2024. The Author(s).
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